Search Results - "Terranova, Marc A"

Central mechanisms regulating penile erection in conscious rats: the dopaminergic systems related to the proerectile effect of apomorphine by Hsieh, Gin C, Hollingsworth, Peter R, Martino, Brenda, Chang, Renjie, Terranova, Marc A, O'Neill, Alyssa B, Lynch, James J, Moreland, Robert B, Donnelly-Roberts, Diana L, Kolasa, Teodozyi, Mikusa, Joseph P, McVey, Jill M, Marsh, Kennan C, Sullivan, James P, Brioni, Jorge D

“…Apomorphine has been used as a pharmacological probe of dopaminergic receptors in a variety of central nervous system disorders. The utility of apomorphine as…”
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Synthesis and functional activity of (2-aryl-1-piperazinyl)-N-(3-methylphenyl)acetamides: selective dopamine D4 receptor agonists by Matulenko, Mark A, Hakeem, Ahmed A, Kolasa, Teodozyi, Nakane, Masaki, Terranova, Marc A, Uchic, Marie E, Miller, Loan N, Chang, Renjie, Donnelly-Roberts, Diana L, Namovic, Marian T, Moreland, Robert B, Brioni, Jorge D, Stewart, Andrew O

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Discovery of 3-Methyl-N-(1-oxy-3‘,4‘,5‘,6‘-tetrahydro-2‘H-[2,4‘-bipyridine]-1‘-ylmethyl)benzamide (ABT-670), an Orally Bioavailable Dopamine D4 Agonist for the Treatment of Erectile Dysfunction by Patel, Meena V, Kolasa, Teodozyj, Mortell, Kathleen, Matulenko, Mark A, Hakeem, Ahmed A, Rohde, Jeffrey J, Nelson, Sherry L, Cowart, Marlon D, Nakane, Masaki, Miller, Loan N, Uchic, Marie E, Terranova, Marc A, El-Kouhen, Odile F, Donnelly-Roberts, Diana L, Namovic, Marian T, Hollingsworth, Peter R, Chang, Renjie, Martino, Brenda R, Wetter, Jill M, Marsh, Kennan C, Martin, Ruth, Darbyshire, John F, Gintant, Gary, Hsieh, Gin C, Moreland, Robert B, Sullivan, James P, Brioni, Jorge D, Stewart, Andrew O

“…The goal of this study was to identify a structurally distinct D4-selective agonist with superior oral bioavailability to our first-generation clinical…”
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Discovery of 2-(4-Pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a Dopaminergic Agent with a Novel Mode of Action for the Potential Treatment of Erectile Dysfunction by Cowart, Marlon, Latshaw, Steven P, Bhatia, Pramila, Daanen, Jerome F, Rohde, Jeffrey, Nelson, Sherry L, Patel, Meena, Kolasa, Teodozyi, Nakane, Masaki, Uchic, Marie E, Miller, Loan N, Terranova, Marc A, Chang, Renjie, Donnelly-Roberts, Diana L, Namovic, Marian T, Hollingsworth, Peter R, Martino, Brenda R, Lynch, James J, Sullivan, James P, Hsieh, Gin C, Moreland, Robert B, Brioni, Jorge D, Stewart, Andrew O

“…A new class of agents with potential utility for the treatment of erectile dysfunction has been discovered, guided by the hypothesis that selective D4 agonists…”
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Comparative pharmacology of human dopamine D2-like receptor stable cell lines coupled to calcium flux through Gαqo5 by MORELAND, Robert B, NAKANE, Masaki, EL-KOUHEN, Odile F, MASTERS, Jeffrey N, BRIONI, Jorge D, DONNELLY-ROBERTS, Diana L, MILLER, Loan N, CHANG, Renjie, UCHIC, Marie E, TERRANOVA, Marc A, GUBBINS, Earl J, HELFRICH, Rosalind J, NAMOVIC, Marian T

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1-Aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one Oximes as Potent Dopamine D4 Receptor Agonists for the Treatment of Erectile Dysfunction by Kolasa, Teodozyj, Matulenko, Mark A, Hakeem, Ahmed A, Patel, Meena V, Mortell, Kathleen, Bhatia, Pramila, Henry, Rodger, Nakane, Masaki, Hsieh, Gin C, Terranova, Marc A, Uchic, Marie E, Miller, Loan N, Chang, Renje, Donnelly-Roberts, Diana L, Namovic, Marian T, Hollingsworth, Peter R, Martino, Brenda, El Kouhen, Odile, Marsh, Kennan C, Wetter, Jill M, Moreland, Robert B, Brioni, Jorge D, Stewart, Andrew O

