Search Results - "Terracciano, Luigi M."

The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size by Planas-Paz, Lara, Orsini, Vanessa, Boulter, Luke, Calabrese, Diego, Pikiolek, Monika, Nigsch, Florian, Xie, Yang, Roma, Guglielmo, Donovan, Adriana, Marti, Patricia, Beckmann, Nicolau, Dill, Michael T., Carbone, Walter, Bergling, Sebastian, Isken, Andrea, Mueller, Matthias, Kinzel, Bernd, Yang, Yi, Mao, Xiaohong, Nicholson, Thomas B., Zamponi, Raffaella, Capodieci, Paola, Valdez, Reginald, Rivera, Daniel, Loew, Andreas, Ukomadu, Chinweike, Terracciano, Luigi M., Bouwmeester, Tewis, Cong, Feng, Heim, Markus H., Forbes, Stuart J., Ruffner, Heinz, Tchorz, Jan S.

“…LGR4/5 receptors and their cognate RSPO ligands potentiate Wnt/β-catenin signalling and promote proliferation and tissue homeostasis in epithelial stem cell…”
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Integrative proteogenomic characterization of hepatocellular carcinoma across etiologies and stages by Ng, Charlotte K. Y., Dazert, Eva, Boldanova, Tuyana, Coto-Llerena, Mairene, Nuciforo, Sandro, Ercan, Caner, Suslov, Aleksei, Meier, Marie-Anne, Bock, Thomas, Schmidt, Alexander, Ketterer, Sylvia, Wang, Xueya, Wieland, Stefan, Matter, Matthias S., Colombi, Marco, Piscuoglio, Salvatore, Terracciano, Luigi M., Hall, Michael N., Heim, Markus H.

“…Proteogenomic analyses of hepatocellular carcinomas (HCC) have focused on early-stage, HBV-associated HCCs. Here we present an integrated proteogenomic…”
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YAP promotes proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma through TEAD transcription factors by Marti, Patricia, Stein, Claudia, Blumer, Tanja, Abraham, Yann, Dill, Michael T., Pikiolek, Monika, Orsini, Vanessa, Jurisic, Giorgia, Megel, Philippe, Makowska, Zuzanna, Agarinis, Claudia, Tornillo, Luigi, Bouwmeester, Tewis, Ruffner, Heinz, Bauer, Andreas, Parker, Christian N., Schmelzle, Tobias, Terracciano, Luigi M., Heim, Markus H., Tchorz, Jan S.

“…The Yes‐associated protein (YAP)/Hippo pathway has been implicated in tissue development, regeneration, and tumorigenesis. However, its role in…”
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Identifying and Targeting ROS1 Gene Fusions in Non―Small Cell Lung Cancer by DAVIES, Kurtis D, LE, Anh T, ALLOISIO, Marco, SANTORO, Armando, ROSS CAMIDGE, D, VARELLA-GARCIA, Marileila, DOEBELE, Robert C, THEODORO, Mariana F, SKOKAN, Margaret C, AISNER, Dara L, BERGE, Eamon M, TERRACCIANO, Luigi M, CAPPUZZO, Federico, INCARBONE, Matteo, RONCALLI, Massimo

“…Oncogenic gene fusions involving the 3' region of ROS1 kinase have been identified in various human cancers. In this study, we sought to characterize ROS1…”
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The Role of Long Non-Coding RNAs in Hepatocarcinogenesis by Lanzafame, Manuela, Bianco, Gaia, Terracciano, Luigi M, Ng, Charlotte K Y, Piscuoglio, Salvatore

“…Whole-transcriptome analyses have revealed that a large proportion of the human genome is transcribed in non-protein-coding transcripts, designated as long…”
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Enhanced expression of ANO1 in head and neck squamous cell carcinoma causes cell migration and correlates with poor prognosis by Ruiz, Christian, Martins, Joana Raquel, Rudin, Florian, Schneider, Sandra, Dietsche, Tanja, Fischer, Claude A, Tornillo, Luigi, Terracciano, Luigi M, Schreiber, Rainer, Bubendorf, Lukas, Kunzelmann, Karl

“…Head and neck squamous cell carcinoma (HNSCC) has the potential for early metastasis and is associated with poor survival. Ano1 (Dog1) is an established and…”
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Variable asialoglycoprotein receptor 1 expression in liver disease: Implications for therapeutic intervention by Witzigmann, Dominik, Quagliata, Luca, Schenk, Susanne H., Quintavalle, Cristina, Terracciano, Luigi M., Huwyler, Jörg

