Search Results - "Teruna J. Siahaan"

Doxorubicin-loaded iron oxide nanoparticles for glioblastoma therapy: a combinational approach for enhanced delivery of nanoparticles by Norouzi, Mohammad, Yathindranath, Vinith, Thliveris, James A., Kopec, Brian M., Siahaan, Teruna J., Miller, Donald W.

“…Although doxorubicin (DOX) is an effective anti-cancer drug with cytotoxicity in a variety of different tumors, its effectiveness in treating glioblastoma…”
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Protein PEGylation for cancer therapy: bench to bedside by Gupta, Vijayalaxmi, Bhavanasi, Sneha, Quadir, Mohiuddin, Singh, Kevin, Ghosh, Gaurav, Vasamreddy, Kritin, Ghosh, Arnab, Siahaan, Teruna J., Banerjee, Snigdha, Banerjee, Sushanta K.

“…PEGylation is a biochemical modification process of bioactive molecules with polyethylene glycol (PEG), which lends several desirable properties to…”
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Enhancing Antibody Exposure in the Central Nervous System: Mechanisms of Uptake, Clearance, and Strategies for Improved Brain Delivery by Schwinghamer, Kelly, Siahaan, Teruna J.

“…Antibodies (mAbs) are attractive molecules for their application as a diagnostic and therapeutic agent for diseases of the central nervous system (CNS). mAbs…”
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ICAM-1 targeting of doxorubicin-loaded PLGA nanoparticles to lung epithelial cells by Chittasupho, Chuda, Xie, Sheng-Xue, Baoum, Abdulgader, Yakovleva, Tatyana, Siahaan, Teruna J., Berkland, Cory J.

“…Interaction of leukocyte function associated antigen-1 (LFA-1) on T-lymphoctytes and intercellular adhesion molecule-1 (ICAM-1) on epithelial cells controls…”
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M. tuberculosis Transcription Machinery: A Review on the Mycobacterial RNA Polymerase and Drug Discovery Efforts by Stephanie, Filia, Tambunan, Usman Sumo Friend, Siahaan, Teruna J

“…(MTB) is the main source of tuberculosis (TB), one of the oldest known diseases in the human population. Despite the drug discovery efforts of past decades, TB…”
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Pathways and progress in improving drug delivery through the intestinal mucosa and blood-brain barriers by Laksitorini, Marlyn, Prasasty, Vivitri D, Kiptoo, Paul K, Siahaan, Teruna J

“…One of the major hurdles in developing therapeutic agents is the difficulty in delivering drugs through the intestinal mucosa and blood-brain barriers (BBB)…”
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Methotrexate disposition, anti-folate activity and efficacy in the collagen-induced arthritis mouse model by Singh, Rakesh K., van Haandel, Leon, Kiptoo, Paul, Becker, Mara L., Siahaan, Teruna J., Funk, Ryan S.

“…Methotrexate (MTX) efficacy in autoimmune arthritis is variable and unpredictable resulting in the need for the identification of biomarkers to guide drug…”
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Controlling ligand surface density optimizes nanoparticle binding to ICAM-1 by Fakhari, Amir, Baoum, Abdulgader, Siahaan, Teruna J, Le, Khoi Ba, Berkland, Cory

“…During infection, pathogens utilize surface receptors to gain entry into intracellular compartments. Multiple receptor-ligand interactions that lead to…”
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Improving In Vivo Brain Delivery of Monoclonal Antibody Using Novel Cyclic Peptides by Ulapane, Kavisha R, Kopec, Brian M, Siahaan, Teruna J

“…Many proteins can be used to treat brain diseases; however, the presence of the blood-brain barrier (BBB) creates an obstacle to delivering them into the…”
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Conjugates of Cell Adhesion Peptides for Therapeutics and Diagnostics Against Cancer and Autoimmune Diseases by Moral, Mario E G, Siahaan, Teruna J

“…Overexpressed cell-surface receptors are hallmarks of many disease states and are often used as markers for targeting diseased cells over healthy counterparts…”
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Structural Design and Synthesis of Novel Cyclic Peptide Inhibitors Targeting Mycobacterium tuberculosis Transcription by Stephanie, Filia, Saragih, Mutiara, Tambunan, Usman Sumo Friend, Siahaan, Teruna J.

