Search Results - "Tesar, B"

Effects of Charge on Antibody Tissue Distribution and Pharmacokinetics by Boswell, C. Andrew, Tesar, Devin B., Mukhyala, Kiran, Theil, Frank-Peter, Fielder, Paul J., Khawli, Leslie A.

“…Antibody pharmacokinetics and pharmacodynamics are often governed by biological processes such as binding to antigens and other cognate receptors. Emphasis…”
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A Review of Protein- and Peptide-Based Chemical Conjugates: Past, Present, and Future by Holz, Emily, Darwish, Martine, Tesar, Devin B, Shatz-Binder, Whitney

“…Over the past few decades, the complexity of molecular entities being advanced for therapeutic purposes has continued to evolve. A main propellent fueling…”
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The Role of Hyaluronan Degradation Products as Innate Alloimmune Agonists by Tesar, B. M., Jiang, D., Liang, J., Palmer, S. M., Noble, P. W., Goldstein, D. R.

“…Dendritic cells (DCs) play a key role in initiating alloimmunity yet the substances that activate them during the host response to transplantation remain…”
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Intracellular neutralization of viral infection in polarized epithelial cells by neonatal Fc receptor (FcRn)-mediated IgG transport by Bai, Yu, Ye, Lilin, Tesar, Devin B, Song, Haichen, Zhao, Deming, Björkman, Pamela J, Roopenian, Derry C, Zhu, Xiaoping

“…IgG was traditionally thought to neutralize virions by blocking their attachment to or penetration into mucosal epithelial cells, a common site of exposure to…”
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The chicken yolk sac IgY receptor, a mammalian mannose receptor family member, transcytoses IgY across polarized epithelial cells by Tesar, Devin B, Cheung, Evelyn J, Bjorkman, Pamela J

“…In mammals the transfer of passive immunity from mother to young is mediated by the MHC-related receptor FcRn, which transports maternal IgG across epithelial…”
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Ligand Valency Affects Transcytosis, Recycling and Intracellular Trafficking Mediated by the Neonatal Fc Receptor by Tesar, Devin B., Tiangco, Noreen E., Bjorkman, Pamela J.

“…The neonatal Fc receptor (FcRn) transports IgG across epithelial cell barriers to provide maternal antibodies to offspring and serves as a protection receptor…”
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Aging Augments IL‐17 T‐Cell Alloimmune Responses by Tesar, B. M., Du, W., Shirali, A. C., Walker, W. E., Shen, H., Goldstein, D. R.

“…As increasing numbers of elderly patients require solid organ transplantation, the need to better understand how aging modifies alloimmune responses increases…”
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Charge variants in IgG1: Isolation, characterization, in vitro binding properties and pharmacokinetics in rats by Khawli, Leslie A., Goswami, Sirj, Hutchinson, Ryan, Kwong, Zephania W., Yang, Jihong, Wang, Xiangdan, Yao, Zhenling, Sreedhara, Alavattam, Cano, Tony, Tesar, Devin B., Nijem, Ihsan, Allison, David E., Wong, Pin Yee, Kao, Yung-Hsiang, Quan, Cynthia, Joshi, Amita, Harris, Reed J., Motchnik, Paul

“…Antibody charge variants have gained considerable attention in the biotechnology industry due to their potential influence on stability and biological…”
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A freeze substitution fixation-based gold enlarging technique for EM studies of endocytosed Nanogold-labeled molecules by He, Wanzhong, Kivork, Christine, Machinani, Suman, Morphew, Mary K., Gail, Anna M., Tesar, Devin B., Tiangco, Noreen E., McIntosh, J. Richard, Bjorkman, Pamela J.

“…We have developed methods to locate individual ligands that can be used for electron microscopy studies of dynamic events during endocytosis and subsequent…”
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Selective Uptake of Macromolecules to the Brain in Microfluidics and Animal Models Using the HAVN1 Peptide as a Blood-Brain Barrier Modulator by Schwinghamer, Kelly, Line, Stacey, Tesar, Devin B., Miller, Donald W., Sreedhara, Alavattam, Siahaan, Teruna J.

