Search Results - "Tesmer, John JG"

Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4 by Ravala, Sandeep K, Adame-Garcia, Sendi Rafael, Li, Sheng, Chen, Chun-Liang, Cianfrocco, Michael A, Silvio Gutkind, J, Cash, Jennifer N, Tesmer, John JG

“…PIP 3 -dependent Rac exchanger 1 (P-Rex1) is abundantly expressed in neutrophils and plays central roles in chemotaxis and cancer metastasis by serving as a…”
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Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol by Manthei, Kelly A, Yang, Shyh-Ming, Baljinnyam, Bolormaa, Chang, Louise, Glukhova, Alisa, Yuan, Wenmin, Freeman, Lita A, Maloney, David J, Schwendeman, Anna, Remaley, Alan T, Jadhav, Ajit, Tesmer, John Jg

“…Lecithin:cholesterol acyltransferase (LCAT) and LCAT-activating compounds are being investigated as treatments for coronary heart disease (CHD) and familial…”
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C-terminal threonines and serines play distinct roles in the desensitization of rhodopsin, a G protein-coupled receptor by Azevedo, Anthony W, Doan, Thuy, Moaven, Hormoz, Sokal, Iza, Baameur, Faiza, Vishnivetskiy, Sergey A, Homan, Kristoff T, Tesmer, John J G, Gurevich, Vsevolod V, Chen, Jeannie, Rieke, Fred

“…Rod photoreceptors generate measurable responses to single-photon activation of individual molecules of the G protein-coupled receptor (GPCR), rhodopsin…”
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Hitchhiking on the heptahelical highway: structure and function of 7TM receptor complexes by Tesmer, John J. G.

“…Key Points Since 2007, the number of high-resolution studies of seven transmembrane domain (7TM) receptors (including G protein-coupled receptors) has greatly…”
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Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4 by Ravala, Sandeep K, Adame-Garcia, Sendi Rafael, Li, Sheng, Chen, Chun-Liang, Cianfrocco, Michael A, Silvio Gutkind, J, Cash, Jennifer N, Tesmer, John JG

“…PIP 3 -dependent Rac exchanger 1 (P-Rex1) is abundantly expressed in neutrophils and plays central roles in chemotaxis and cancer metastasis by serving as a…”
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Structural insights into G protein-coupled receptor kinase function by Homan, Kristoff T, Tesmer, John JG

“…The atomic structure of a protein can greatly advance our understanding of molecular recognition and catalysis, properties of fundamental importance in signal…”
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Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase by Glukhova, Alisa, Hinkovska-Galcheva, Vania, Kelly, Robert, Abe, Akira, Shayman, James A., Tesmer, John J. G.

“…Lysosomal phospholipase A2 (LPLA2) and lecithin:cholesterol acyltransferase (LCAT) belong to a structurally uncharacterized family of key lipid-metabolizing…”
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Monomeric Rhodopsin Is Sufficient for Normal Rhodopsin Kinase (GRK1) Phosphorylation and Arrestin-1 Binding by Bayburt, Timothy H., Vishnivetskiy, Sergey A., McLean, Mark A., Morizumi, Takefumi, Huang, Chih-chin, Tesmer, John J.G., Ernst, Oliver P., Sligar, Stephen G., Gurevich, Vsevolod V.

“…G-protein-coupled receptor (GPCR) oligomerization has been observed in a wide variety of experimental contexts, but the functional significance of this…”
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Structural and Functional Analysis of the Regulator of G Protein Signaling 2-Gαq Complex by Nance, Mark R., Kreutz, Barry, Tesmer, Valerie M., Sterne-Marr, Rachel, Kozasa, Tohru, Tesmer, John J.G.

“…The heterotrimeric G protein Gαq is a key regulator of blood pressure, and excess Gαq signaling leads to hypertension. A specific inhibitor of Gαq is the…”
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Molecular Mechanism for Inhibition of G Protein-Coupled Receptor Kinase 2 by a Selective RNA Aptamer by Tesmer, Valerie M., Lennarz, Sabine, Mayer, Günter, Tesmer, John J.G.

