Search Results - "Tesmer, Valerie M"

Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres by Gu, Peili, Jia, Shuting, Takasugi, Taylor, Tesmer, Valerie M., Nandakumar, Jayakrishnan, Chen, Yong, Chang, Sandy

“…Human shelterin components POT1 and TPP1 form a stable heterodimer that protects telomere ends from ATR-dependent DNA damage responses and regulates…”
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The N Terminus of the OB Domain of Telomere Protein TPP1 Is Critical for Telomerase Action by Grill, Sherilyn, Tesmer, Valerie M., Nandakumar, Jayakrishnan

“…Telomerase recruitment to telomeres and enzymatic processivity are mediated by TPP1, an essential component of telomere integrity and telomerase function. A…”
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Two Separation-of-Function Isoforms of Human TPP1 Dictate Telomerase Regulation in Somatic and Germ Cells by Grill, Sherilyn, Bisht, Kamlesh, Tesmer, Valerie M., Shami, Adrienne Niederriter, Hammoud, Saher S., Nandakumar, Jayakrishnan

“…Telomerase replicates chromosome ends in germ and somatic stem cells to facilitate their continued proliferation. Telomerase action depends on the telomeric…”
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Dissecting the telomere–inner nuclear membrane interface formed in meiosis by Pendlebury, Devon F, Fujiwara, Yasuhiro, Tesmer, Valerie M, Smith, Eric M, Shibuya, Hiroki, Watanabe, Yoshinori, Nandakumar, Jayakrishnan

“…Structural and functional analyses of human TRF1 in complex with meiosis-specific protein TERB1 reveal the basis for telomere tethering to the inner nuclear…”
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Molecular Mechanism for Inhibition of G Protein-Coupled Receptor Kinase 2 by a Selective RNA Aptamer by Tesmer, Valerie M., Lennarz, Sabine, Mayer, Günter, Tesmer, John J.G.

“…Cardiovascular homeostasis is maintained in part by the rapid desensitization of activated heptahelical receptors that have been phosphorylated by…”
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Structural and Functional Analysis of the Regulator of G Protein Signaling 2-Gαq Complex by Nance, Mark R., Kreutz, Barry, Tesmer, Valerie M., Sterne-Marr, Rachel, Kozasa, Tohru, Tesmer, John J.G.

“…The heterotrimeric G protein Gαq is a key regulator of blood pressure, and excess Gαq signaling leads to hypertension. A specific inhibitor of Gαq is the…”
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TPP1 mutagenesis screens unravel shelterin interfaces and functions in hematopoiesis by Grill, Sherilyn, Padmanaban, Shilpa, Friedman, Ann, Perkey, Eric, Allen, Frederick, Tesmer, Valerie M, Chase, Jennifer, Khoriaty, Rami, Keegan, Catherine E, Maillard, Ivan, Nandakumar, Jayakrishnan

“…Telomerase catalyzes chromosome end replication in stem cells and other long-lived cells. Mutations in telomerase or telomere-related genes result in diseases…”
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Human POT1 protects the telomeric ds-ss DNA junction by capping the 5′ end of the chromosome by Tesmer, Valerie M., Brenner, Kirsten A., Nandakumar, Jayakrishnan

“…Protection of telomeres 1 (POT1) is the 3′ single-stranded overhang-binding telomeric protein that prevents an ataxia telangiectasia and Rad3–related (ATR) DNA…”
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The Structure of G Protein-coupled Receptor Kinase (GRK)-6 Defines a Second Lineage of GRKs by Lodowski, David T., Tesmer, Valerie M., Benovic, Jeffrey L., Tesmer, John J.G.

