Search Results - "Terrell, Tori B"

Characterization of passive permeability at the blood–tumor barrier in five preclinical models of brain metastases of breast cancer by Adkins, Chris E., Mohammad, Afroz S., Terrell-Hall, Tori B., Dolan, Emma L., Shah, Neal, Sechrest, Emily, Griffith, Jessica, Lockman, Paul R.

“…The blood–brain barrier (BBB) is compromised in brain metastases, allowing for enhanced drug permeation into brain. The extent and heterogeneity of BBB…”
Get full text

Paclitaxel-hyaluronic nanoconjugates prolong overall survival in a preclinical brain metastases of breast cancer model by Mittapalli, Rajendar K, Liu, Xinli, Adkins, Chris E, Nounou, Mohamed I, Bohn, Kaci A, Terrell, Tori B, Qhattal, Hussaini S, Geldenhuys, Werner J, Palmieri, Diane, Steeg, Patricia S, Smith, Quentin R, Lockman, Paul R

“…Brain (central nervous system; CNS) metastases pose a life-threatening problem for women with advanced metastatic breast cancer. It has recently been shown…”
Get full text

P-glycoprotein mediated efflux limits substrate and drug uptake in a preclinical brain metastases of breast cancer model by Adkins, Chris E, Mittapalli, Rajendar K, Manda, Vamshi K, Nounou, Mohamed I, Mohammad, Afroz S, Terrell, Tori B, Bohn, Kaci A, Yasemin, Celik, Grothe, Tiffany R, Lockman, Julie A, Lockman, Paul R

“…The blood-brain barrier (BBB) is a specialized vascular interface that restricts the entry of many compounds into brain. This is accomplished through the…”
Get full text

Liposomal Irinotecan Accumulates in Metastatic Lesions, Crosses the Blood-Tumor Barrier (BTB), and Prolongs Survival in an Experimental Model of Brain Metastases of Triple Negative Breast Cancer by Mohammad, Afroz S., Griffith, Jessica I., Adkins, Chris E., Shah, Neal, Sechrest, Emily, Dolan, Emma L., Terrell-Hall, Tori B., Hendriks, Bart S., Lee, Helen, Lockman, Paul R.

“…Purpose The blood-tumor barrier (BTB) limits irinotecan distribution in tumors of the central nervous system. However, given that the BTB has increased passive…”
Get full text

Trastuzumab distribution in an in-vivo and in-vitro model of brain metastases of breast cancer by Terrell-Hall, Tori B, Nounou, Mohamed Ismail, El-Amrawy, Fatema, Griffith, Jessica I G, Lockman, Paul R

“…Drug and antibody delivery to brain metastases has been highly debated in the literature. The blood-tumor barrier (BTB) is more permeable than the blood-brain…”
Get full text

Permeability across a novel microfluidic blood-tumor barrier model by Terrell-Hall, Tori B, Ammer, Amanda G, Griffith, Jessica I G, Lockman, Paul R

“…The lack of translatable in vitro blood-tumor barrier (BTB) models creates challenges in the development of drugs to treat tumors of the CNS and our…”
Get full text

Anti-cancer Antibody Trastuzumab-Melanotransferrin Conjugate (BT2111) for the Treatment of Metastatic HER2+ Breast Cancer Tumors in the Brain: an In-Vivo Study by Nounou, Mohamed Ismail, Adkins, Chris E., Rubinchik, Evelina, Terrell-Hall, Tori B., Afroz, Mohamed, Vitalis, Tim, Gabathuler, Reinhard, Tian, Mei Mei, Lockman, Paul R.

“…Purpose The ability of human melanotransferrin (hMTf) to carry a therapeutic concentration of trastuzumab (BTA) in the brain after conjugation (in the form of…”
Get full text

Semi-automated rapid quantification of brain vessel density utilizing fluorescent microscopy by Bohn, Kaci A., Adkins, Chris E., Mittapalli, Rajendar K., Terrell-Hall, Tori B., Mohammad, Afroz S., Shah, Neal, Dolan, Emma L., Nounou, Mohamed I., Lockman, Paul R.