“…A new series of dopamine D4 receptor agonists, 1-aryl-3-(4-pyridinepiperazin-1-yl)propanone oximes, was designed through the modification of known dopamine D4…”
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Dopamine D4 Ligands and Models of Receptor Activation:  2-(4-Pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and Related Heteroarylmethylarylpiperazines Exhibit a Substituent Effect Responsible for Additional Efficacy Tuning by Stewart, Andrew O, Cowart, Marlon D, Moreland, Robert B, Latshaw, Steve P, Matulenko, Mark A, Bhatia, Pramila A, Wang, Xueqing, Daanen, Jerome F, Nelson, Sherry L, Terranova, Marc A, Namovic, Marian T, Donnelly-Roberts, Diana L, Miller, Loan N, Nakane, Masaki, Sullivan, James P, Brioni, Jorge D

“…A series of subtype selective dopamine D4 receptor ligands from the hetroarylmethylphenylpiperazine class have been discovered that exhibit a remarkable…”
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2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist by Nakane, Masaki, Cowart, Marlon D, Hsieh, Gin C, Miller, Loan, Uchic, Marie E, Chang, Renjie, Terranova, Marc A, Donnelly-Roberts, Diana L, Namovic, Marian T, Miller, Thomas R, Wetter, Jill M, Marsh, Kennan, Stewart, Andrew O, Brioni, Jorge D, Moreland, Robert B

“…2-[4-(3,4-Dimethylphenlyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393) was identified as a potent dopamine D4 receptor antagonist with excellent receptor…”
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3H] A-369508 ([2-[4-(2-cyanophenyl)-1-piperazinyl]-N-(3-methylphenyl) acetamide): an agonist radioligand selective for the dopamine D4 receptor by MORELAND, Robert B, TERRANOVA, Marc A, CHANG, Renjie, UCHIC, Marie E, MATULENKO, Mark A, SURBER, Bruce W, STEWART, Andrew O, BRIONI, Jorge D

“…Tritiation of the dopamine D(4) receptor selective agonist A-369508 ([2-[4-(2-cyanophenyl)-1-piperazinyl]-N-(3-methylphenyl) acetamide) has provided a…”
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Synthesis and activity of 2-[4-(4-[3H]-2-cyanophenyl)piperazinyl]-N-(2,4,6-[3H]3-3-methylphenyl)acetamide: a selective dopamine D4 receptor agonist and radioligand by Matulenko, Mark A., Surber, Bruce, Fan, Leimin, Kolasa, Teodozyi, Nakane, Masaki, Terranova, Marc A., Uchic, Marie E., Miller, Loan N., Chang, Renjie, Donnelly-Roberts, Diana L., Namovic, Marian T., Moreland, Robert B., Brioni, Jorge D., Stewart, Andrew O.

“…[Display omitted] The first selective dopamine D4 agonist radioligand is described. The synthesis of these piperazine radioligands relied on the transformation…”
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Discovery of 3-Methyl- N -(1-oxy-3‘,4‘,5‘,6‘-tetrahydro-2‘ H -[2,4‘-bipyridine]-1‘-ylmethyl)benzamide (ABT-670), an Orally Bioavailable Dopamine D 4 Agonist for the Treatment of Erectile Dysfunction by Patel, Meena V., Kolasa, Teodozyj, Mortell, Kathleen, Matulenko, Mark A., Hakeem, Ahmed A., Rohde, Jeffrey J., Nelson, Sherry L., Cowart, Marlon D., Nakane, Masaki, Miller, Loan N., Uchic, Marie E., Terranova, Marc A., El-Kouhen, Odile F., Donnelly-Roberts, Diana L., Namovic, Marian T., Hollingsworth, Peter R., Chang, Renjie, Martino, Brenda R., Wetter, Jill M., Marsh, Kennan C., Martin, Ruth, Darbyshire, John F., Gintant, Gary, Hsieh, Gin C., Moreland, Robert B., Sullivan, James P., Brioni, Jorge D., Stewart, Andrew O.

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1-Aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one Oximes as Potent Dopamine D 4 Receptor Agonists for the Treatment of Erectile Dysfunction by Kolasa, Teodozyj, Matulenko, Mark A., Hakeem, Ahmed A., Patel, Meena V., Mortell, Kathleen, Bhatia, Pramila, Henry, Rodger, Nakane, Masaki, Hsieh, Gin C., Terranova, Marc A., Uchic, Marie E., Miller, Loan N., Chang, Renje, Donnelly-Roberts, Diana L., Namovic, Marian T., Hollingsworth, Peter R., Martino, Brenda, El Kouhen, Odile, Marsh, Kennan C., Wetter, Jill M., Moreland, Robert B., Brioni, Jorge D., Stewart, Andrew O.