“…We describe the 2.6-Å crystal structure of human G protein-coupled receptor kinase (GRK)-6, a key regulator of dopaminergic signaling and lymphocyte…”
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Structural and functional consequences of a disease mutation in the telomere protein TPP1 by Bisht, Kamlesh, Smith, Eric M., Tesmer, Valerie M., Nandakumar, Jayakrishnan

“…Telomerase replicates chromosome ends to facilitate continued cell division. Mutations that compromise telomerase function result in stem cell failure…”
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Combining conservation and species-specific differences to determine how human telomerase binds telomeres by Tesmer, Valerie M., Smith, Eric M., Danciu, Oana, Padmanaban, Shilpa, Nandakumar, Jayakrishnan

“…Telomerase catalyzes telomeric DNA synthesis at chromosome ends to allow for continued cell division. The telomeric protein TPP1 is essential for enhancing the…”
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Caenorhabditis elegans telomere-binding proteins TEBP-1 and TEBP-2 adapt the Myb module to dimerize and bind telomeric DNA by Padmanaban, Shilpa, Lambacher, Nils J, Tesmer, Valerie M, Zhang, Jingjing, Shibuya, Hiroki, Nandakumar, Jayakrishnan

“…Protecting chromosome ends from misrecognition as double-stranded (ds) DNA breaks is fundamental to eukaryotic viability. The protein complex shelterin…”
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Interaction hub critical for telomerase recruitment and primer-template handling for catalysis by Padmanaban, Shilpa, Tesmer, Valerie M, Nandakumar, Jayakrishnan

“…Telomerase processively adds telomeric DNA repeats to chromosome ends using catalytic protein subunit TERT and a template on its RNA subunit TR. Mammalian…”
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Heterotrimeric G protein β1γ2 subunits change orientation upon complex formation with G protein-coupled receptor kinase 2 (GRK2) on a model membrane by Boughton, Andrew P, Yang, Pei, Tesmer, Valerie M, Ding, Bei, Tesmer, John J. G, Chen, Zhan

“…Few experimental techniques can assess the orientation of peripheral membrane proteins in their native environment. Sum Frequency Generation (SFG) vibrational…”
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An autoinhibitory helix in the C-terminal region of phospholipase C-β mediates Gα q activation by Northup, John K, Tesmer, John J G, Lyon, Angeline M, Tesmer, Valerie M, Dhamsania, Vishan D, Thal, David M, Gutierrez, Joanne, Chowdhury, Shoaib, Suddala, Krishna C

“…By examining the structure of phospholipase C-β, an autoinhibitory helix that interacts with the catalytic core of this enzyme is now identified. Disrupting…”
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Structure of Human G Protein-Coupled Receptor Kinase 2 in Complex with the Kinase Inhibitor Balanol by Tesmer, John J. G, Tesmer, Valerie M, Lodowski, David T, Steinhagen, Henning, Huber, Jochen

“…G protein-coupled receptor kinase 2 (GRK2) is a pharmaceutical target for the treatment of cardiovascular diseases such as congestive heart failure, myocardial…”
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Normal human chromosomes have long G-rich telomeric overhangs at one end by Wright, W E, Tesmer, V M, Huffman, K E, Levene, S D, Shay, J W

“…Telomeres protect the ends of linear chromosomes from degradation and abnormal recombination events, and in vertebrates may be important in cellular senescence…”
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Telomere Shortening Is Proportional to the Size of the G-rich Telomeric 3′-Overhang by Huffman, Kenneth E., Levene, Stephen D., Tesmer, Valerie M., Shay, Jerry W., Wright, Woodring E.

“…Most normal diploid human cells do not express telomerase activity and are unable to maintain telomere length with ongoing cell divisions. We show that the…”
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Assembly of High Order Gαq-Effector Complexes with RGS Proteins by Shankaranarayanan, Aruna, Thal, David M., Tesmer, Valerie M., Roman, David L., Neubig, Richard R., Kozasa, Tohru, Tesmer, John J.G.

“…Transmembrane signaling through Gαq-coupled receptors is linked to physiological processes such as cardiovascular development and smooth muscle function…”
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Heterotrimeric G protein β 1 γ 2 subunits change orientation upon complex formation with G protein-coupled receptor kinase 2 (GRK2) on a model membrane by Boughton, Andrew P., Yang, Pei, Tesmer, Valerie M., Ding, Bei, Tesmer, John J. G., Chen, Zhan

“…Few experimental techniques can assess the orientation of peripheral membrane proteins in their native environment. Sum Frequency Generation (SFG) vibrational…”
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