Search Results - "Teslaa, Tara"

Quantitative Fluxomics of Circulating Metabolites by Hui, Sheng, Cowan, Alexis J., Zeng, Xianfeng, Yang, Lifeng, TeSlaa, Tara, Li, Xiaoxuan, Bartman, Caroline, Zhang, Zhaoyue, Jang, Cholsoon, Wang, Lin, Lu, Wenyun, Rojas, Jennifer, Baur, Joseph, Rabinowitz, Joshua D.

“…Mammalian organs are nourished by nutrients carried by the blood circulation. These nutrients originate from diet and internal stores, and can undergo various…”
Get full text

A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway by Ghergurovich, Jonathan M., García-Cañaveras, Juan C., Wang, Joshua, Schmidt, Emily, Zhang, Zhaoyue, TeSlaa, Tara, Patel, Harshel, Chen, Li, Britt, Emily C., Piqueras-Nebot, Marta, Gomez-Cabrera, Mari Carmen, Lahoz, Agustín, Fan, Jing, Beier, Ulf H., Kim, Hahn, Rabinowitz, Joshua D.

“…Glucose is catabolized by two fundamental pathways, glycolysis to make ATP and the oxidative pentose phosphate pathway to make reduced nicotinamide adenine…”
Get full text

The Source of Glycolytic Intermediates in Mammalian Tissues by TeSlaa, Tara, Bartman, Caroline R., Jankowski, Connor S.R., Zhang, Zhaoyue, Xu, Xincheng, Xing, Xi, Wang, Lin, Lu, Wenyun, Hui, Sheng, Rabinowitz, Joshua D.

“…Glycolysis plays a central role in organismal metabolism, but its quantitative inputs across mammalian tissues remain unclear. Here we use 13C-tracing in mice…”
Get full text

Spatially resolved isotope tracing reveals tissue metabolic activity by Wang, Lin, Xing, Xi, Zeng, Xianfeng, Jackson, S. RaElle, TeSlaa, Tara, Al-Dalahmah, Osama, Samarah, Laith Z., Goodwin, Katharine, Yang, Lifeng, McReynolds, Melanie R., Li, Xiaoxuan, Wolff, Jeremy J., Rabinowitz, Joshua D., Davidson, Shawn M.

“…Isotope tracing has helped to determine the metabolic activities of organs. Methods to probe metabolic heterogeneity within organs are less developed. We…”
Get full text

Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer by Pate, Kira T, Stringari, Chiara, Sprowl-Tanio, Stephanie, Wang, Kehui, TeSlaa, Tara, Hoverter, Nate P, McQuade, Miriam M, Garner, Chad, Digman, Michelle A, Teitell, Michael A, Edwards, Robert A, Gratton, Enrico, Waterman, Marian L

“…Much of the mechanism by which Wnt signaling drives proliferation during oncogenesis is attributed to its regulation of the cell cycle. Here, we show how…”
Get full text

Lactate Limits T Cell Proliferation via the NAD(H) Redox State by Quinn, William J., Jiao, Jing, TeSlaa, Tara, Stadanlick, Jason, Wang, Zhonglin, Wang, Liqing, Akimova, Tatiana, Angelin, Alessia, Schäfer, Patrick M., Cully, Michelle D., Perry, Caroline, Kopinski, Piotr K., Guo, Lili, Blair, Ian A., Ghanem, Louis R., Leibowitz, Michael S., Hancock, Wayne W., Moon, Edmund K., Levine, Matthew H., Eruslanov, Evgeniy B., Wallace, Douglas C., Baur, Joseph A., Beier, Ulf H.

“…Immune cell function is influenced by metabolic conditions. Low-glucose, high-lactate environments, such as the placenta, gastrointestinal tract, and the tumor…”
Get full text

Mitochondrial Transfer by Photothermal Nanoblade Restores Metabolite Profile in Mammalian Cells by Wu, Ting-Hsiang, Sagullo, Enrico, Case, Dana, Zheng, Xin, Li, Yanjing, Hong, Jason S., TeSlaa, Tara, Patananan, Alexander N., McCaffery, J. Michael, Niazi, Kayvan, Braas, Daniel, Koehler, Carla M., Graeber, Thomas G., Chiou, Pei-Yu, Teitell, Michael A.

