Search Results - "Tessier, Philippe"

DAMP molecule S100A9 acts as a molecular pattern to enhance inflammation during influenza A virus infection: role of DDX21-TRIF-TLR4-MyD88 pathway by Tsai, Su-Yu, Segovia, Jesus A, Chang, Te-Hung, Morris, Ian R, Berton, Michael T, Tessier, Philippe A, Tardif, Mélanie R, Cesaro, Annabelle, Bose, Santanu

“…Pathogen-associated molecular patterns (PAMPs) trigger host immune response by activating pattern recognition receptors like toll-like receptors (TLRs)…”
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Acute inflammatory response via neutrophil activation protects against the development of chronic pain by Parisien, Marc, Lima, Lucas V, Dagostino, Concetta, El-Hachem, Nehme, Drury, Gillian L, Grant, Audrey V, Huising, Jonathan, Verma, Vivek, Meloto, Carolina B, Silva, Jaqueline R, Dutra, Gabrielle G S, Markova, Teodora, Dang, Hong, Tessier, Philippe A, Slade, Gary D, Nackley, Andrea G, Ghasemlou, Nader, Mogil, Jeffrey S, Allegri, Massimo, Diatchenko, Luda

“…The transition from acute to chronic pain is critically important but not well understood. Here, we investigated the pathophysiological mechanisms underlying…”
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S100A9: The Unusual Suspect Connecting Viral Infection and Inflammation by Boucher, Julien, Gilbert, Caroline, Bose, Santanu, Tessier, Philippe A

“…The study of S100A9 in viral infections has seen increased interest since the COVID-19 pandemic. S100A8/A9 levels were found to be correlated with the severity…”
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An inflammation loop orchestrated by S100A9 and calprotectin is critical for development of arthritis by Cesaro, Annabelle, Anceriz, Nadia, Plante, Audrey, Pagé, Nathalie, Tardif, Mélanie R, Tessier, Philippe A

“…The S100A9 and S100A8 proteins are highly expressed by neutrophils and monocytes and are part of a group of damage-associated molecular pattern molecules that…”
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S100A8 and S100A9 induce cytokine expression and regulate the NLRP3 inflammasome via ROS-dependent activation of NF-κB(1.) by Simard, Jean-Christophe, Cesaro, Annabelle, Chapeton-Montes, Julie, Tardif, Mélanie, Antoine, Francis, Girard, Denis, Tessier, Philippe A

“…S100A8 and S100A9 are cytoplasmic proteins expressed by phagocytes. High concentrations of these proteins have been correlated with various inflammatory…”
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S100A9 induces differentiation of acute myeloid leukemia cells through TLR4 by Laouedj, Malika, Tardif, Mélanie R., Gil, Laurine, Raquil, Marie-Astrid, Lachhab, Asmaa, Pelletier, Martin, Tessier, Philippe A., Barabé, Frédéric

“…S100A8 and S100A9 are calcium-binding proteins predominantly expressed by neutrophils and monocytes and play key roles in both normal and pathological…”
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The impact of the herbicide glyphosate and its metabolites AMPA and MPA on the metabolism and functions of human blood neutrophils and their sex-dependent effects on reactive oxygen species and CXCL8/IL-8 production by Leblanc, Pier-Olivier, Breton, Yann, Léveillé, Florence, Tessier, Philippe A., Pelletier, Martin

“…Significant levels of glyphosate, the world's most widely used herbicide, and its primary metabolites, AMPA and MPA, are detected in various human organs and…”
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Induction of neutrophil degranulation by S100A9 via a MAPK-dependent mechanism by Simard, Jean‐Christophe, Girard, Denis, Tessier, Philippe A.

“…S100A9 induces degranulation in human neutrophils. S100A9 is a proinflammatory protein, expressed abundantly in the cytosol of neutrophils and monocytes. High…”
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Metabolic regulation of neutrophil functions in homeostasis and diseases by Leblanc, Pier-Olivier, Bourgoin, Sylvain G, Poubelle, Patrice E, Tessier, Philippe A, Pelletier, Martin

“…Neutrophils are the most abundant leukocytes in humans and play a role in the innate immune response by being the first cells attracted to the site of…”
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Deletion of S100a8 and S100a9 Enhances Skin Hyperplasia and Promotes the Th17 Response in Imiquimod-Induced Psoriasis by Defrêne, Joan, Berrazouane, Sofiane, Esparza, Nayeli, Pagé, Nathalie, Côté, Marie-France, Gobeil, Stéphane, Aoudjit, Fawzi, Tessier, Philippe A

“…High concentrations of the damage-associated molecular patterns S100A8 and S100A9 are found in skin and serum from patients suffering from psoriasis, an…”
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IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization by Yoon, Juhan, Leyva-Castillo, Juan Manuel, Wang, Guoxing, Galand, Claire, Oyoshi, Michiko K, Kumar, Lalit, Hoff, Sabine, He, Rui, Chervonsky, Alexander, Oppenheim, Joost J, Kuchroo, Vijay K, van den Brink, Marcel R M, Malefyt, Rene De Waal, Tessier, Philippe A, Fuhlbrigge, Robert, Rosenstiel, Philip, Terhorst, Cox, Murphy, George, Geha, Raif S

“…Atopic dermatitis (AD) is a Th2-dominated inflammatory skin disease characterized by epidermal thickening. Serum levels of IL-22, a cytokine known to induce…”
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Surface RANKL of Toll-like receptor 4–stimulated human neutrophils activates osteoclastic bone resorption by Chakravarti, Arpita, Raquil, Marie-Astrid, Tessier, Philippe, Poubelle, Patrice E.

