Search Results - "Tessman, Robert"

Simultaneous quantification of trimethoprim metabolites in pediatric plasma by Tessman, Robert T., Nolte, Whitney, Toren, Paul, Gibson, Kim, Vu, Linda, Goldman, Jennifer

“…•Efficient workflow allows for rapid quantification of trimethoprim and metabolites.•Human plasma trimethoprim metabolic profiles.•Pediatric study. The dual…”
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Sustained O-GlcNAcylation reprograms mitochondrial function to regulate energy metabolism by Tan, Ee Phie, McGreal, Steven R., Graw, Stefan, Tessman, Robert, Koppel, Scott J., Dhakal, Pramod, Zhang, Zhen, Machacek, Miranda, Zachara, Natasha E., Koestler, Devin C., Peterson, Kenneth R., Thyfault, John P., Swerdlow, Russell H., Krishnamurthy, Partha, DiTacchio, Luciano, Apte, Udayan, Slawson, Chad

“…Dysfunctional mitochondria and generation of reactive oxygen species (ROS) promote chronic diseases, which have spurred interest in the molecular mechanisms…”
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Screening trimethoprim primary metabolites for covalent binding to albumin by Nolte, Whitney M., Tessman, Robert T., Goldman, Jennifer L.

“…Modification of endogenous proteins by drugs and drug metabolites are thought to be a cause of idiosyncratic adverse drug reactions (IADRs). Trimethoprim (TMP)…”
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Preliminary observations of mitochondrial dysfunction in Prader–Willi syndrome by Butler, Merlin G., Hossain, Waheeda A., Tessman, Robert, Krishnamurthy, Partha C.

“…Prader–Willi syndrome (PWS) is a complex multisystem disorder because of errors in genomic imprinting with severe hypotonia, decreased muscle mass, poor…”
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Hypoxic Adaptation by a Unique Mechanism of Reprogramming Mitochondrial Metabolism by Tessman, Robert T, Chavan, Hementkumar, Du, Gouqing, Sun, Daxi, Schuetz, John, Krishnamurthy, Partha

“…Abstract only Hypoxia plays critical roles in the pathobiology of heart disease, cancer, stroke, and chronic lung disease, which are responsible for 60% of…”
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Functional Coupling of ATP-binding Cassette Transporter Abcb6 to Cytochrome P450 Expression and Activity in Liver by Chavan, Hemantkumar, Li, Feng, Tessman, Robert, Mickey, Kristen, Dorko, Kenneth, Schmitt, Timothy, Kumer, Sean, Gunewardena, Sumedha, Gaikwad, Nilesh, Krishnamurthy, Partha

“…Although endogenous mechanisms that negatively regulate cytochrome P450 (P450) monooxygenases in response to physiological and pathophysiological signals are…”
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Arsenite Effects on Mitochondrial Bioenergetics in Human and Mouse Primary Hepatocytes Follow a Nonlinear Dose Response by Krishnamurthy, Partha, Ni, Hong-Min, Tessman, Robert, Mickey, Kristen, Christudoss, Pamela, Chavan, Hemantkumar, Swerdlow, Russell H.

“…Arsenite is a known carcinogen and its exposure has been implicated in a variety of noncarcinogenic health concerns. Increased oxidative stress is thought to…”
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O‐GlcNAc is Critical for the Regulation of Energy Metabolism by Tan, Ee Phie, McGreal, Steven, Graw, Stefan, Tessman, Robert, Koppel, Scott, Dhakal, Pramod, Zhang, Zhen, Machacek, Miranda, Soares, Michael J, Zachara, Natasha, Koestler, Devin, Peterson, Kenneth R, Thyfault, John P, Swerdlow, Russell H, Kasturi, Partha, Apte, Udayan, Slawson, Chad

“…Abstract only O‐linked N ‐acetylglucosamine (O‐GlcNAc) is the attachment of a single β‐N‐acetylglucosamine to serine/threonine amino acid residues of nuclear,…”
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The Role of Mitochondrial ATP-Binding Cassette Transporter ABCB6 in Metabolism and Energy Balance by Tessman, Robert T

“…Obesity and the associated health risks represent a world-wide health and financial crisis. Lack of physical activity combined with excessive caloric intake…”
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