Search Results - "Testa, JE"

Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy by Schnitzer, Jan E, Oh, Phil, Li, Yan, Yu, Jingyi, Durr, Eberhard, Krasinska, Karolina M, Carver, Lucy A, Testa, Jacqueline E

“…The molecular complexity of tissues and the inaccessibility of most cells within a tissue limit the discovery of key targets for tissue-specific delivery of…”
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Direct proteomic mapping of the lung microvascular endothelial cell surface in vivo and in cell culture by Schnitzer, Jan E, Durr, Eberhard, Yu, Jingyi, Krasinska, Karolina M, Carver, Lucy A, Yates, John R, Testa, Jacqueline E, Oh, Phil

“…Endothelial cells can function differently in vitro and in vivo; however, the degree of microenvironmental modulation in vivo remains unknown at the molecular…”
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Screening Phage Display Libraries for Organ-Specific Vascular Immunotargeting in vivo by Valadon, Philippe, Garnett, Jeff D., Testa, Jacqueline E., Bauerle, Marc, Oh, Phil, Schnitzer, Jan E.

“…The molecular diversity of the luminal endothelial cell surface arising in vivo from local variations in genetic expression and tissue microenvironment may…”
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Subtractive immunization using highly metastatic human tumor cells identifies SIMA135 CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen by HOOPER, John D, ZIJLSTRA, Andries, AIMES, Ronald T, HONGYAN LIANG, CLAASSEN, Gisela F, TARIN, David, TESTA, Jacqueline E, QUIGLEY, James P

“…We have previously used a subtractive immunization (SI) approach to generate monoclonal antibodies (mAbs) against proteins preferentially expressed by the…”
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Eukaryotic expression cloning with an antimetastatic monoclonal antibody identifies a tetraspanin (PETA-3/CD151) as an effector of human tumor cell migration and metastasis by TESTA, J. E, BROOKS, P. C, LIN, J.-M, QUIGLEY, J. P

“…A monoclonal antibody (mAb), 50-6, generated by subtractive immunization, was found to specifically inhibit in vivo metastasis of a human epidermoid carcinoma…”
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Targeting the proteome/epitome, implementation of subtractive immunization by Zijlstra, Andries, Testa, Jacqueline E, Quigley, James P

“…Monoclonal antibody technology has generated invaluable tools for both the analytical and clinical sciences. However, standard immunization approaches…”
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Borrelia burgdorferi binds plasminogen, resulting in enhanced penetration of endothelial monolayers by COLEMAN, J. L, SELLATI, T. J, TESTA, J. E, KEW, R. R, FURIE, M. B, BENACH, J. L

“…Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
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The role of urokinase-type plasminogen activator in aggressive tumor cell behavior by TESTA, J. E, QUIGLEY, J. P

“…The correlation between urokinase-type plasminogen activator (uPA) expression and tumor cell invasion and metastasis has been well documented. Urokinase…”
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Loss of the metastatic phenotype by a human epidermoid carcinoma cell line, HEp-3, is accompanied by increased expression of tissue inhibitor of metalloproteinase 2 by TESTA, J. E

“…The human epidermoid carcinoma cell line HEp-3 gives rise to spontaneous metastases in nude mice and in the chick chorioallantoic membrane (CAM) assay system…”
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Introduction of an RRHR Motif into Chicken Urokinase-Type Plasminogen Activator (Ch-uPA) Confers Sensitivity to Plasminogen Activator Inhibitor (PAI)-1 and PAI-2 and Allows ch-uPA-Mediated Extracellular Matrix Degradation to be controlled PAI-1 by Sipley, John D., Alexander, Daniela S., Testa, Jacqueline E., Quigley, James P.

“…Comparison of the amino acid sequence of the chicken and human workinase-type plasminogen activators (uPAs) revealed that the putative PAI-binding site found…”
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Co-inoculation of human and murine carcinoma cells induces reciprocal suppression of metastasis by both cell lines by Nielsen-Preiss, S M, Quigley, J P, Testa, J E

“…The interactions of two cell lines having different metastatic properties, and the subsequent effects on dissemination were investigated using the chicken…”
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Reversal of misfortune: TIMP-2 inhibits tumor cell invasion by Testa, J E, Quigley, J P

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Protease receptors on cell surfaces: new mechanistic formulas applied to an old problem by Testa, J E, Quigley, J P

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Urokinase-type plasminogen activator biosynthesis is induced by the EJ-Ha-ras oncogene in CL26 mouse colon carcinoma cells by Testa, J E, Medcalf, R L, Cajot, J F, Schleuning, W D, Sordat, B

“…CL26 murine colon carcinoma cells express urokinase-type plasminogen activator (u-PA) mRNA and activity after transfection with the activated c-Ha-ras-I…”
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Molecular mechanisms involved in T cell activation. III. The role of extracellular calcium in antigen-induced lymphokine production and interleukin 2-induced proliferation of cloned cytotoxic T lymphocytes by Harris, DT, Kozumbo, WJ, Testa, JE, Cerutti, PA, Cerottini, JC

“…The role that extracellular calcium plays in activating resting cloned cytotoxic T lymphocytes (CTL) to proliferate and to produce lymphokines was examined. In…”
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