“…Monoclonal antibodies (mAbs) possess favorable pharmacokinetic properties, high binding specificity and affinity, and minimal off-target effects, making them…”
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Germline copy number variation associated with Mendelian inheritance of CLL in two families by Brown, J R, Hanna, M, Tesar, B, Pochet, N, Vartanov, A, Fernandes, S M, Werner, L, Ash, M, Roden, C A, MacConaill, L, Hainz, U, Longtine, J, Wang, Y E, Correll, M, Van de Peer, Y, Regev, A, Wu, C, Neuberg, D, Freedman, A S

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Protein conjugates and fusion proteins as ocular therapeutics by Mehta, Shrenik C., Kelley, Robert F., Tesar, Devin B.

“…•Current treatments for AMD and the need for LAD are summarized.•Key considerations for development of LAD technologies are detailed.•Currently marketed…”
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Exploring How Antibody Format Drives Clearance from the Brain by Schwinghamer, Kelly, Kopec, Brian M., Ayewoh, Ebehiremen, Tao, Xun, Sadekar, Shraddha, Sreedhara, Alavattam, Kelley, Robert F., Tesar, Devin B., Siahaan, Teruna J.

“…Monoclonal antibodies (mAbs) have high binding specificity and affinity, making them attractive for treating brain diseases. However, their effectiveness is…”
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Generation of a Porcine Antibody Fab Fragment Using Protein Engineering to Facilitate the Evaluation of Ocular Sustained Delivery Technology by Kelley, Robert F, Tesar, Devin B, Wang, Yue, Agard, Nicholas J, Holder, Patrick G, Chan, Joyce, Comps-Agrar, Laetitia, Horvath, Judit, Horvath, Joshua D, Crowell, Susan R

“…Treatment of age-related macular degeneration (AMD) with anti-vascular endothelial growth factor (VEGF) biologic agents has been shown to restore and maintain…”
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Quantitative cumulative biodistribution of antibodies in mice: Effect of modulating binding affinity to the neonatal Fc receptor by Yip, Victor, Palma, Enzo, Tesar, Devin B, Mundo, Eduardo E, Bumbaca, Daniela, Torres, Elizabeth K, Reyes, Noe A, Shen, Ben Q, Fielder, Paul J, Prabhu, Saileta, Khawli, Leslie A, Boswell, C Andrew

“…The neonatal Fc receptor (FcRn) plays an important and well-known role in antibody recycling in endothelial and hematopoietic cells and thus it influences the…”
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An intracellular traffic jam: Fc receptor-mediated transport of immunoglobulin G by Tesar, Devin B, Björkman, Pamela J

“…Recent advances in imaging techniques along with more powerful in vitro and in vivo models of receptor-mediated ligand transport are facilitating advances in…”
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Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration by Zheng, Yanan, Tesar, Devin B., Benincosa, Lisa, Birnböck, Herbert, Boswell, C. Andrew, Bumbaca, Daniela, Cowan, Kyra J, Danilenko, Dimitry M., Daugherty, Ann L., Fielder, Paul J., Grimm, Hans Peter, Joshi, Amita, Justies, Nicole, Kolaitis, Gerry, Lewin-Koh, Nicholas, Li, Jing, McVay, Sami, O'Mahony, Jennifer, Otteneder, Michael, Pantze, Michael, Putnam, Wendy S., Qiu, Zhihua J., Ruppel, Jane, Singer, Thomas, Stauch, Oliver, Theil, Frank-Peter, Visich, Jennifer, Yang, Jihong, Ying, Yong, Khawli, Leslie A., Richter, Wolfgang F.

“…Subcutaneous (SC) delivery is a common route of administration for therapeutic monoclonal antibodies (mAbs) with pharmacokinetic (PK)/pharmacodynamic (PD)…”
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Comparison of FcRn- and pIgR-Mediated Transport in MDCK Cells by Fluorescence Confocal Microscopy by Jerdeva, Galina V, Tesar, Devin B, Huey-Tubman, Kathryn E, Ladinsky, Mark S, Fraser, Scott E, Bjorkman, Pamela J

“…Protein delivery across polarized epithelia is controlled by receptor-mediated transcytosis. Many studies have examined basolateral-to-apical trafficking of…”
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Learning optimality-theoretic grammars by Tesar, Bruce B., Smolensky, Paul

“…We present evidence that Optimality Theory's account of Universal Grammar has manifold implications for learning. The general principles of Optimality Theory…”
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Toll-like receptors and allograft rejection by Goldstein, Daniel R, Tesar, Bethany M

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