“…Tuberculosis (TB) remains one of the deadliest infectious diseases in the world. Although several established antitubercular drugs have been found, various…”
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Brain Delivery of Drug and MRI Contrast Agent: Detection and Quantitative Determination of Brain Deposition of CPT-Glu Using LC–MS/MS and Gd-DTPA Using Magnetic Resonance Imaging by Tabanor, Kayann, Lee, Phil, Kiptoo, Paul, Choi, In-Young, Sherry, Erica B, Eagle, Cheyenne Sun, Williams, Todd D, Siahaan, Teruna J

“…Successful treatment and diagnosis of neurological diseases depend on reliable delivery of molecules across the blood–brain barrier (BBB), which restricts…”
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Inhibition of LFA-1/ICAM-1 and VLA-4/VCAM-1 as a therapeutic approach to inflammation and autoimmune diseases by Yusuf-Makagiansar, Helena, Anderson, Meagan E., Yakovleva, Tatyana V., Murray, Joseph S., Siahaan, Teruna J.

“…This review focuses on providing insights into the structural basis and clinical relevance of LFA‐1 and VLA‐4 inhibition by peptides and small molecules as…”
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Validation of Cadherin HAV6 Peptide in the Transient Modulation of the Blood-Brain Barrier for the Treatment of Brain Tumors by Sajesh, Babu V., On, Ngoc H., Omar, Refaat, Alrushaid, Samaa, Kopec, Brian M., Wang, Wei-Guang, Sun, Han-Dong, Lillico, Ryan, Lakowski, Ted M., Siahaan, Teruna J., Davies, Neal M., Puno, Pema-Tenzin, Vanan, Magimairajan Issai, Miller, Donald W.

“…The blood-brain barrier (BBB) poses a major obstacle by preventing potential therapeutic agents from reaching their intended brain targets at sufficient…”
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Peptide-mediated targeted drug delivery by Majumdar, Sumit, Siahaan, Teruna J.

“…Targeted drug delivery to specific group of cells offers an attractive strategy to minimize the undesirable side effects and achieve the therapeutic effect…”
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Targeting ICAM-1/LFA-1 interaction for controlling autoimmune diseases: designing peptide and small molecule inhibitors by Anderson, Meagan E., Siahaan, Teruna J.

“…This review describes the role of modulation of intracellular adhesion molecule-1 (ICAM-1)/leukocyte function-associated antigen-1 (LFA-1) interaction in…”
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Antigen-specific suppression of experimental autoimmune encephalomyelitis by a novel bifunctional peptide inhibitor by Kobayashi, Naoki, Kobayashi, Hitomi, Gu, Leo, Malefyt, Thomas, Siahaan, Teruna J

“…The objective of this study is to evaluate the activity of a novel peptide, i.e., bifunctional peptide inhibitor (BPI), which targets the immunological synapse…”
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Improving Brain Delivery of Biomolecules via BBB Modulation in Mouse and Rat: Detection using MRI, NIRF, and Mass Spectrometry by Ulapane, Kavisha R, On, Ngoc, Kiptoo, Paul, Williams, Todd D, Miller, Donald W, Siahaan, Teruna J

“…There is an urgent need to develop new and alternative methods to deliver functional biomolecules to the brain for diagnosis and treatment of brain diseases…”
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Codelivery of antigen and an immune cell adhesion inhibitor is necessary for efficacy of soluble antigen arrays in experimental autoimmune encephalomyelitis by Sestak, Joshua O, Sullivan, Bradley P, Thati, Sharadvi, Northrup, Laura, Hartwell, Brittany, Antunez, Lorena, Forrest, M Laird, Vines, Charlotte M, Siahaan, Teruna J, Berkland, Cory

“…Autoimmune diseases such as multiple sclerosis (MS) are typified by the misrecognition of self-antigen and the clonal expansion of autoreactive T cells…”
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Noninvasive Brain Delivery and Efficacy of BDNF to Stimulate Neuroregeneration and Suppression of Disease Relapse in EAE Mice by Kopec, Brian M, Kiptoo, Paul, Zhao, Liqin, Rosa-Molinar, Eduardo, Siahaan, Teruna J

“…The number of FDA-approved protein drugs (biologics), such as antibodies, antibody–drug conjugates, hormones, and enzymes, continues to grow at a rapid rate;…”
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