Search Results - "Tessier, M"

Spectroscopy of Colloidal Semiconductor Core/Shell Nanoplatelets with High Quantum Yield by Tessier, M. D, Mahler, B, Nadal, B, Heuclin, H, Pedetti, S, Dubertret, B

“…Free standing two-dimensional materials appear as a novel class of structures. Recently, the first colloidal two-dimensional heterostructures have been…”
Get full text

Advances in Antibody Design by Tiller, Kathryn E, Tessier, Peter M

“…The use of monoclonal antibodies as therapeutics requires optimizing several of their key attributes. These include binding affinity and specificity, folding…”
Get full text

Colloidal nanoplatelets with two-dimensional electronic structure by Ithurria, S., Tessier, M. D., Mahler, B., Lobo, R. P. S. M., Dubertret, B., Efros, Al. L.

“…Semiconductor nanocrystals have for many years attracted attention for their optical properties and their potential use as superior fluorescence emitters. It…”
Get full text

Understanding and overcoming trade-offs between antibody affinity, specificity, stability and solubility by Rabia, Lilia A., Desai, Alec A., Jhajj, Harkamal S., Tessier, Peter M.

“…•Antibodies display trade-offs between key properties during affinity maturation.•Antibody mutations that increase affinity are commonly…”
Get full text

Erosive oral lichen planus: Think thymoma by Leroy, C., Lesclous, P., Dutot, N., Anquetil, M., Tessier, M.-H.

Get full text

The Surgical Infection Society Revised Guidelines on the Management of Intra-Abdominal Infection by Mazuski, John E, Tessier, Jeffrey M, May, Addison K, Sawyer, Robert G, Nadler, Evan P, Rosengart, Matthew R, Chang, Phillip K, O'Neill, Patrick J, Mollen, Kevin P, Huston, Jared M, Diaz, Jr, Jose J, Prince, Jose M

“…Previous evidence-based guidelines on the management of intra-abdominal infection (IAI) were published by the Surgical Infection Society (SIS) in 1992, 2002,…”
Get more information

Discovery-stage identification of drug-like antibodies using emerging experimental and computational methods by Makowski, Emily K., Wu, Lina, Gupta, Priyanka, Tessier, Peter M.

“…There is intense and widespread interest in developing monoclonal antibodies as therapeutic agents to treat diverse human disorders. During early-stage…”
Get full text

Co-optimization of therapeutic antibody affinity and specificity using machine learning models that generalize to novel mutational space by Makowski, Emily K., Kinnunen, Patrick C., Huang, Jie, Wu, Lina, Smith, Matthew D., Wang, Tiexin, Desai, Alec A., Streu, Craig N., Zhang, Yulei, Zupancic, Jennifer M., Schardt, John S., Linderman, Jennifer J., Tessier, Peter M.

“…Therapeutic antibody development requires selection and engineering of molecules with high affinity and other drug-like biophysical properties. Co-optimization…”
Get full text

Toward Drug-Like Multispecific Antibodies by Design by Sawant, Manali S, Streu, Craig N, Wu, Lina, Tessier, Peter M

“…The success of antibody therapeutics is strongly influenced by their multifunctional nature that couples antigen recognition mediated by their variable regions…”
Get full text

Efficient affinity maturation of antibody variable domains requires co-selection of compensatory mutations to maintain thermodynamic stability by Julian, Mark C., Li, Lijuan, Garde, Shekhar, Wilen, Rebecca, Tessier, Peter M.

“…The ability of antibodies to accumulate affinity-enhancing mutations in their complementarity-determining regions (CDRs) without compromising thermodynamic…”
Get full text

Emerging antiviral therapeutics for human adenovirus infection: Recent developments and novel strategies by Dodge, Mackenzie J., MacNeil, Katelyn M., Tessier, Tanner M., Weinberg, Jason B., Mymryk, Joe S.

“…Human adenoviruses (HAdV) are ubiquitous human pathogens that cause a significant burden of respiratory, ocular, and gastrointestinal illnesses. Although HAdV…”
Get full text

Arginine mutations in antibody complementarity-determining regions display context-dependent affinity/specificity trade-offs by Tiller, Kathryn E., Li, Lijuan, Kumar, Sandeep, Julian, Mark C., Garde, Shekhar, Tessier, Peter M.

“…Antibodies commonly accumulate charged mutations in their complementarity-determining regions (CDRs) during affinity maturation to enhance electrostatic…”
Get full text

Net charge of antibody complementarity-determining regions is a key predictor of specificity by Rabia, Lilia A, Zhang, Yulei, Ludwig, Seth D, Julian, Mark C, Tessier, Peter M

“…Specificity is one of the most important and complex properties that is central to both natural antibody function and therapeutic antibody efficacy. However,…”
Get full text

Hacking the Cell: Network Intrusion and Exploitation by Adenovirus E1A by King, Cason R, Zhang, Ali, Tessier, Tanner M, Gameiro, Steven F, Mymryk, Joe S

“…As obligate intracellular parasites, viruses are dependent on their infected hosts for survival. Consequently, viruses are under enormous selective pressure to…”
Get full text

Structure-based design of conformation- and sequence-specific antibodies against amyloid β by Perchiacca, Joseph M, Ladiwala, Ali Reza A, Bhattacharya, Moumita, Tessier, Peter M

“…Conformation-specific antibodies that recognize aggregated proteins associated with several conformational disorders (e.g., Parkinson and prion diseases) are…”
Get full text

Prion recognition elements govern nucleation, strain specificity and species barriers by Tessier, Peter M, Lindquist, Susan

“…Prions are proteins that can switch to self-perpetuating, infectious conformations. The abilities of prions to replicate, form structurally distinct strains,…”
Get full text

Assessing developability early in the discovery process for novel biologics by Fernández-Quintero, Monica L., Ljungars, Anne, Waibl, Franz, Greiff, Victor, Andersen, Jan Terje, Gjølberg, Torleif T., Jenkins, Timothy P., Voldborg, Bjørn Gunnar, Grav, Lise Marie, Kumar, Sandeep, Georges, Guy, Kettenberger, Hubert, Liedl, Klaus R., Tessier, Peter M., McCafferty, John, Laustsen, Andreas H.

“…Beyond potency, a good developability profile is a key attribute of a biological drug. Selecting and screening for such attributes early in the drug…”
Get full text

Mutational analysis of SARS-CoV-2 variants of concern reveals key tradeoffs between receptor affinity and antibody escape by Makowski, Emily K, Schardt, John S, Smith, Matthew D, Tessier, Peter M

“…SARS-CoV-2 variants with enhanced transmissibility represent a serious threat to global health. Here we report machine learning models that can predict the…”
Get full text

Mutational analysis of domain antibodies reveals aggregation hotspots within and near the complementarity determining regions by Perchiacca, Joseph M., Bhattacharya, Moumita, Tessier, Peter M.

“…High‐affinity antibodies are critical for numerous diagnostic and therapeutic applications, yet their utility is limited by their variable propensity to…”
Get full text

An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence by Lee, Chang-Han, Kang, Tae Hyun, Godon, Ophélie, Watanabe, Makiko, Delidakis, George, Gillis, Caitlin M., Sterlin, Delphine, Hardy, David, Cogné, Michel, Macdonald, Lynn E., Murphy, Andrew J., Tu, Naxin, Lee, Jiwon, McDaniel, Jonathan R., Makowski, Emily, Tessier, Peter M., Meyer, Aaron S., Bruhns, Pierre, Georgiou, George

“…The pharmacokinetic properties of antibodies are largely dictated by the pH-dependent binding of the IgG fragment crystallizable (Fc) domain to the human…”
Get full text