“…Inflammatory bone loss in septic and inflammatory conditions is due to increased activity of osteoclasts that requires receptor activator of NF-kappa B-ligand…”
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Enhanced myelopoiesis and aggravated arthritis in S100a8-deficient mice by Cesaro, Annabelle, Defrêne, Joan, Lachhab, Asmaa, Pagé, Nathalie, Tardif, Mélanie R, Al-Shami, Amin, Oravecz, Tamas, Fortin, Paul R, Daudelin, Jean-François, Labrecque, Nathalie, Aoudjit, Fawzi, Pelletier, Martin, Tessier, Philippe A

“…Expressed strongly by myeloid cells, damage-associated molecular pattern (DAMP) proteins S100A8 and S100A9 are found in the serum of patients with infectious…”
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Proinflammatory Activities of S100: Proteins S100A8, S100A9, and S100A8/A9 Induce Neutrophil Chemotaxis and Adhesion by Ryckman, Carle, Vandal, Karen, Rouleau, Pascal, Talbot, Marieve, Tessier, Philippe A

“…S100A8 and S100A9 are small calcium-binding proteins that are highly expressed in neutrophil and monocyte cytosol and are found at high levels in the…”
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Damage-associated molecular pattern S100A9 increases bactericidal activity of human neutrophils by enhancing phagocytosis by Simard, Jean-Christophe, Simon, Marie-Michelle, Tessier, Philippe A, Girard, Denis

“…The damage-associated molecular-pattern S100A9 is found at inflammatory sites in infections and various autoimmune diseases. It is released at very high…”
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Blockade of Antimicrobial Proteins S100A8 and S100A9 Inhibits Phagocyte Migration to the Alveoli in Streptococcal Pneumonia by Raquil, Marie-Astrid, Anceriz, Nadia, Rouleau, Pascal, Tessier, Philippe A

“…We investigated the roles of the potent, chemotactic antimicrobial proteins S100A8, S100A9, and S100A8/A9 in leukocyte migration in a model of streptococcal…”
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Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis by Fujita, Yu, Khateb, Ali, Li, Yan, Tinoco, Roberto, Zhang, Tongwu, Bar-Yoseph, Haggai, Tam, Miguel A., Chowers, Yehuda, Sabo, Edmond, Gerassy-Vainberg, Shiran, Starosvetsky, Elina, James, Brian, Brown, Kevin, Shen-Orr, Shai S., Bradley, Linda M., Tessier, Philippe A., Ronai, Ze’ev A.

“…Inflammatory bowel disease (IBD) is prevalent, but the mechanisms underlying disease development remain elusive. We identify a role for the E3 ubiquitin ligase…”
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Human S100A9 potentiates IL-8 production in response to GM-CSF or fMLP via activation of a different set of transcription factors in neutrophils by Simard, Jean-Christophe, Noël, Claudie, Tessier, Philippe A., Girard, Denis

“…•S100A9 does not increase cytokine production by itself in human neutrophils.•S100A9 primes neutrophils to GM-CSF- or fMLP-induced cytokine production.•A…”
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Expression of the myeloid inhibitory receptor CLEC12A correlates with disease activity and cytokines in early rheumatoid arthritis by Vaillancourt, Myriam, Desaulniers, Philippe, Paré, Guillaume, Pagé, Nathalie, Lachhab, Asmaa, Kerever, Anthony, Julien, Anne-Sophie, Amiable, Nathalie, Pelletier, Martin, Tessier, Philippe A., Bessette, Louis, Michou, Laëtitia, Fortin, Paul R., Fernandes, Maria J.

“…The myeloid inhibitory receptor CLEC12A negatively regulates inflammation. Reduced CLEC12A expression enhances inflammation in CLEC12A knock-out mice with…”
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Secretion of S100A8, S100A9, and S100A12 by Neutrophils Involves Reactive Oxygen Species and Potassium Efflux by Gilbert, Caroline, Pagé, Nathalie, Posvandzic, Alma, Chapeton-Montes, Julie Andrea, Tardif, Mélanie R., Tessier, Philippe A.

“…S100A8/A9 (calprotectin) and S100A12 proinflammatory mediators are found at inflammatory sites and in the serum of patients with inflammatory or autoimmune…”
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