Search Results - "Terreux, Raphaël"

Degradation of High Energy Materials Using Biological Reduction: A Rational Way to Reach Bioremediation by Aguero, Stephanie, Terreux, Raphaël

“…Explosives molecules have been widely used since World War II, leading to considerable contamination of soil and groundwater. Recently, bioremediation has…”
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Latent TGF-β Activation Is a Hallmark of the Tenascin Family by Aubert, Alexandre, Mercier-Gouy, Perrine, Aguero, Stéphanie, Berthier, Laurent, Liot, Sophie, Prigent, Laura, Alcaraz, Lindsay B., Verrier, Bernard, Terreux, Raphaël, Moali, Catherine, Lambert, Elise, Valcourt, Ulrich

“…Transforming growth factor-β (TGF-β) isoforms are secreted as inactive complexes formed through non-covalent interactions between bioactive TGF-β entities and…”
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Substituted Chromones as Highly Potent Nontoxic Inhibitors, Specific for the Breast Cancer Resistance Protein by Valdameri, Glaucio, Genoux-Bastide, Estelle, Peres, Basile, Gauthier, Charlotte, Guitton, Jérôme, Terreux, Raphaël, Winnischofer, Sheila M. B, Rocha, Maria E. M, Boumendjel, Ahcène, Di Pietro, Attilio

“…A series of 13 disubstituted chromones was synthesized. Two types of substituents, on each side of the scaffold, contributed to both the potency of ABCG2…”
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Pharmacogenomic screening identifies and repurposes leucovorin and dyclonine as pro-oligodendrogenic compounds in brain repair by Huré, Jean-Baptiste, Foucault, Louis, Ghayad, Litsa Maria, Marie, Corentine, Vachoud, Nicolas, Baudouin, Lucas, Azmani, Rihab, Ivjanin, Natalija, Arevalo-Nuevo, Alvaro, Pigache, Morgane, Bouslama-Oueghlani, Lamia, Chemelle, Julie-Anne, Dronne, Marie-Aimée, Terreux, Raphaël, Hassan, Bassem, Gueyffier, François, Raineteau, Olivier, Parras, Carlos

“…Oligodendrocytes are critical for CNS myelin formation and are involved in preterm-birth brain injury (PBI) and multiple sclerosis (MS), both of which lack…”
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Surface charge modulation of rifampicin-loaded PLA nanoparticles to improve antibiotic delivery in Staphylococcus aureus biofilms by Da Costa, David, Exbrayat-Héritier, Chloé, Rambaud, Basile, Megy, Simon, Terreux, Raphaël, Verrier, Bernard, Primard, Charlotte

“…After the golden age of antibiotic discovery, bacterial infections still represent a major challenge for public health worldwide. The biofilm mode of growth is…”
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In Silico, in Vitro, and in Vivo Evaluation of New Candidates for α‑Synuclein PET Imaging by Verdurand, Mathieu, Levigoureux, Elise, Zeinyeh, Wael, Berthier, Laurent, Mendjel-Herda, Meriem, Cadarossanesaib, Florence, Bouillot, Caroline, Iecker, Thibault, Terreux, Raphaël, Lancelot, Sophie, Chauveau, Fabien, Billard, Thierry, Zimmer, Luc

“…Accumulation of α-synuclein (α-syn) is a neuropathological hallmark of synucleinopathies. To date, no selective α-syn positron emission tomography (PET)…”
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Construction of atomic models of full hepatitis B vaccine particles at different stages of maturation by Berthier, Laurent, Brass, Olivier, Deleage, Gilbert, Terreux, Raphaël

“…Hepatitis B, one of the world’s most common liver infections, is caused by the Hepatitis B Virus (HBV). Via the infected cells, this virus generates non…”
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Daclatasvir-Like Inhibitors of NS5A Block Early Biogenesis of Hepatitis C Virus–Induced Membranous Replication Factories, Independent of RNA Replication by Berger, Carola, Romero-Brey, Inés, Radujkovic, Danijela, Terreux, Raphael, Zayas, Margarita, Paul, David, Harak, Christian, Hoppe, Simone, Gao, Min, Penin, Francois, Lohmann, Volker, Bartenschlager, Ralf

“…Background & Aims Direct-acting antivirals that target nonstructural protein 5A (NS5A), such as daclatasvir, have high potency against the hepatitis C virus…”
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Induction of a strong and long-lasting neutralizing immune response by dPreS1-TLR2 agonist nanovaccine against hepatitis B virus by Lamrayah, Myriam, Charriaud, Fanny, Desmares, Manon, Coiffier, Céline, Megy, Simon, Colomb, Evelyne, Terreux, Raphaël, Lucifora, Julie, Durantel, David, Verrier, Bernard

“…Hepatitis B virus remains a major medical burden with more than 250 million chronically infected patients worldwide and 900,000 deaths each year, due to the…”
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Casesidin-like anti-bacterial peptides in peptic hydrolysate of camel milk β-casein by Almi-Sebbane, Dalila, Adt, Isabelle, Degraeve, Pascal, Jardin, Julien, Bettler, Emmanuel, Terreux, Raphaël, Oulahal, Nadia, Mati, Abderahmane

