Search Results - "Territo, Paul R"

P2X7 Receptors in Neurodegeneration: Potential Therapeutic Applications From Basic to Clinical Approaches by Territo, Paul R., Zarrinmayeh, Hamideh

“…Purinergic receptors play important roles in central nervous system (CNS), where the bulk of these receptors are implicated in neuroinflammatory responses and…”
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Purinergic Receptors of the Central Nervous System: Biology, PET Ligands, and Their Applications by Zarrinmayeh, Hamideh, Territo, Paul R.

“…Purinergic receptors play important roles in central nervous system (CNS). These receptors are involved in cellular neuroinflammatory responses that regulate…”
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Quantitative MR Evaluation of Chronic Pancreatitis: Extracellular Volume Fraction and MR Relaxometry by Tirkes, Temel, Lin, Chen, Cui, Enming, Deng, Yu, Territo, Paul R, Sandrasegaran, Kumaresan, Akisik, Fatih

“…The purpose of this study was to determine if extracellular volume fraction and T1 mapping can be used to diagnose chronic pancreatitis (CP). This…”
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Characterization of 11C-GSK1482160 for Targeting the P2X7 Receptor as a Biomarker for Neuroinflammation by Territo, Paul R, Meyer, Jill A, Peters, Jonathan S, Riley, Amanda A, McCarthy, Brian P, Gao, Mingzhang, Wang, Min, Green, Mark A, Zheng, Qi-Huang, Hutchins, Gary D

“…The purinergic receptor subtype 7 (P2X7R) represents a novel molecular target for imaging neuroinflammation via PET. GSK1482160, a potent P2X7R antagonist, has…”
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18F-NaF and 18F-FDG as molecular probes in the evaluation of atherosclerosis by McKenney-Drake, Mikaela L., Moghbel, Mateen C., Paydary, Koosha, Alloosh, Mouhamad, Houshmand, Sina, Moe, Sharon, Salavati, Ali, Sturek, Jeffrey M., Territo, Paul R., Weaver, Connie, Werner, Thomas J., Høilund-Carlsen, Poul Flemming, Sturek, Michael, Alavi, Abass

“…The early detection of atherosclerotic disease is vital to the effective prevention and management of life-threatening cardiovascular events such as myocardial…”
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Cortical cerebrovascular and metabolic perturbations in the 5xFAD mouse model of Alzheimer's disease by Jullienne, Amandine, Szu, Jenny I, Quan, Ryan, Trinh, Michelle V, Norouzi, Tannoz, Noarbe, Brenda P, Bedwell, Amanda A, Eldridge, Kierra, Persohn, Scott C, Territo, Paul R, Obenaus, Andre

“…The 5xFAD mouse is a popular model of familial Alzheimer's disease (AD) that is characterized by early beta-amyloid (Aβ) deposition and cognitive decrements…”
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Beta Cell Imaging-From Pre-Clinical Validation to First in Man Testing by Demine, Stephane, Schulte, Michael L, Territo, Paul R, Eizirik, Decio L

“…There are presently no reliable ways to quantify human pancreatic beta cell mass (BCM) in vivo, which prevents an accurate understanding of the progressive…”
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Human Adipose‐Derived Stromal/Stem Cells Protect Against STZ‐Induced Hyperglycemia: Analysis of hASC‐Derived Paracrine Effectors by Kono, Tatsuyoshi M., Sims, Emily K., Moss, Dan R., Yamamoto, Wataru, Ahn, Geonyoung, Diamond, Julie, Tong, Xin, Day, Kathleen H., Territo, Paul R., Hanenberg, Helmut, Traktuev, Dmitry O., March, Keith L., Evans‐Molina, Carmella

“…Adipose‐derived stromal/stem cells (ASCs) ameliorate hyperglycemia in rodent models of islet transplantation and autoimmune diabetes, yet the precise human ASC…”
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Levetiracetam modulates brain metabolic networks and transcriptomic signatures in the 5XFAD mouse model of Alzheimer's disease by Burton, Charles P, Chumin, Evgeny J, Collins, Alyssa Y, Persohn, Scott A, Onos, Kristen D, Pandey, Ravi S, Quinney, Sara K, Territo, Paul R

“…Subcritical epileptiform activity is associated with impaired cognitive function and is commonly seen in patients with Alzheimer's disease (AD). The…”
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Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOEε4 and Trem2R47H by Kotredes, Kevin P, Oblak, Adrian, Pandey, Ravi S, Lin, Peter Bor-Chian, Garceau, Dylan, Williams, Harriet, Uyar, Asli, O'Rourke, Rita, O'Rourke, Sarah, Ingraham, Cynthia, Bednarycek, Daria, Belanger, Melisa, Cope, Zackary, Foley, Kate E, Logsdon, Benjamin A, Mangravite, Lara M, Sukoff Rizzo, Stacey J, Territo, Paul R, Carter, Gregory W, Sasner, Michael, Lamb, Bruce T, Howell, Gareth R

“…Late-onset Alzheimer's disease (AD; LOAD) is the most common human neurodegenerative disease, however, the availability and efficacy of disease-modifying…”
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Translational animal models for Alzheimer's disease: An Alzheimer's Association Business Consortium Think Tank by Vitek, Michael P., Araujo, Joseph A., Fossel, Michael, Greenberg, Barry D., Howell, Gareth R., Rizzo, Stacey J. Sukoff, Seyfried, Nicholas T., Tenner, Andrea J., Territo, Paul R., Windisch, Manfred, Bain, Lisa J., Ross, April, Carrillo, Maria C., Lamb, Bruce T., Edelmayer, Rebecca M.