“…[Display omitted] Vascular density varies significantly between brain regions and between healthy and diseased tissue. However, current methods are arduous and…”
Get full text

Abstract 2080: Demonstration of casual relationship between blood-tumor barrier permeability changes and chemotherapeutic uptake and effect in brain micrometastases of breast cancer by Mohammad, Afroz Shareef, Adkins, Chris E., Dolan, Emma L., Terrell-Hall, Tori B., Lockman, Paul R.

“…Background: 10-16% of women with advanced breast cancer will develop symptomatic brain metastases, the survival rate of which is less than 2 years. When…”
Get full text

A novel preclinical method to quantitatively evaluate early-stage metastatic events at the murine blood-brain barrier by Adkins, Chris E, Nounou, Mohamed I, Mittapalli, Rajendar K, Terrell-Hall, Tori B, Mohammad, Afroz S, Jagannathan, Rajaganapathi, Lockman, Paul R

“…The observation that approximately 15% of women with disseminated breast cancer will develop symptomatic brain metastases combined with treatment guidelines…”
Get full text

Abstract 4592: Etirinotecan pegol accumulates in breast cancer brain metastases and prolongs survival in an experimental model of brain metastases of human triple negative breast cancer by Nounou, Mohamed, Hoch, Ute, Adkins, Chris E., Terrell, Tori B., Villalba, Heidi, Eldon, Michael E., Lockman, Paul R.

“…Background: Breast cancer brain metastases (BCBM) remain a challenging consequence of advanced breast cancer. The blood-brain barrier prevents many…”
Get full text

Paclitaxel-Hyaluronic Nano-Conjugates Prolong Overall Survival in a Preclinical Brain Metastases of Breast Cancer Model by Mittapalli, Rajendar K., Liu, Xinli, Adkins, Chris E., Nounou, Mohamed I., Bohn, Kaci A., Terrell, Tori B., Qhattal, Hussaini S., Geldenhuys, Werner J., Palmieri, Diane, Steeg, Patricia S., Smith, Quentin R., Lockman, Paul R.

“…Brain (CNS) metastases pose a life-threatening problem for women with advanced metastatic breast cancer. It has recently been shown that the vasculature within…”
Get full text

Abstract 4528: Characterization of changes in passive permeability and drug uptake at the blood-tumor barrier in four preclinical models of brain metastases of breast cancer by Mohammad, Afroz Shareef, Adkins, Chris E., Mittapalli, Rajendar K., Terrell-Hall, Tori B., Nounou, Mohamed Ismail, Lockman, Paul R.

“…Background: Brain metastasis of breast cancer remain a challenging consequence of advanced breast cancer. To effectively treat brain metastases with anticancer…”
Get full text

Abstract 1388: Inhibition of VEGF and angiopoietin-2 to reduce brain metastases of breast cancer burden by Bohn, Kaci A., Sechrest, Emily R., Adkins, Chris E., Mittapalli, Rajendar K., Nounou, Mohamed I., Terrell-Hall, Tori B., Mohammad, Afroz S., Lockman, Paul R.

“…Introduction: In cancer, vascular destabilization and angiogenesis enhance tumor growth, metastatic potential, and correlate with poor patient outcome. A…”
Get full text

Abstract 5207: Vascular remodeling is associated with increased permeability of experimental brain metastases of breast cancer by Bohn, Kaci A., Terrell-Hall, Tori B., Adkins, Chris E., Mittapalli, Rajendar K., Nounou, Mohamed I., Mohammad, Afroz S., Lockman, Paul R.

“…Approximately 1 in 8 women will develop breast cancer. Of these women, a subset develop metastatic breast cancer, of which 10-16% develop brain metastases…”
Get full text