CD146+ bone marrow osteoprogenitors increase in the advanced stages of primary myelofibrosis

1 Department of Human Pathology, Paolo Giaccone University Hospital, University of Palermo, Palermo 2 Pathology Unit, Department of Medicine, Surgery and Odontology, San Paolo Hospital, and "Policlinico IRCCS" Hospital, Mangiagalli and Regina Elena Foundation, University of Milan 3 Departm...

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Published in:	Haematologica (Roma) Vol. 94; no. 1; pp. 127 - 130
Main Authors:	Tripodo, Claudio, Di Bernardo, Andrea, Ternullo, Maria Paola, Guarnotta, Carla, Porcasi, Rossana, Ingrao, Sabrina, Gianelli, Umberto, Boveri, Emanuela, Iannitto, Emilio, Franco, Giovanni, Florena, Ada Maria
Format:	Journal Article
Language:	English
Published:	Pavia Ferrata Storti Foundation 01-01-2009
Subjects:	Adult Aged Aged, 80 and over Biological and medical sciences Bone Marrow Cells - cytology Bone Marrow Cells - metabolism Brief Reports CD146 Antigen - metabolism Cell Proliferation Female Hematologic and hematopoietic diseases Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged Neoplasm Staging Primary Myelofibrosis - metabolism Primary Myelofibrosis - pathology Stem Cells - cytology Stem Cells - metabolism Myeloproliferative syndrome Myelofibrosis Hematology primary myelofibrosis Bone marrow Advanced stage bone marrow osteoprogenitors Hemopathy
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Summary:	1 Department of Human Pathology, Paolo Giaccone University Hospital, University of Palermo, Palermo 2 Pathology Unit, Department of Medicine, Surgery and Odontology, San Paolo Hospital, and "Policlinico IRCCS" Hospital, Mangiagalli and Regina Elena Foundation, University of Milan 3 Department of Surgical Pathology, University of Pavia Medical School, IRCCS Policlinico San Matteo Foundation, Pavia 4 Haematology Unit, Department of Oncology and Haematology, Paolo Giaccone University Hospital, University of Palermo, Italy Correspondence: Claudio Tripodo, MD, Department of Human Pathology, University of Palermo, via del Vespro 129, 90127, Palermo, Italy. E-mail: tripodo{at}unipa.it CD146 + bone marrow stromal cells have been recently recognized as clonogenic osteoprogenitors able to organize a complete hematopoietic microenvironment. In this study we used immunohistochemical analysis to investigate the contribution of CD146 + bone marrow osteoprogenitors to the stromal remodeling occurring in the different stages of primary myelofibrosis. We found that CD146 + cells sited at the abluminal side of the bone marrow vessels and branching among hematopoietic cells significantly increased in the advanced stages of primary myelofibrosis ( p <0.001), paralleling the extent of fibrosis ( =0.916, p <0.0001) and the microvascular density (r=0.883, p <0.0001). Coherently with a mural cell function, such cells also displayed smooth-muscle actin expression. Our data providing evidence of CD146 + cell involvement in bone marrow stromal changes occurring in primary myelofibrosis are consistent with the capability of these cells to participate in fiber deposition, angiogenesis, and bone formation. They could also represent rationale for new therapies targeting the bone marrow stroma in primary myelofibrosis. Key words: bone marrow osteoprogenitors, primary myelofibrosis.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0390-6078 1592-8721
DOI:	10.3324/haematol.13598