“…Over 5 million Americans and 50 million individuals worldwide are living with Alzheimer's disease (AD). The progressive dementia associated with AD currently…”
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Model organism development and evaluation for late‐onset Alzheimer's disease: MODEL‐AD by Oblak, Adrian L., Forner, Stefania, Territo, Paul R., Sasner, Michael, Carter, Gregory W., Howell, Gareth R., Sukoff‐Rizzo, Stacey J., Logsdon, Benjamin A., Mangravite, Lara M., Mortazavi, Ali, Baglietto‐Vargas, David, Green, Kim N., MacGregor, Grant R., Wood, Marcelo A., Tenner, Andrea J., LaFerla, Frank M., Lamb, Bruce T.

“…Alzheimer's disease (AD) is a major cause of dementia, disability, and death in the elderly. Despite recent advances in our understanding of the basic…”
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A T Cell‐Engaging Tumor Organoid Platform for Pancreatic Cancer Immunotherapy by Zhou, Zhuolong, Van der Jeught, Kevin, Li, Yujing, Sharma, Samantha, Yu, Tao, Moulana, Ishara, Liu, Sheng, Wan, Jun, Territo, Paul R., Opyrchal, Mateusz, Zhang, Xinna, Wan, Guohui, Lu, Xiongbin

“…Pancreatic ductal adenocarcinoma (PDA) is a clinically challenging disease with limited treatment options. Despite a small percentage of cases with defective…”
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Chronic Embolic Pulmonary Hypertension Caused by Pulmonary Embolism and Vascular Endothelial Growth Factor Inhibition by Neto-Neves, Evandro M, Brown, Mary B, Zaretskaia, Maria V, Rezania, Samin, Goodwill, Adam G, McCarthy, Brian P, Persohn, Scott A, Territo, Paul R, Kline, Jeffrey A

“…Our understanding of the pathophysiological basis of chronic thromboembolic pulmonary hypertension (CTEPH) will be accelerated by an animal model that…”
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Synthesis and preliminary biological evaluation of radiolabeled 5-BDBD analogs as new candidate PET radioligands for P2X4 receptor by Wang, Min, Gao, Mingzhang, Meyer, Jill A., Peters, Jonathan S., Zarrinmayeh, Hamideh, Territo, Paul R., Hutchins, Gary D., Zheng, Qi-Huang

“…[Display omitted] P2X4 receptor has become an interesting molecular target for treatment and PET imaging of neuroinflammation and associated brain diseases…”
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Effects of renal sympathetic denervation on the stellate ganglion and brain stem in dogs by Tsai, Wei-Chung, MD, Chan, Yi-Hsin, MD, Chinda, Kroekkiat, DVM, PhD, Chen, Zhenhui, PhD, Patel, Jheel, BS, Shen, Changyu, PhD, Zhao, Ye, MD, Jiang, Zhaolei, MD, Yuan, Yuan, MD, Ye, Michael, BA, Chen, Lan S., MD, Riley, Amanda A., BA, Persohn, Scott A., BA, Territo, Paul R., PhD, Everett, Thomas H., IV, PhD, FACC, Lin, Shien-Fong, PhD, FACC, Vinters, Harry V., MD, Fishbein, Michael C., MD, Chen, Peng-Sheng, MD, FACC

“…Background Renal sympathetic denervation (RD) is a promising method of neuromodulation for the management of cardiac arrhythmia. Objective We tested the…”
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TRPV4 antagonists ameliorate ventriculomegaly in a rat model of hydrocephalus by Hochstetler, Alexandra E, Smith, Hillary M, Preston, Daniel C, Reed, Makenna M, Territo, Paul R, Shim, Joon W, Fulkerson, Daniel, Blazer-Yost, Bonnie L

“…Hydrocephalus is a serious condition that impacts patients of all ages. The standards of care are surgical options to divert, or inhibit production of,…”
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Multimodality imaging methods for assessing retinoblastoma orthotopic xenograft growth and development by Corson, Timothy W, Samuels, Brian C, Wenzel, Andrea A, Geary, Anna J, Riley, Amanda A, McCarthy, Brian P, Hanenberg, Helmut, Bailey, Barbara J, Rogers, Pamela I, Pollok, Karen E, Rajashekhar, Gangaraju, Territo, Paul R

“…Genomic studies of the pediatric ocular tumor retinoblastoma are paving the way for development of targeted therapies. Robust model systems such as orthotopic…”
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Novel application of complementary imaging techniques to examine in vivo glucose metabolism in the kidney by Hato, Takashi, Friedman, Allon N, Mang, Henry, Plotkin, Zoya, Dube, Shataakshi, Hutchins, Gary D, Territo, Paul R, McCarthy, Brian P, Riley, Amanda A, Pichumani, Kumar, Malloy, Craig R, Harris, Robert A, Dagher, Pierre C, Sutton, Timothy A

“…The metabolic status of the kidney is a determinant of injury susceptibility and a measure of progression for many disease processes; however, noninvasive…”
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Macrophage-derived LTB4 promotes abscess formation and clearance of Staphylococcus aureus skin infection in mice by Brandt, Stephanie L, Klopfenstein, Nathan, Wang, Soujuan, Winfree, Seth, McCarthy, Brian P, Territo, Paul R, Miller, Lloyd, Serezani, C Henrique

“…The early events that shape the innate immune response to restrain pathogens during skin infections remain elusive. Methicillin-resistant Staphylococcus aureus…”
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