Search Results - "Tessier, G J"
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Derepression may masquerade as activation in ligand-gated ion channels
Published in Nature communications (05-04-2023)“…Agonists are ligands that bind to receptors and activate them. In the case of ligand-gated ion channels, such as the muscle-type nicotinic acetylcholine…”
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Ancestral acetylcholine receptor β-subunit forms homopentamers that prime before opening spontaneously
Published in eLife (04-07-2022)“…Human adult muscle-type acetylcholine receptors are heteropentameric ion channels formed from two α-subunits, and one each of the β-, δ-, and ε-subunits. To…”
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3
A single historical substitution drives an increase in acetylcholine receptor complexity
Published in Proceedings of the National Academy of Sciences - PNAS (16-02-2021)“…Human adult muscle-type acetylcholine receptors are heteropentameric ion channels formed from four different, but evolutionarily related, subunits. These…”
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Ancestral Reconstruction Approach to Acetylcholine Receptor Structure and Function
Published in Structure (London) (01-08-2017)“…Acetylcholine receptors (AChRs) are members of a superfamily of proteins called pentameric ligand-gated ion channels, which are found in almost all forms of…”
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pUdOs: Concise Plasmids for Bacterial and Mammalian Cells
Published in ACS synthetic biology (16-02-2024)“…The plasmids from the Université d’Ottawa (pUdOs) are 28 small plasmids each comprising one of four origins of replication and one of seven selection markers,…”
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Back to the future: Rational maps for exploring acetylcholine receptor space and time
Published in Biochimica et biophysica acta. Proteins and proteomics (01-11-2017)“…Global functions of nicotinic acetylcholine receptors, such as subunit cooperativity and compatibility, likely emerge from a network of amino acid residues…”
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7
Ion transport properties of fetal sheep alveolar epithelial cells in monolayer culture
Published in The American journal of physiology (01-06-1996)“…Alveolar type II cells were isolated from late-term fetal sheep to investigate ion transport across fetal distal lung epithelium. In Ussing chambers, basal…”
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Mechanisms of sodium and chloride transport across equine tracheal epithelium
Published in The American journal of physiology (01-12-1990)“…Equine tracheal epithelium, stripped of serosal muscle, mounted in Ussing chambers, and bathed in plasmalike Ringer solution generates a serosa-positive…”
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Mucosal histamine inhibits Na absorption and stimulates Cl secretion across equine tracheal epithelium
Published in The American journal of physiology (01-12-1991)“…When the equine tracheal epithelium is mounted in Ussing chambers and bathed in plasma-like Ringer solution, the tissue generates a lumen-negative…”
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10
Derepression masquerades as activation in a pentameric ligand-gated ion channel
Published in Biophysical journal (10-02-2023)Get full text
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11
Modulation of equine tracheal smooth muscle contractility by epithelial-derived and cyclooxygenase metabolites
Published in Respiration physiology (01-04-1991)“…The role of epithelium in the modulation of contractile responses to electrical field stimulation (EFS), acetylcholine (ACh), and KCl were studied in vitro in…”
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12
scbursts: An R package for analysis and sorting of single-channel bursts
Published in SoftwareX (01-07-2019)“…Analysis of single-channel activity provides unparalleled insight into ion channel structure, function, and mechanism. An essential step in the analysis…”
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