“…Aim One of the most promising strategies for the treatment of liver diseases is targeted drug delivery via the asialoglycoprotein receptor (ASGPR). The success…”
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LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function by Tang, Fengyuan, Gao, Ruize, Jeevan-Raj, Beena, Wyss, Christof B., Kalathur, Ravi K. R., Piscuoglio, Salvatore, Ng, Charlotte K. Y., Hindupur, Sravanth K., Nuciforo, Sandro, Dazert, Eva, Bock, Thomas, Song, Shuang, Buechel, David, Morini, Marco F., Hergovich, Alexander, Matthias, Patrick, Lim, Dae-Sik, Terracciano, Luigi M., Heim, Markus H., Hall, Michael N., Christofori, Gerhard

“…Autophagy perturbation represents an emerging therapeutic strategy in cancer. Although LATS1 and LATS2 kinases, core components of the mammalian Hippo pathway,…”
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Intratumoral budding as a potential parameter of tumor progression in mismatch repair–proficient and mismatch repair–deficient colorectal cancer patients by Lugli, Alessandro, MD, Vlajnic, Tatjana, MD, Giger, Olivier, MD, Karamitopoulou, Eva, Patsouris, Efstratios S., MD, Peros, George, MD, Terracciano, Luigi M., MD, Zlobec, Inti, PhD

“…Summary In colorectal cancer, tumor budding at the invasive front (peritumoral budding) is an established prognostic parameter and decreased in mismatch…”
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Systematic identification of novel cancer genes through analysis of deep shRNA perturbation screens by Montazeri, Hesam, Coto-Llerena, Mairene, Bianco, Gaia, Zangene, Ehsan, Taha-Mehlitz, Stephanie, Paradiso, Viola, Srivatsa, Sumana, de Weck, Antoine, Roma, Guglielmo, Lanzafame, Manuela, Bolli, Martin, Beerenwinkel, Niko, von Flüe, Markus, Terracciano, Luigi M, Piscuoglio, Salvatore, Ng, Charlotte K Y

“…Abstract Systematic perturbation screens provide comprehensive resources for the elucidation of cancer driver genes. The perturbation of many genes in…”
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Prevention of dsRNA‐induced interferon signaling by AGO1x is linked to breast cancer cell proliferation by Ghosh, Souvik, Guimaraes, Joao C, Lanzafame, Manuela, Schmidt, Alexander, Syed, Afzal Pasha, Dimitriades, Beatrice, Börsch, Anastasiya, Ghosh, Shreemoyee, Mittal, Nitish, Montavon, Thomas, Correia, Ana Luisa, Danner, Johannes, Meister, Gunter, Terracciano, Luigi M, Pfeffer, Sébastien, Piscuoglio, Salvatore, Zavolan, Mihaela

“…Translational readthrough, i.e., elongation of polypeptide chains beyond the stop codon, was initially reported for viral RNA, but later found also on…”
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High Expression of FAP in Colorectal Cancer Is Associated With Angiogenesis and Immunoregulation Processes by Coto-Llerena, Mairene, Ercan, Caner, Kancherla, Venkatesh, Taha-Mehlitz, Stephanie, Eppenberger-Castori, Serenella, Soysal, Savas D, Ng, Charlotte K Y, Bolli, Martin, von Flüe, Markus, Nicolas, Guillaume P, Terracciano, Luigi M, Fani, Melpomeni, Piscuoglio, Salvatore

“…Fibroblast activation protein α (FAP) plays an important role in tissue remodeling and helps tumor cells invade surrounding tissue. We sought to investigate…”
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Is the improved prognosis of p16 positive oropharyngeal squamous cell carcinoma dependent of the treatment modality? by Fischer, Claude A., Zlobec, Inti, Green, Edith, Probst, Simone, Storck, Claudio, Lugli, Alessandro, Tornillo, Luigi, Wolfensberger, Markus, Terracciano, Luigi M.

