Search Results - "Terracciano, Cesare M.N."

Action Potential Morphology of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Does Not Predict Cardiac Chamber Specificity and Is Dependent on Cell Density by Du, David T.M., Hellen, Nicola, Kane, Christopher, Terracciano, Cesare M.N.

“…Previous studies investigating human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have proposed the distinction of heart chamber-specific…”
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Genetic variation in SCN10A influences cardiac conduction by Chambers, John C, Kooner, Jaspal S, Zhao, Jing, Terracciano, Cesare M N, Bezzina, Connie R, Zhang, Weihua, Kaba, Riyaz, Navaratnarajah, Manoraj, Lotlikar, Amol, Sehmi, Joban S, Kooner, Manraj K, Deng, Guohong, Siedlecka, Urszula, Parasramka, Saurabh, El-Hamamsy, Ismail, Wass, Mark N, Dekker, Lukas R C, de Jong, Jonas S S G, Sternberg, Michael J E, McKenna, William, Severs, Nicholas J, de Silva, Ranil, Wilde, Arthur A M, Anand, Praveen, Yacoub, Magdi, Scott, James, Elliott, Paul, Wood, John N

“…To identify genetic factors influencing cardiac conduction, we carried out a genome-wide association study of electrocardiographic time intervals in 6,543…”
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Direct intramyocardial but not intracoronary injection of bone marrow cells induces ventricular arrhythmias in a rat chronic ischemic heart failure model by FUKUSHIMA, Satsuki, VARELA-CARVER, Anabel, COPPEN, Steven R, YAMAHARA, Kenichi, FELKIN, Leanne E, LEE, Joon, BARTON, Paul J. R, TERRACCIANO, Cesare M. N, YACOUB, Magdi H, SUZUKI, Ken

“…Therapeutic efficacy of bone marrow (BM) cell injection for treating ischemic chronic heart failure has not been established. In addition, experimental data…”
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Phosphoregulation of the titin-cap protein telethonin in cardiac myocytes by Candasamy, Alexandra J, Haworth, Robert S, Cuello, Friederike, Ibrahim, Michael, Aravamudhan, Sriram, Krüger, Marcus, Holt, Mark R, Terracciano, Cesare M N, Mayr, Manuel, Gautel, Mathias, Avkiran, Metin

“…Telethonin (also known as titin-cap or t-cap) is a muscle-specific protein whose mutation is associated with cardiac and skeletal myopathies through unknown…”
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Prolonged mechanical unloading affects cardiomyocyte excitation-contraction coupling, transverse-tubule structure, and the cell surface by Ibrahim, Michael, Al Masri, Abeer, Navaratnarajah, Manoraj, Siedlecka, Urszula, Soppa, Gopal K, Moshkov, Alexey, Al-Saud, Sara Abou, Gorelik, Julia, Yacoub, Magdi H, Terracciano, Cesare M.N

“…Prolonged mechanical unloading (UN) of the heart is associated with detrimental changes to the structure and function of cardiomyocytes. The mechanisms…”
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Direct effects of apelin on cardiomyocyte contractility and electrophysiology by Farkasfalvi, Klára, Stagg, Mark A., Coppen, Steven R., Siedlecka, Urszula, Lee, Joon, Soppa, Gopal K., Marczin, Nándor, Szokodi, István, Yacoub, Magdi H., Terracciano, Cesare M.N.

“…Apelin, the ligand for the angiotensin receptor like-1, has been implicated in the pathogenesis of atrial fibrillation and heart failure. However, it is…”
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Donor cell-type specific paracrine effects of cell transplantation for post-infarction heart failure by Shintani, Yasunori, Fukushima, Satsuki, Varela-Carver, Anabel, Lee, Joon, Coppen, Steven R, Takahashi, Kunihiko, Brouilette, Scott W, Yashiro, Kenta, Terracciano, Cesare M.N, Yacoub, Magdi H, Suzuki, Ken

“…Abstract Cell transplantation is an emerging therapy for treating post-infarction heart failure. Although the paracrine effect has been proposed to be an…”
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Cytoskeletal Protein 4.1R Affects Repolarization and Regulates Calcium Handling in the Heart by Stagg, Mark A, Carter, Edward, Sohrabi, Nadia, Siedlecka, Urszula, Soppa, Gopal K, Mead, Fiona, Mohandas, Narla, Taylor-Harris, Pamela, Baines, Anthony, Bennett, Pauline, Yacoub, Magdi H, Pinder, Jennifer C, Terracciano, Cesare M.N

“…The 4.1 proteins are a family of multifunctional adaptor proteins. They promote the mechanical stability of plasma membranes by interaction with the…”
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Prolonged Mechanical Unloading Reduces Myofilament Sensitivity to Calcium and Sarcoplasmic Reticulum Calcium Uptake Leading to Contractile Dysfunction by Soppa, Gopal K.R., MRCS, Lee, Joon, MRCS, Stagg, Mark A., PhD, Siedlecka, Urszula, PhD, Youssef, Samuel, MBBS, Yacoub, Magdi H., FRS, Terracciano, Cesare M.N., MD, PhD

