Search Results - "Terman, GW"

Mu Opiates Inhibit Long-Term Potentiation Induction in the Spinal Cord Slice by Terman, Gregory W, Eastman, Clifford L, Chavkin, Charles

“…  1 Department of Anesthesiology,   2 Department of Pharmacology, and the Graduate Program in Neurobiology and Behavior, University of Washington School of…”
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Postoperative Opioid-induced Respiratory Depression: A Closed Claims Analysis by Lee, Lorri A, Caplan, Robert A, Stephens, Linda S, Posner, Karen L, Terman, Gregory W, Voepel-Lewis, Terri, Domino, Karen B

“…BACKGROUND:Postoperative opioid-induced respiratory depression (RD) is a significant cause of death and brain damage in the perioperative period. The authors…”
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Transition to chronic pain: opportunities for novel therapeutics by Price, Theodore J., Basbaum, Allan I., Bresnahan, Jacqueline, Chambers, Jan F., De Koninck, Yves, Edwards, Robert R., Ji, Ru-Rong, Katz, Joel, Kavelaars, Annemieke, Levine, Jon D., Porter, Linda, Schechter, Neil, Sluka, Kathleen A., Terman, Gregory W., Wager, Tor D., Yaksh, Tony L., Dworkin, Robert H.

“…Although chronic pain is one of the most important medical problems facing society, there has been very limited progress in the development of novel therapies…”
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Kappa opioids inhibit induction of long-term potentiation in the dentate gyrus of the guinea pig hippocampus by Terman, GW, Wagner, JJ, Chavkin, C

“…NMDA receptor-mediated long-term potentiation (LTP) of dentate granule cell responses to perforant path stimulation was inhibited by the kappa 1 opioid…”
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Ultra-Low Dose Ketamine and Memantine Treatment for Pain in an Opioid-Tolerant Oncology Patient by Grande, Lucinda A., O’Donnell, Brendan R., Fitzgibbon, Dermot R., Terman, Gregory W.

“…Patients taking high-dose opioids chronically for tumor-related or neuropathic pain may develop pain that is refractory to opioids. One option for control of…”
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Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance by Xu, Mei, Petraschka, Michael, McLaughlin, Jay P, Westenbroek, Ruth E, Caron, Marc G, Lefkowitz, Robert J, Czyzyk, Traci A, Pintar, John E, Terman, Gregory W, Chavkin, Charles

“…Release of endogenous dynorphin opioids within the spinal cord after partial sciatic nerve ligation (pSNL) is known to contribute to the neuropathic pain…”
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G‐protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal by Terman, Gregory W, Jin, Wenzhen, Cheong, Young‐Pyo, Lowe, Janet, Caron, Marc G, Lefkowitz, Robert J, Chavkin, Charles

“…Tolerance to opioids frequently follows repeated drug administration and affects the clinical utility of these analgesics. Studies in simple cellular systems…”
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A case of opiate-insensitive pain: malignant treatment of benign pain by Terman, G W, Loeser, J D

“…We report the case of a woman with presumed cancer pain treated with escalating doses of opiates despite no evident improvement in her pain and several…”
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Endogenous dynorphins inhibit excitatory neurotransmission and block LTP induction in the hippocampus by Wagner, John J, Terman, Gregory W, Chavkin, Charles

“…Although anatomical and neurochemical studies suggest that endogenous opioids act as neurotransmitters, their roles in normal and pathophysiological regulation…”
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APS position statement on the use of placebos in pain management by Sullivan, Mark, Terman, Gregory W, Peck, Brian, Correll, Darin J, Rich, Ben, Clark, W Crawford, Latta, Kenneth, Lebovits, Allen, Gebhart, Gerald

“…In the spring of 2003, the board of directors of the American Pain Society asked the APS Ethics Committee to formulate a position statement for the Society…”
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TrkB Activation by Brain-derived Neurotrophic Factor Inhibits the G Protein-gated Inward Rectifier Kir3 by Tyrosine Phosphorylation of the Channel by Rogalski, Sherri L., Appleyard, Suzanne M., Pattillo, Aaron, Terman, Gregory W., Chavkin, Charles

“…G protein-activated inwardly rectifying potassium channels (Kir3) are widely expressed throughout the brain, and regulation of their activity modifies neuronal…”
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Opioid Modulation of Recurrent Excitation in the Hippocampal Dentate Gyrus by Terman, Gregory W, Drake, Carrie T, Simmons, Michele L, Milner, Teresa A, Chavkin, Charles

“…kappa opioid receptor activation inhibits granule cell-mediated excitatory neurotransmission in the hippocampal formation via a decrease in glutamate release…”
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Dynorphin opioids present in dentate granule cells may function as retrograde inhibitory neurotransmitters by Drake, CT, Terman, GW, Simmons, ML, Milner, TA, Kunkel, DD, Schwartzkroin, PA, Chavkin, C

“…The granule cell population response to perforant path stimulation decreased significantly within seconds following release of endogenous dynorphin from…”
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L-type calcium channels mediate dynorphin neuropeptide release from dendrites but not axons of hippocampal granule cells by Simmons, Michele L, Terman, Gregory W, Gibbs, Sarah M, Chavkin, Charles

“…Granule cells in the guinea pig dentate gyrus release κ opioid neuropeptides, dynorphins, from dendrites as well as from axon terminals. We have found that…”
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Stress, opioid peptides, the immune system, and cancer by Shavit, Y, Terman, GW, Martin, FC, Lewis, JW, Liebeskind, JC, Gale, RP

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Administered and endogenously released kappa opioids decrease pilocarpine-induced seizures and seizure-induced histopathology by Bausch, S B, Esteb, T M, Terman, G W, Chavkin, C

“…The effects of kappa opioids on seizures and seizure-induced histopathology were investigated with the pilocarpine model of temporal lobe epilepsy. Rats…”
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Spontaneous Excitatory Currents and kappa -Opioid Receptor Inhibition in Dentate Gyrus Are Increased in the Rat Pilocarpine Model of Temporal Lobe Epilepsy by Simmons, Michele L, Terman, Gregory W, Chavkin, Charles

“…Michele L. Simmons 1 , Gregory W. Terman 2 , and Charles Chavkin 1 1  Department of Pharmacology and 2  Department of Anesthesiology, University of Washington,…”
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A multidimensional comparison of morphine and hydromorphone patient-controlled analgesia by RAPP, S. E, EGAN, K. J, ROSS, B. K, WILD, L. M, TERMAN, G. W, CHING, J. M

“…Although patient-controlled analgesia (PCA) pumps have been in use for more than a decade, the optimal PCA analgesic has yet to be identified. Many drugs are…”
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John C. Liebeskind (1935-1997): A Tribute by Terman, Gregory W.

“…Neurologist and researcher John C. Liebeskind died Sept. 8, 1997, at home with his family. Liebeskind, who was elected to the National Academy of Sciences in…”
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Intrinsic Mechanisms of Pain Inhibition: Activation by Stress by Terman, Gregory W., Shavit, Yehuda, Lewis, James W., Cannon, J. Timothy, Liebeskind, John C.

“…Portions of the brain stem seem normally to inhibit pain. In man and laboratory animals these brain areas and pathways from them to spinal sensory circuits can…”
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