“…The incidence of human papilloma virus (HPV) induced oropharyngeal squamous cell carcinoma (OPSCC) increases in the western countries. These OPSCC show…”
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Cell adhesion molecule KIRREL1 is a feedback regulator of Hippo signaling recruiting SAV1 to cell-cell contact sites by Paul, Atanu, Annunziato, Stefano, Lu, Bo, Sun, Tianliang, Evrova, Olivera, Planas-Paz, Lara, Orsini, Vanessa, Terracciano, Luigi M., Charlat, Olga, Loureiro, Zinger Yang, Ji, Lei, Zamponi, Raffaella, Sigoillot, Frederic, Lei, Hong, Lindeman, Alicia, Russ, Carsten, Reece-Hoyes, John S., Nicholson, Thomas B., Tchorz, Jan S., Cong, Feng

“…The Hippo/YAP pathway controls cell proliferation through sensing physical and spatial organization of cells. How cell-cell contact is sensed by Hippo…”
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Multi-omics data integration reveals novel drug targets in hepatocellular carcinoma by Dimitrakopoulos, Christos, Hindupur, Sravanth Kumar, Colombi, Marco, Liko, Dritan, Ng, Charlotte K. Y, Piscuoglio, Salvatore, Behr, Jonas, Moore, Ariane L, Singer, Jochen, Ruscheweyh, Hans-Joachim, Matter, Matthias S, Mossmann, Dirk, Terracciano, Luigi M, Hall, Michael N, Beerenwinkel, Niko

“…Abstract Background Genetic aberrations in hepatocellular carcinoma (HCC) are well known, but the functional consequences of such aberrations remain poorly…”
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Ribociclib-induced liver injury: a case report by Schaeffer, Sofia, Lutz, Christian, Dobbie, Michael, Terracciano, Luigi M, Matter, Matthias, Vosbeck, Jürg, Heim, Markus H, Bernsmeier, Christine

“…Idiosyncratic drug-induced liver injury (DILI) is a rare, unpredictable hepatic adverse event and the most common cause of acute liver failure in Europe and…”
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Prospective Validation of the ROL System in Substaging pT1 High-Grade Urothelial Carcinoma: Results from a Mono-Institutional Confirmatory Analysis in BCG Treated Patients by Valeri, Marina, Contieri, Roberto, Fasulo, Vittorio, Iuzzolino, Martina, Cieri, Miriam, Elefante, Grazia M, De Carlo, Camilla, Bressan, Alessandra, Saitta, Cesare, Gobbo, Andrea, Avolio, Pier Paolo, Dacrema, Valerio, Lazzeri, Massimo, Taverna, Gianluigi, Terracciano, Luigi M, Hurle, Rodolfo, Colombo, Piergiuseppe

“…Patients with pT1 high-grade (HG) urothelial carcinoma (UC) and a very high risk of progression might benefit from immediate radical cystectomy (RC), but this…”
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TMEM123 a key player in immune surveillance of colorectal cancer by Pesce, Elisa, Cordiglieri, Chiara, Bombaci, Mauro, Eppenberger-Castori, Serenella, Oliveto, Stefania, Manara, Cristina, Crosti, Mariacristina, Ercan, Caner, Coto, Mairene, Gobbini, Andrea, Campagnoli, Susanna, Donnarumma, Tiziano, Martinelli, Manuele, Bevilacqua, Valeria, De Camilli, Elisa, Gruarin, Paola, Sarnicola, Maria L, Cassinotti, Elisa, Baldari, Ludovica, Viale, Giuseppe, Biffo, Stefano, Abrignani, Sergio, Terracciano, Luigi M, Grifantini, Renata

“…Colorectal cancer (CRC) is a leading cause of cancer-associated death. In the tumor site, the interplay between effector immune cells and cancer cells…”
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Corrigendum: TMEM123 a key player in immune surveillance of colorectal cancer by Pesce, Elisa, Cordiglieri, Chiara, Bombaci, Mauro, Eppenberger-Castori, Serenella, Oliveto, Stefania, Manara, Cristina, Crosti, Mariacristina, Ercan, Caner, Coto, Mairene, Gobbini, Andrea, Campagnoli, Susanna, Donnarumma, Tiziano, Martinelli, Manuele, Bevilacqua, Valeria, De Camilli, Elisa, Gruarin, Paola, Sarnicola, Maria L, Cassinotti, Elisa, Baldari, Ludovica, Viale, Giuseppe, Biffo, Stefano, Abrignani, Sergio, Terracciano, Luigi M, Grifantini, Renata

“…[This corrects the article DOI: 10.3389/fimmu.2023.1194087.]…”
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Liver damage and senescence increases in patients developing hepatocellular carcinoma by Rey, Silvia, Quintavalle, Cristina, Burmeister, Katharina, Calabrese, Diego, Schlageter, Manuel, Quagliata, Luca, Cathomas, Gieri, Diebold, Joachim, Molinolo, Alfredo, Heim, Markus H, Terracciano, Luigi M, Matter, Matthias S

“…Background and Aim Most patients with a hepatocellular carcinoma (HCC) have an underlying chronic liver inflammation, which causes a continuous damage leading…”
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