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Synthesis and functional activity of (2-aryl-1-piperazinyl)- N-(3-methylphenyl)acetamides: selective dopamine D 4 receptor agonists by Matulenko, Mark A, Hakeem, Ahmed A, Kolasa, Teodozyi, Nakane, Masaki, Terranova, Marc A, Uchic, Marie E, Miller, Loan N, Chang, Renjie, Donnelly-Roberts, Diana L, Namovic, Marian T, Moreland, Robert B, Brioni, Jorge D, Stewart, Andrew O

“…Graphic Diaryl piperazine acetamides were identified as potent and selective dopamine D 4 receptor agonists. Our strategy is based on an amide bond reversal of…”
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2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D 4 receptor antagonist by Nakane, Masaki, Cowart, Marlon D., Hsieh, Gin C., Miller, Loan, Uchic, Marie E., Chang, Renjie, Terranova, Marc A., Donnelly-Roberts, Diana L., Namovic, Marian T., Miller, Thomas R., Wetter, Jill M., Marsh, Kennan, Stewart, Andrew O., Brioni, Jorge D., Moreland, Robert B.

“…2-[4-(3,4-Dimethylphenlyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393) was identified as a potent dopamine D 4 receptor antagonist with excellent…”
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3 H] A-369508 ([2-[4-(2-cyanophenyl)-1-piperazinyl]- N-(3-methylphenyl) acetamide): an agonist radioligand selective for the dopamine D 4 receptor by Moreland, Robert B., Terranova, Marc A., Chang, Renjie, Uchic, Marie E., Matulenko, Mark A., Surber, Bruce W., Stewart, Andrew O., Brioni, Jorge D.

“…Tritiation of the dopamine D 4 receptor selective agonist A-369508 ([2-[4-(2-cyanophenyl)-1-piperazinyl]- N-(3-methylphenyl) acetamide) has provided a…”
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Comparative pharmacology of human dopamine D(2)-like receptor stable cell lines coupled to calcium flux through Galpha(qo5) by Moreland, Robert B, Nakane, Masaki, Donnelly-Roberts, Diana L, Miller, Loan N, Chang, Renjie, Uchic, Marie E, Terranova, Marc A, Gubbins, Earl J, Helfrich, Rosalind J, Namovic, Marian T, El-Kouhen, Odile F, Masters, Jeffrey N, Brioni, Jorge D

“…The goal of this study was to develop a new approach to study the pharmacology of the dopamine D(4) receptor that could be used in comparative studies with…”
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Synthesis and functional activity of (2-aryl-1-piperazinyl)-N-(3-methylphenyl)acetamides: selective dopamine D4 receptor agonists by MATULENKO, Mark A, HAKEEM, Ahmed A, MORELAND, Robert B, BRIONI, Jorge D, STEWART, Andrew O, KOLASA, Teodozyi, NAKANE, Masaki, TERRANOVA, Marc A, UCHIC, Marie E, MILLER, Loan N, CHANG, Renjie, DONNELLY-ROBERTS, Diana L, NAMOVIC, Marian T

“…Diaryl piperazine acetamides were identified as potent and selective dopamine D(4) receptor agonists. Our strategy is based on an amide bond reversal of an…”
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Comparative pharmacology of human dopamine D 2-like receptor stable cell lines coupled to calcium flux through Gα qo5 by Moreland, Robert B, Nakane, Masaki, Donnelly-Roberts, Diana L, Miller, Loan N, Chang, Renjie, Uchic, Marie E, Terranova, Marc A, Gubbins, Earl J, Helfrich, Rosalind J, Namovic, Marian T, El-Kouhen, Odile F, Masters, Jeffrey N, Brioni, Jorge D

“…The goal of this study was to develop a new approach to study the pharmacology of the dopamine D 4 receptor that could be used in comparative studies with…”
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Discovery of 2-(4-Pyridin-2-ylpiperazin-1-ylmethyl)-1 H -benzimidazole (ABT-724), a Dopaminergic Agent with a Novel Mode of Action for the Potential Treatment of Erectile Dysfunction by Cowart, Marlon, Latshaw, Steven P., Bhatia, Pramila, Daanen, Jerome F., Rohde, Jeffrey, Nelson, Sherry L., Patel, Meena, Kolasa, Teodozyi, Nakane, Masaki, Uchic, Marie E., Miller, Loan N., Terranova, Marc A., Chang, Renjie, Donnelly-Roberts, Diana L., Namovic, Marian T., Hollingsworth, Peter R., Martino, Brenda R., Lynch, James J., Sullivan, James P., Hsieh, Gin C., Moreland, Robert B., Brioni, Jorge D., Stewart, Andrew O.

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Dopamine D 4 Ligands and Models of Receptor Activation:  2-(4-Pyridin-2-ylpiperazin-1-ylmethyl)-1 H -benzimidazole and Related Heteroarylmethylarylpiperazines Exhibit a Substituent Effect Responsible for Additional Efficacy Tuning by Stewart, Andrew O., Cowart, Marlon D., Moreland, Robert B., Latshaw, Steve P., Matulenko, Mark A., Bhatia, Pramila A., Wang, Xueqing, Daanen, Jerome F., Nelson, Sherry L., Terranova, Marc A., Namovic, Marian T., Donnelly-Roberts, Diana L., Miller, Loan N., Nakane, Masaki, Sullivan, James P., Brioni, Jorge D.

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