“…The antibacterial activity of camel milk β-casein and its peptic hydrolysate was investigated. The hydrolysate was fractionated by ultrafiltration successively…”
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Investigation of Chalcones as Selective Inhibitors of the Breast Cancer Resistance Protein: Critical Role of Methoxylation in both Inhibition Potency and Cytotoxicity by Valdameri, Glaucio, Gauthier, Charlotte, Terreux, Raphaël, Kachadourian, Rémy, Day, Brian J, Winnischofer, Sheila M. B, Rocha, Maria E. M, Frachet, Véronique, Ronot, Xavier, Di Pietro, Attilio, Boumendjel, Ahcène

“…ABCG2 plays a major role in anticancer-drug efflux and related tumor multidrug resistance. Potent and selective ABCG2 inhibitors with low cytotoxicity were…”
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Bioinspired Design and Oriented Synthesis of Immunogenic Site-Specifically Penicilloylated Peptides by Scornet, Noémie, Delarue-Cochin, Sandrine, Azoury, Marie Eliane, Le Mignon, Maxime, Chemelle, Julie-Anne, Nony, Emmanuel, Maillère, Bernard, Terreux, Raphaël, Pallardy, Marc, Joseph, Delphine

“…β-Lactam antibiotics allergy is recognized as a public health concern. By covalently binding to serum proteins, penicillins are known to form immunogenic…”
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Uncompetitive nanomolar dimeric indenoindole inhibitors of the human breast cancer resistance pump ABCG2 by Guragossian, Nathalie, Belhani, Billel, Moreno, Alexis, Nunes, Magda Teixeira, Gonzalez-Lobato, Lucia, Marminon, Christelle, Berthier, Laurent, Rocio Andrade Pires, Amanda Do, Özvegy-Laczka, Csilla, Sarkadi, Balázs, Terreux, Raphaël, Bouaziz, Zouhair, Berredjem, Malika, Jose, Joachim, Di Pietro, Attilio, Falson, Pierre, Le Borgne, Marc

“…Multidrug resistance membrane pumps reduce the efficacy of chemotherapies by exporting a wide panel of structurally-divergent drugs. Here, to take advantage of…”
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In silico Genotoxicity Prediction by Similarity Search and Machine Learning Algorithm: Optimization and Validation of the Method for High Energetic Materials by Fournier, Mailys, Vroland, Christophe, Megy, Simon, Aguero, Stéphanie, Chemelle, Julie‐Anne, Defoort, Brigitte, Jacob, Guy, Terreux, Raphaël

“…The European regulation REACh (Registration, Evaluation, Authorization, and restriction of Chemicals) has placed responsibility on the industry to manage the…”
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Collateral sensitivity of resistant MRP1-overexpressing cells to flavonoids and derivatives through GSH efflux by Lorendeau, Doriane, Dury, Lauriane, Genoux-Bastide, Estelle, Lecerf-Schmidt, Florine, Simões-Pires, Claudia, Carrupt, Pierre-Alain, Terreux, Raphaël, Magnard, Sandrine, Di Pietro, Attilio, Boumendjel, Ahcène, Baubichon-Cortay, Hélène

“…The multidrug resistance protein 1 (MRP1) is involved in multidrug resistance of cancer cells by mediating drug efflux out of cells, often in co-transport with…”
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Identification of structural and molecular determinants of the tyrosine‐kinase Wzc and implications in capsular polysaccharide export by Bechet, Emmanuelle, Gruszczyk, Jakub, Terreux, Raphaël, Gueguen‐Chaignon, Virginie, Vigouroux, Armelle, Obadia, Brice, Cozzone, Alain J., Nessler, Sylvie, Grangeasse, Christophe

“…Summary Capsular polysaccharides are well‐established virulence factors of pathogenic bacteria. Their biosynthesis and export are regulated within the…”
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Bacterial tyrosine-kinases: Structure–function analysis and therapeutic potential by Grangeasse, Christophe, Terreux, Raphaël, Nessler, Sylvie

“…Since the characterization of genes encoding Ser/Thr-kinases and Tyr-kinases in bacteria, in 1991 and 1997, respectively, a growing body of evidence has been…”
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Active site coupling in Plasmodium falciparum GMP synthetase is triggered by domain rotation by Ballut, Lionel, Violot, Sébastien, Shivakumaraswamy, Santosh, Thota, Lakshmi Prasoona, Sathya, Manu, Kunala, Jyothirmai, Dijkstra, Bauke W., Terreux, Raphaël, Haser, Richard, Balaram, Hemalatha, Aghajari, Nushin

“…GMP synthetase (GMPS), a key enzyme in the purine biosynthetic pathway performs catalysis through a coordinated process across two catalytic pockets for which…”
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Delayed hypersensitivity to corticosteroids in a series of 315 patients: clinical data and patch test results by Baeck, Marie, Chemelle, Julie-Anne, Terreux, Raphaël, Drieghe, Jacques, Goossens, An

“…Background: Corticosteroids may cause immediate or delayed hypersensitivity. In 1989, based on structural and clinical characteristics, we put forward a…”
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Potent and Fully Noncompetitive Peptidomimetic Inhibitor of Multidrug Resistance P-Glycoprotein by Arnaud, Ophélie, Koubeissi, Ali, Ettouati, Laurent, Terreux, Raphaël, Alamé, Ghina, Grenot, Catherine, Dumontet, Charles, Di Pietro, Attilio, Paris, Joëlle, Falson, Pierre

“…N α-Boc-l-Asp(OBn)-l-Lys(Z)-OtBu (reversin 121, 1), an inhibitor of the P-gp ABC transporter, was used to conceive compounds inhibiting the drug efflux…”
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