Search Results - "Terman, B I"

Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization by DOUGHER, M, TERMAN, B. I

“…We have previously reported the identification of four autophosphorylation sites on the KDR VEGF receptor. Two of these sites (tyrosines 951 and 996) are…”
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The related FLT4, FLT1, and KDR receptor tyrosine kinases show distinct expression patterns in human fetal endothelial cells by KAIPAINEN, A, KORHONEN, J, PAJUSOLA, K, APRELIKOVA, O, PERSICO, M. G, TERMAN, B. I, ALITALO, K

“…The growth factor receptors expressed on endothelial cells are of special interest because of their potential to program endothelial cell growth and…”
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Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor by Terman, B I, Dougher-Vermazen, M, Carrion, M E, Dimitrov, D, Armellino, D C, Gospodarowicz, D, Böhlen, P

“…Vascular endothelial cell growth factor (VEGF), also known as vascular permeability factor, is an endothelial cell mitogen which stimulates angiogenesis. Here…”
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Vascular Endothelial Growth Factor-Induced Migration of Vascular Smooth Muscle Cells in Vitro by Grosskreutz, Cynthia L., Anand-Apte, Bela, Dupláa, Cécile, Quinn, Timothy P., Terman, Bruce I., Zetter, Bruce, D'Amore, Patricia A.

“…Angiogenesis is a complex process that includes recruitment and proliferation of mural cells—smooth muscle cells (SMC) and pericytes. Vascular endothelial…”
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Biological activity and phosphorylation sites of the bacterially expressed cytosolic domain of the KDR VEGF-receptor by Dougher-Vermazen, M, Hulmes, J D, Böhlen, P, Terman, B I

“…Vascular endothelial growth factor (VEGF) is a potent angiogenic factor which binds to two structurally similar receptor tyrosine kinases, KDR and FLT1…”
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Expression of the vascular endothelial growth factor receptor, KDR, in human placenta by Vuckovic, M, Ponting, J, Terman, B I, Niketic, V, Seif, M W, Kumar, S

“…Vascular endothelial growth factor (VEGF) is a heparin-binding growth factor known to act directly on vascular endothelial cells by promoting cell…”
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TEM8 expression stimulates endothelial cell adhesion and migration by regulating cell–matrix interactions on collagen by Hotchkiss, Kylie A., Basile, Cheryl M., Spring, Simone C., Bonuccelli, Gloria, Lisanti, Michael P., Terman, Bruce I.

“…The TEM8 gene is selectively expressed in tumor versus normal blood vessels, though its function in endothelial cell biology is not known. Towards the goal of…”
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Angiogenesis activators and inhibitors differentially regulate caveolin-1 expression and caveolae formation in vascular endothelial cells. Angiogenesis inhibitors block vascular endothelial growth factor-induced down-regulation of caveolin-1 by Liu, J, Razani, B, Tang, S, Terman, B I, Ware, J A, Lisanti, M P

“…Angiogenesis is the process by which new blood vessels are formed via proliferation of vascular endothelial cells. A variety of angiogenesis inhibitors that…”
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Identification of a new endothelial cell growth factor receptor tyrosine kinase by Terman, B I, Carrion, M E, Kovacs, E, Rasmussen, B A, Eddy, R L, Shows, T B

“…A new growth factor receptor tyrosine kinase (RTK) gene (designated KDR) has been cloned from a human endothelial cell cDNA library. The gene was identified…”
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Kinase Insert Domain Receptor (KDR) Extracellular Immunoglobulin-like Domains 4–7 Contain Structural Features That Block Receptor Dimerization and Vascular Endothelial Growth Factor-induced Signaling by Tao, Qi, Backer, Marina V., Backer, Joseph M., Terman, Bruce I.

“…The vascular endothelial growth factor (VEGF) receptor tyrosine kinase subtype kinase insert domain receptor (KDR) contains seven extracellular Ig-like…”
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Identification and structural characterization of alpha 1-adrenergic receptor subtypes by Terman, B I, Riek, R P, Grodski, A, Hess, H J, Graham, R M

“…Rat liver and brain membrane alpha 1-adrenergic receptors were purified greater than 500-fold by successive chromatographic steps using heparin-agarose, an…”
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NCK and PAK Participate in the Signaling Pathway by Which Vascular Endothelial Growth Factor Stimulates the Assembly of Focal Adhesions by Stoletov, Konstantin V., Ratcliffe, Kirsty E., Spring, Simone C., Terman, Bruce I.

“…Vascular endothelial growth factor (VEGF)-induced endothelial cell migration is a key step in the angiogenic response and is mediated, in part, by an…”
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Alpha 1-adrenergic receptor-linked guanine nucleotide-binding protein in muscle and kidney epithelial cells by Terman, B I, Slivka, S R, Hughes, R J, Insel, P A

“…We have studied the interaction of guanine nucleotides with alpha 1-adrenergic receptors of two cloned cell lines, the Madin Darby canine kidney (MDCK-D1)…”
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The kinase insert domain receptor gene (KDR) has been relocated to chromosome 4q11-->q12 by Sait, S N, Dougher-Vermazen, M, Shows, T B, Terman, B I

“…Through in situ hybridization of a genomic DNA probe to metaphase chromosomes, we have localized the KDR gene to 4q11-->q12. This is the same locus as that for…”
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Photoaffinity labeling of alpha 1-adrenergic receptors of rat heart by Terman, B I, Insel, P A

“…The photoaffinity probe [125I]aryl azidoprazosin was used to examine structural aspects of rat left ventricular alpha 1-adrenergic receptor. Autoradiography of…”
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Bmx is a downstream Rap1 effector in VEGF-induced endothelial cell activation by Stoletov, Konstantin V, Terman, Bruce I

“…We had previously shown that Rap1 mediates certain of the signaling pathways involved in VEGF-induced endothelial cell migration, although the downstream Rap1…”
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Biological properties of VEGF/VPF receptors by Terman, B I, Dougher-Vermazen, M

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Use of 1-deoxymannojirimycin to show that complex oligosaccharides regulate cellular distribution of the alpha 1-adrenergic receptor glycoprotein in BC3H1 muscle cells by Terman, B I, Insel, P A

“…We have previously shown that alpha 1-adrenergic receptors in BC3H1 muscle cells are glycoproteins containing complex but not high mannose oligosaccharides. In…”
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The KDR gene maps to human chromosome 4q31.2----q32, a locus which is distinct from locations for other type III growth factor receptor tyrosine kinases by Terman, B I, Jani-Sait, S, Carrion, M E, Shows, T B

“…KDR (kinase insert domain receptor), a new type III receptor tyrosine kinase gene, maps to human chromosome 4q31.2---q32 by fluorescence in situ hybridization…”
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Sck is expressed in endothelial cells and participates in vascular endothelial growth factor-induced signaling by RATCLIFFE, Kirsty E, QI TAO, YAVUZ, Burju, STOLETOV, Konstantin V, SPRING, Simone C, TERMAN, Bruce I

“…Sck, a member of the Shc family of cell signaling proteins, has only been studied in neuronal cells, though previous studies have demonstrated its expression…”
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