Search Results - "Tesoriere, G"
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Parthenolide and DMAPT exert cytotoxic effects on breast cancer stem-like cells by inducing oxidative stress, mitochondrial dysfunction and necrosis
Published in Cell death & disease (14-04-2016)“…Triple-negative breast cancers (TNBCs) are aggressive forms of breast carcinoma associated with a high rate of recidivism. In this paper, we report the…”
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Parthenolide generates reactive oxygen species and autophagy in MDA-MB231 cells. A soluble parthenolide analogue inhibits tumour growth and metastasis in a xenograft model of breast cancer
Published in Cell death & disease (01-10-2013)“…Triple-negative breast cancers (TNBCs) are clinically aggressive forms associated with a poor prognosis. We evaluated the cytotoxic effect exerted on…”
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SAHA/TRAIL combination induces detachment and anoikis of MDA-MB231 and MCF-7 breast cancer cells
Published in Biochimie (01-02-2012)“…SAHA, an inhibitor of histone deacetylase activity, has been shown to sensitize tumor cells to apoptosis induced by TRAIL, a member of TNF-family. In this…”
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SAHA induces apoptosis in hepatoma cells and synergistically interacts with the proteasome inhibitor Bortezomib
Published in Apoptosis (London) (01-07-2007)“…Histone deacetylase (HDAC) inhibitors represent a promising group of anticancer agents. This paper shows that the HDAC inhibitor suberoylanilide hydroxamic…”
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JNK and AP-1 mediate apoptosis induced by bortezomib in HepG2 cells via FasL/caspase-8 and mitochondria-dependent pathways
Published in Apoptosis (London) (01-04-2006)“…The proteasome inhibitor bortezomib is an efficacious apoptotic agent in many tumor cells. This paper shows that bortezomib induced apoptosis in human hepatoma…”
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Parthenolide induces superoxide anion production by stimulating EGF receptor in MDA-MB-231 breast cancer cells
Published in International journal of oncology (01-12-2013)“…The sesquiterpene lactone parthenolide (PN) has recently attracted considerable attention because of its antimicrobial, anti-inflammatory and anticancer…”
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The synthetic cannabinoid WIN 55,212-2 sensitizes hepatocellular carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by activating p8/CCAAT/enhancer binding protein homologous protein (CHOP)/death receptor 5 (DR5) axis
Published in Molecular pharmacology (01-05-2010)“…In this article, we demonstrate that the synthetic cannabinoid…”
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Histone deacetylase inhibitors induce in human hepatoma HepG2 cells acetylation of p53 and histones in correlation with apoptotic effects
Published in International journal of oncology (2008)“…This report shows that histone deacetylase inhibitors (HDACIs) induced apoptosis in human hepatoma HepG2 cells in a dose- and time-dependent manner…”
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Sodium butyrate induces apoptosis in human hepatoma cells by a mitochondria/caspase pathway, associated with degradation of β-catenin, pRb and Bcl-X L
Published in European journal of cancer (1990) (01-06-2004)“…Butyrate can promote programmed cell death in a number of tumour cells in vitro. This paper provides evidence that butyrate induces apoptosis in human hepatoma…”
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Sodium butyrate induces apoptosis in human hepatoma cells by a mitochondria/caspase pathway, associated with degradation of β-catenin, pRb and Bcl-XL
Published in European journal of cancer (1990) (01-06-2004)“…Butyrate can promote programmed cell death in a number of tumour cells in vitro. This paper provides evidence that butyrate induces apoptosis in human hepatoma…”
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Differentiative pathway activated by 3-aminobenzamide, an inhibitor of PARP, in human osteosarcoma MG-63 cells
Published in FEBS letters (31-01-2005)“…This study describes the molecular mechanism by which treatment with 3-AB, a potent inhibitor of PARP, allows human osteosarcoma MG-63 cells to restrict growth…”
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Induction of apoptosis in human osteosarcoma Saos-2 cells by the proteasome inhibitor MG132 and the protective effect of pRb
Published in Cell death and differentiation (01-08-2003)Get full text
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Apoptosis induced in hepatoblastoma HepG2 cells by the proteasome inhibitor MG132 is associated with hydrogen peroxide production, expression of Bcl-XS and activation of caspase-3
Published in International journal of oncology (01-10-2002)“…This report is focused on the apoptotic effect induced by MG132, an inhibitor of 26S proteasome, in human hepatoma HepG2 cells. The results were compared with…”
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Induction of Apoptosis by Arachidonic Acid in Human Retinoblastoma Y79 Cells: Involvement of Oxidative Stress
Published in Experimental eye research (01-04-2000)“…Arachidonic acid administration caused apoptosis in Y79 cells, as shown by typical morphological changes, phosphatidylserine externalization, chromatin…”
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The apoptotic effects of cisplatin and carboplatin in retinoblastoma Y79 cells
Published in International journal of oncology (01-08-1998)“…This study demonstrated that cisplatin and carboplatin stimulate apoptosis in human retinoblastoma Y79 cells, cisplatin being the most effective compound. The…”
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Sodium phenylbutyrate induces apoptosis in human retinoblastoma Y79 cells: the effect of combined treatment with the topoisomerase I-inhibitor topotecan
Published in International journal of oncology (01-06-2001)“…Our results demonstrate that sodium phenylbutyrate, a compound with a low degree of toxicity, exerted a cytotoxic effect on human retinoblastoma Y79 cells in a…”
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Histone deacetylase inhibitors : Apoptotic effects and clinical implications (Review)
Published in International journal of oncology (01-10-2008)“…It has been shown that epigenetic modifications play an important role in tumorigenesis. Thus, affecting epigenetic tumorigenic alterations can represent a…”
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Environmental, functional and economic criteria for comparing “target roundabouts” with one- or two-level roundabout intersections
Published in Transportation research. Part D, Transport and environment (01-01-2015)“…•A criterion for comparing conventional with innovative one- or two-level roundabout intersections is presented.•We applied closed-form capacity models and…”
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Insulin-like growth factors in chick embryo retina during development
Published in Regulatory peptides (16-01-1996)“…Evidence exists supporting an important role for insulin-like growth factors (IGFs) during fetal growth. In the present report we performed studies to define…”
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