Search Results - "Terrar, Derek A"

Modernized Classification of Cardiac Antiarrhythmic Drugs by Lei, Ming, Wu, Lin, Terrar, Derek A, Huang, Christopher L.-H

“…BACKGROUND:Among his major cardiac electrophysiological contributions, Miles Vaughan Williams (1918–2016) provided a classification of antiarrhythmic drugs…”
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Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current If : Novel electrophysiological insights and therapeutic potential by Capel, Rebecca A., DPhil, Herring, Neil, DPhil, MRCP, Kalla, Manish, BSc (Hons), MBBS MRCP, Yavari, Arash, BSc (Hons), MBBS, MRCP, DPhil, Mirams, Gary R., PhD, Douglas, Gillian, PhD, Bub, Gil, PhD, Channon, Keith, MD, FRCP, FMedSci, Paterson, David J., DPhil, DSc, Terrar, Derek A., PhD, Burton, Rebecca-Ann B., MSc, MBA, DPhil

“…Background Bradycardic agents are of interest for the treatment of ischemic heart disease and heart failure, as heart rate is an important determinant of…”
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Transverse cardiac slicing and optical imaging for analysis of transmural gradients in membrane potential and Ca2+ transients in murine heart by Wen, Q., Gandhi, K., Capel, Rebecca A., Hao, G., O'Shea, C., Neagu, G., Pearcey, S., Pavlovic, D., Terrar, Derek A., Wu, J., Faggian, G., Camelliti, Patrizia, Lei, M.

“…Key points A robust cardiac slicing approach was developed for optical mapping of transmural gradients in transmembrane potential (Vm) and intracellular Ca2+…”
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Terrar Opinion supplement by Terrar, Derek A.

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Calcium flux balance across cell membranes in the heart: important unanswered questions with implications for the role of ryanodine receptors by Terrar, Derek A.

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Inhibition of adenylyl cyclase 1 by ST034307 inhibits IP3-evoked changes in sino-atrial node beat rate by Bose, Samuel J., Read, Matthew J., Akerman, Emily, Capel, Rebecca A., Ayagama, Thamali, Russell, Angela, Terrar, Derek A., Zaccolo, Manuela, Burton, Rebecca A. B.

“…Atrial arrhythmias, such as atrial fibrillation (AF), are a major mortality risk and a leading cause of stroke. The IP 3 signalling pathway has been proposed…”
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Timing mechanisms to control heart rhythm and initiate arrhythmias: roles for intracellular organelles, signalling pathways and subsarcolemmal Ca2 by Terrar, Derek A

“…Rhythms of electrical activity in all regions of the heart can be influenced by a variety of intracellular membrane bound organelles. This is true both for…”
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Ca2+‐stimulated adenylyl cyclases regulate the L‐type Ca2+ current in guinea‐pig atrial myocytes by Collins, Thomas P., Terrar, Derek A.

“…Key points  •  Adenylyl cyclases (ACs), the enzymes that synthesize cAMP, are essential for the inotropic response of cardiac muscle to adrenergic stimulation…”
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Timing mechanisms to control heart rhythm and initiate arrhythmias: roles for intracellular organelles, signalling pathways and subsarcolemmal Ca 2 by Terrar, Derek A

“…Rhythms of electrical activity in all regions of the heart can be influenced by a variety of intracellular membrane bound organelles. This is true both for…”
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Inhibition of angiotensin II-induced cardiac hypertrophy and associated ventricular arrhythmias by a p21 activated kinase 1 bioactive peptide by Wang, Rui, Wang, Yanwen, Lin, Wee K, Zhang, Yanmin, Liu, Wei, Huang, Kai, Terrar, Derek A, Solaro, R John, Wang, Xin, Ke, Yunbo, Lei, Ming

“…Cardiac hypertrophy increases the risk of morbidity and mortality of cardiovascular disease and thus inhibiting such hypertrophy is beneficial. In the present…”
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Endolysosomal calcium release and cardiac physiology by Terrar, Derek A

“…•Small acidic vesicles can act as an intracellular source of Ca2+ in cardiac muscle.•These vesicles are termed endolysosomes and are elliptical…”
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Pnmt-Derived Cardiomyocytes: Anatomical Localization, Function and Future Perspectives by Fan, Xuehui, Sun, Tianyi, Crawford, William, Tan, Xiaoqiu, Ou, Xianhong, Terrar, Derek A, Ebert, Steven N, Lei, Ming

“…In this mini-review, we provide an overview of phenylethanolamine-N-methyl transferase (Pnmt)-derived cardiomyocytes (PdCMs), a recently discovered…”
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NAADP Controls Cross-talk between Distinct Ca2+ Stores in the Heart by Macgregor, Andrew, Yamasaki, Michiko, Rakovic, Stevan, Sanders, Luke, Parkesh, Raman, Churchill, Grant C., Galione, Antony, Terrar, Derek A.

