Search Results - "Teske, Jacob J."
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Aging increases senescence, calcium signaling, and extracellular matrix deposition in human airway smooth muscle
Published in PloS one (29-07-2021)“…Lung function declines as people age and their lungs become stiffer. With an increasing elderly population, understanding mechanisms that contribute to these…”
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Asthmatic lung fibroblasts promote type 2 immune responses via endoplasmic reticulum stress response dependent thymic stromal lymphopoietin secretion
Published in Frontiers in physiology (25-01-2023)“…Lung fibroblasts contribute to asthma pathology partly through modulation of the immune environment in the airway. Tumor necrosis factor-α (TNFα) expression is…”
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MIBlood‐EV: Minimal information to enhance the quality and reproducibility of blood extracellular vesicle research
Published in Journal of extracellular vesicles (01-12-2023)“…Blood is the most commonly used body fluid for extracellular vesicle (EV) research. The composition of a blood sample and its derivatives (i.e., plasma and…”
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Age-associated differences in the human lung extracellular matrix
Published in American journal of physiology. Lung cellular and molecular physiology (01-06-2023)“…Extracellular matrix (ECM) remodeling has been associated with chronic lung diseases. However, information about specific age-associated differences in lung…”
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Moderate hyperoxia induces senescence in developing human lung fibroblasts
Published in American journal of physiology. Lung cellular and molecular physiology (01-11-2019)“…Hyperoxia exposure in premature infants increases the risk of subsequent lung diseases, such as asthma and bronchopulmonary dysplasia. Fibroblasts help…”
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Cellular senescence is increased in airway smooth muscle cells of elderly persons with asthma
Published in American journal of physiology. Lung cellular and molecular physiology (01-11-2022)“…Senescent cells can drive age-related tissue dysfunction partially via a senescence-associated secretory phenotype (SASP) involving proinflammatory and…”
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Functional α7 nicotinic receptors in human airway smooth muscle increase intracellular calcium concentration and contractility in asthmatics
Published in American journal of physiology. Lung cellular and molecular physiology (01-07-2023)“…Although nicotinic acetylcholine receptors (nAChRs) are commonly associated with neurons in the brain and periphery, recent data indicate that they are also…”
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Glial‐derived neurotrophic factor in human airway smooth muscle
Published in Journal of cellular physiology (01-12-2021)“…Airway smooth muscle (ASM) cells modulate the local airway milieu via production of inflammatory mediators and growth factors including classical…”
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Neurotrophin Regulation and Signaling in Airway Smooth Muscle
Published in Advances in experimental medicine and biology (01-01-2021)“…Structural and functional aspects of bronchial airways are key throughout life and play critical roles in diseases such as asthma. Asthma involves functional…”
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Calcium sensing receptor in developing human airway smooth muscle
Published in Journal of cellular physiology (01-08-2019)“…Airway smooth muscle (ASM) regulation of airway structure and contractility is critical in fetal/neonatal physiology in health and disease. Fetal lungs…”
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