“…Background Prolonged unloading using left ventricular (LV) assist devices (LVADs) leads to unloading-induced atrophy with altered cardiomyocyte contractility…”
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Changes in sarcolemmal Ca entry and sarcoplasmic reticulum Ca content in ventricular myocytes from patients with end-stage heart failure following myocardial recovery after combined pharmacological and ventricular assist device therapy by Terracciano, Cesare M.N, Harding, Sian E, Adamson, Dawn, Koban, Maren, Tansley, Patrick, Birks, Emma J, Barton, Paul J.R, Yacoub, Magdi H

“…Aims Support with left ventricular assist devices (LVAD) improves cardiac performance in patients with end-stage heart failure. In some cases this strategy,…”
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Functional and morphological maturation of implanted neonatal cardiomyocytes as a comparator for cell therapy by Sato, Motoki, Carr, Carolyn A, Stuckey, Daniel J, Ishii, Hikaru, Kanda, Gaelle Kikonda, Terracciano, Cesare M N, Siedlecka, Urszula, Tatton, Louise, Watt, Suzanne M, Martin-Rendon, Enca, Clarke, Kieran, Harding, Sian E

“…Knowledge of the rate of development of immature cardiomyocytes after implantation into a host heart is important for studies using cell therapy. To assess…”
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SERCA2a Overexpression Decreases the Incidence of Aftercontractions in Adult Rabbit Ventricular Myocytes by Davia, Kerry, Bernobich, Elena, Ranu, Hardeep K., del Monte, Federica, Terracciano, Cesare M.N., MacLeod, Kenneth T., Adamson, Dawn L., Chaudhri, Babar, Hajjar, Roger J., Harding, Sian E.

“…K. Davia, E. Bernobich, H. K. Ranu, F. del Monte, C. M. N. Terracciano, K. T. MacLeod, D. L. Adamson, B. Chaudhri, R. J. Hajjar and S. E. Harding. SERCA2a…”
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Response to Letter Regarding Article, “Direct Intramyocardial but Not Intracoronary Injection of Bone Marrow Cells Induces Ventricular Arrhythmias in a Rat Chronic Ischemic Heart Failure Model” by Suzuki, Ken, Fukushima, Satsuki, Varela-Carver, Anabel, Coppen, Steven R., Yamahara, Kenichi, Felkin, Leanne E., Lee, Joon, Barton, Paul J.R., Terracciano, Cesare M.N., Yacoub, Magdi H.

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Concise Review: Criteria for Chamber‐Specific Categorization of Human Cardiac Myocytes Derived from Pluripotent Stem Cells by Kane, Christopher, Terracciano, Cesare M. N.

“…Human pluripotent stem cell‐derived cardiomyocytes (PSC‐CMs) have great potential application in almost all areas of cardiovascular research. A current major…”
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Sarcoplasmic reticulum calcium release function and FK binding proteins in heart failure: another piece of a complex jigsaw by Terracciano, Cesare M.N

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Corrigendum to “Donor cell-type specific paracrine effects of cell transplantation for post-infarction heart failure” [J Mol Cell Cardiol 47 (2009) 288–295] by Shintani, Yasunori, Fukushima, Satsuki, Varela-Carver, Anabel, Lee, Joon, Coppen, Steven R., Takahashi, Kunihiko, Brouilette, Scott W., Yashiro, Kenta, Terracciano, Cesare M.N., Yacoub, Magdi H., Suzuki, Ken

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Many Cells Make Life Work-Multicellularity in Stem Cell-Based Cardiac Disease Modelling by Wang, Brian X, Kit-Anan, Worrapong, Terracciano, Cesare M N

“…Cardiac disease causes 33% of deaths worldwide but our knowledge of disease progression is still very limited. In vitro models utilising and combining…”
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Translational Cardiology: defining limits and targets at the International Archives of Medicine

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Excitation-contraction coupling of human induced pluripotent stem cell-derived cardiomyocytes by Kane, Christopher, Couch, Liam, Terracciano, Cesare M N

“…Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) hold enormous potential in many fields of cardiovascular research. Overcoming many of the…”
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Phosphoregulation of the Titin-cap Protein Telethonin in Cardiac MyocytesThis work was supported by British Heart Foundation (BHF) 4-year Ph.D. Program FS/06/079, Centre of Research Excellence Award RE/08/003, and Medical Research Council Grant G0800206.▪▪This article contains supplemental Figs. S1–S5, Experimental Procedures, and references by Candasamy, Alexandra J., Haworth, Robert S., Cuello, Friederike, Ibrahim, Michael, Aravamudhan, Sriram, Krüger, Marcus, Holt, Mark R., Terracciano, Cesare M.N., Mayr, Manuel, Gautel, Mathias, Avkiran, Metin

“…Telethonin (also known as titin-cap or t-cap) is a muscle-specific protein whose mutation is associated with cardiac and skeletal myopathies through unknown…”
Get full text