“…In cardiac muscle the sarcoplasmic reticulum (SR) plays a key role in the control of contraction, releasing Ca2+ in response to Ca2+ influx across the…”
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Cardiac Neuronal Nitric Oxide Synthase Isoform Regulates Myocardial Contraction and Calcium Handling by Sears, Claire E, Bryant, Simon M, Ashley, Euan A, Lygate, Craig A, Rakovic, Stevan, Wallis, Helen L, Neubauer, Stefan, Terrar, Derek A, Casadei, B

“…ABSTRACT—A neuronal isoform of nitric oxide synthase (nNOS) has recently been located to the cardiac sarcoplasmic reticulum (SR). Subcellular localization of a…”
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Fundamental importance of Na+–Ca2+ exchange for the pacemaking mechanism in guinea-pig sino-atrial node by Sanders, Luke, Rakovic, Stevan, Lowe, Matthew, Mattick, Paul A. D., Terrar, Derek A.

“…Na + –Ca 2+ exchange (NCX) current has been suggested to play a role in cardiac pacemaking, particularly in association with Ca 2+ release from the…”
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Generation of cardiomyocytes from human-induced pluripotent stem cells resembling atrial cells with ability to respond to adrenoceptor agonists by Ahmad, Faizzan S, Jin, Yongcheng, Grassam-Rowe, Alexander, Zhou, Yafei, Yuan, Meng, Fan, Xuehui, Zhou, Rui, Mu-U-Min, Razik, O'Shea, Christopher, Ibrahim, Ayman M, Hyder, Wajiha, Aguib, Yasmine, Yacoub, Magdi, Pavlovic, Davor, Zhang, Yanmin, Tan, Xiaoqiu, Lei, Ming, Terrar, Derek A

“…Atrial fibrillation (AF) is the most common chronic arrhythmia presenting a heavy disease burden. We report a new approach for generating cardiomyocytes (CMs)…”
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Synthesis of the Ca2+-mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in β-adrenoceptor signaling by Lin, Wee K., Bolton, Emma L., Cortopassi, Wilian A., Wang, Yanwen, O'Brien, Fiona, Maciejewska, Matylda, Jacobson, Matthew P., Garnham, Clive, Ruas, Margarida, Parrington, John, Lei, Ming, Sitsapesan, Rebecca, Galione, Antony, Terrar, Derek A.

“…Nicotinic acid adenine dinucleotide phosphate (NAADP) and cyclic ADP-ribose (cADPR) are Ca2+-mobilizing messengers important for modulating cardiac…”
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Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Signaling in the Heart by Capel, Rebecca A., Bolton, Emma L., Lin, Wee K., Aston, Daniel, Wang, Yanwen, Liu, Wei, Wang, Xin, Burton, Rebecca-Ann B., Bloor-Young, Duncan, Shade, Kai-Ting, Ruas, Margarida, Parrington, John, Churchill, Grant C., Lei, Ming, Galione, Antony, Terrar, Derek A.

“…Ca2+-permeable type 2 two-pore channels (TPC2) are lysosomal proteins required for nicotinic acid adenine dinucleotide phosphate (NAADP)-evoked Ca2+ release in…”
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High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart by Aston, Daniel, Capel, Rebecca A., Ford, Kerrie L., Christian, Helen C., Mirams, Gary R., Rog-Zielinska, Eva A., Kohl, Peter, Galione, Antony, Burton, Rebecca A. B., Terrar, Derek A.

“…Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) stimulates calcium release from acidic stores such as lysosomes and is a highly potent calcium-mobilising…”
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The importance of Ca(2+)-dependent mechanisms for the initiation of the heartbeat by Capel, Rebecca A, Terrar, Derek A

“…Mechanisms underlying pacemaker activity in the sinus node remain controversial, with some ascribing a dominant role to timing events in the surface membrane…”
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