“…Cardiovascular homeostasis is maintained in part by the rapid desensitization of activated heptahelical receptors that have been phosphorylated by…”
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Structures of Rhodopsin Kinase in Different Ligand States Reveal Key Elements Involved in G Protein-coupled Receptor Kinase Activation by Singh, Puja, Wang, Benlian, Maeda, Tadao, Palczewski, Krzysztof, Tesmer, John J.G.

“…G protein-coupled receptor (GPCR) kinases (GRKs) phosphorylate activated heptahelical receptors, leading to their uncoupling from G proteins. Here we report…”
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Structural Determinants of RhoA Binding and Nucleotide Exchange in Leukemia-associated Rho Guanine-Nucleotide Exchange Factor by Kristelly, Romana, Gao, Guang, Tesmer, John J G

“…Rho guanine-nucleotide exchange factors (RhoGEFs) activate Rho GTPases, and thereby regulate cytoskeletal structure, gene transcription, and cell migration…”
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Synthesis of deuterium‐labelled amlexanox and its metabolic stability against mouse, rat, and human microsomes by Gan, Xinmin, Wilson, Michael W., Beyett, Tyler S., Wen, Bo, Sun, Duxin, Larsen, Scott D., Tesmer, John J.G., Saltiel, Alan R., Showalter, Hollis D.

“…As part of a program toward making analogues of amlexanox (1), currently under clinical investigation for the treatment of type 2 diabetes and obesity, we have…”
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The Structure of G Protein-coupled Receptor Kinase (GRK)-6 Defines a Second Lineage of GRKs by Lodowski, David T., Tesmer, Valerie M., Benovic, Jeffrey L., Tesmer, John J.G.

“…We describe the 2.6-Å crystal structure of human G protein-coupled receptor kinase (GRK)-6, a key regulator of dopaminergic signaling and lymphocyte…”
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Substrate-Induced Changes in the Dynamics of Rhodopsin Kinase (G Protein-Coupled Receptor Kinase 1) by Orban, Tivadar, Huang, Chih-chin, Homan, Kristoff T., Jastrzebska, Beata, Tesmer, John J. G., Palczewski, Krzysztof

“…G protein-coupled receptor (GPCR) kinases (GRKs) instigate the desensitization of activated GPCRs via phosphorylation that promotes interaction with arrestins,…”
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New Therapeutics Targeting Heart Failure: Development of GRK2 Selective Inhibitors by Homan, Kristoff T, Thal, David M, Wu, Emily, Chen, Jun, Sklar, Larry, Tesmer, John JG

“…Abstract only Heart failure is a leading cause of death in adults throughout the world. One of the defining characteristics of heart failure is dysregulation…”
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Structural analysis of thermostabilizing mutations of cocaine esterase by Narasimhan, Diwahar, Nance, Mark R., Gao, Daquan, Ko, Mei-Chuan, Macdonald, Joanne, Tamburi, Patricia, Yoon, Dan, Landry, Donald M., Woods, James H., Zhan, Chang-Guo, Tesmer, John J.G., Sunahara, Roger K.

“…Cocaine is considered to be the most addictive of all substances of abuse and mediates its effects by inhibiting monoamine transporters, primarily the dopamine…”
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Paroxetine-Mediated GRK2 Inhibition Reverses Cardiac Dysfunction and Remodeling After Myocardial Infarction by Schumacher, Sarah M, Gao, Erhe, Zhu, Weizhong, Chen, Xiongwen, Chuprun, J. Kurt, Feldman, Arthur M, Tesmer, John JG, Koch, Walter J

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Structure of an activated G protein‐coupled receptor kinase reveals its receptor‐docking domain by Tesmer, John JG, Singh, Puja, Huang, Chih‐chin

“…Abstract only…”
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Heterotrimeric G protein β 1 γ 2 subunits change orientation upon complex formation with G protein-coupled receptor kinase 2 (GRK2) on a model membrane by Boughton, Andrew P., Yang, Pei, Tesmer, Valerie M., Ding, Bei, Tesmer, John J. G., Chen, Zhan

“…Few experimental techniques can assess the orientation of peripheral membrane proteins in their native environment. Sum Frequency Generation (SFG) vibrational…”
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