“…mtDNA sequence alterations are challenging to generate but desirable for basic studies and potential correction of mtDNA diseases. Here, we report a new method…”
Get full text

Dissection of the Burkholderia intracellular life cycle using a photothermal nanoblade by French, Christopher T, Toesca, Isabelle J, Wu, Ting-Hsiang, Teslaa, Tara, Beaty, Shannon M, Wong, Wayne, Liu, Minghsun, Schröder, Imke, Chiou, Pei-Yu, Teitell, Michael A, Miller, Jeff F

“…Burkholderia pseudomallei and Burkholderia thailandensis are related pathogens that invade a variety of cell types, replicate in the cytoplasm, and spread to…”
Get full text

PNPase knockout results in mtDNA loss and an altered metabolic gene expression program by Shimada, Eriko, Ahsan, Fasih M, Nili, Mahta, Huang, Dian, Atamdede, Sean, TeSlaa, Tara, Case, Dana, Yu, Xiang, Gregory, Brian D, Perrin, Benjamin J, Koehler, Carla M, Teitell, Michael A

“…Polynucleotide phosphorylase (PNPase) is an essential mitochondria-localized exoribonuclease implicated in multiple biological processes and human disorders…”
Get full text

Photothermal nanoblade for patterned cell membrane cutting by Wu, Ting-Hsiang, Teslaa, Tara, Teitell, Michael A, Chiou, Pei-Yu

“…We report a photothermal nanoblade that utilizes a metallic nanostructure to harvest short laser pulse energy and convert it into a highly localized and…”
Get full text

1923-P: Quantitative Measurement of Whole-Body Glycogen Metabolism and Gluconeogenic Flux by TESLAA, TARA

“…Circulating glucose levels are maintained during fasting by endogenous production of glucose through: 1) the breakdown of glycogen and 2) from gluconeogenesis…”
Get full text

Metformin induces a Lac-Phe gut–brain signalling axis by TeSlaa, Tara

“…The mechanism by which metformin affects food intake remains controversial. Now, two studies link metformin treatment with the induction of the…”
Get full text

Pluripotent stem cell energy metabolism: an update by Teslaa, Tara, Teitell, Michael A

“…Recent studies link changes in energy metabolism with the fate of pluripotent stem cells (PSCs). Safe use of PSC derivatives in regenerative medicine requires…”
Get full text

Techniques to monitor glycolysis by TeSlaa, Tara, Teitell, Michael A

“…An increased flux through glycolysis supports the proliferation of cancer cells by providing additional energy in the form of ATP as well as glucose-derived…”
Get more information

The pentose phosphate pathway in health and disease by TeSlaa, Tara, Ralser, Markus, Fan, Jing, Rabinowitz, Joshua D.

“…The pentose phosphate pathway (PPP) is a glucose-oxidizing pathway that runs in parallel to upper glycolysis to produce ribose 5-phosphate and nicotinamide…”
Get full text

Slow TCA flux and ATP production in primary solid tumours but not metastases by Bartman, Caroline R., Weilandt, Daniel R., Shen, Yihui, Lee, Won Dong, Han, Yujiao, TeSlaa, Tara, Jankowski, Connor S. R., Samarah, Laith, Park, Noel R., da Silva-Diz, Victoria, Aleksandrova, Maya, Gultekin, Yetis, Marishta, Argit, Wang, Lin, Yang, Lifeng, Roichman, Asael, Bhatt, Vrushank, Lan, Taijin, Hu, Zhixian, Xing, Xi, Lu, Wenyun, Davidson, Shawn, Wühr, Martin, Vander Heiden, Matthew G., Herranz, Daniel, Guo, Jessie Yanxiang, Kang, Yibin, Rabinowitz, Joshua D.

“…Tissues derive ATP from two pathways—glycolysis and the tricarboxylic acid (TCA) cycle coupled to the electron transport chain. Most energy in mammals is…”
Get full text

α-Ketoglutarate Accelerates the Initial Differentiation of Primed Human Pluripotent Stem Cells by TeSlaa, Tara, Chaikovsky, Andrea C., Lipchina, Inna, Escobar, Sandra L., Hochedlinger, Konrad, Huang, Jing, Graeber, Thomas G., Braas, Daniel, Teitell, Michael A.

“…Pluripotent stem cells (PSCs) can self-renew or differentiate from naive or more differentiated, primed, pluripotent states established by specific culture…”
Get full text

Mitochondria in human pluripotent stem cell apoptosis by TeSlaa, Tara, Setoguchi, Kiyoko, Teitell, Michael A.

“…Human pluripotent stem cells (hPSCs) have great potential in regenerative medicine because they can differentiate into any cell type in the body. Genome…”
Get full text

PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism by Stine, Rachel R., Sakers, Alexander P., TeSlaa, Tara, Kissig, Megan, Stine, Zachary E., Kwon, Chan Wook, Cheng, Lan, Lim, Hee-Woong, Kaestner, Klaus H., Rabinowitz, Joshua D., Seale, Patrick

“…Metabolic pathways dynamically regulate tissue development and maintenance. However, the mechanisms that govern the metabolic adaptation of stem or progenitor…”
Get full text

Quantitative flux analysis in mammals by Bartman, Caroline R., TeSlaa, Tara, Rabinowitz, Joshua D.

“…Altered metabolic activity contributes to the pathogenesis of a number of diseases, including diabetes, heart failure, cancer, fibrosis and neurodegeneration…”
Get full text