Search Results - "Terencio, José"
-
1
Systems biology and artificial intelligence analysis highlights the pleiotropic effect of IVIg therapy in autoimmune diseases with a predominant role on B cells and complement system
Published in Frontiers in immunology (30-09-2022)“…Intravenous immunoglobulin (IVIg) is used as treatment for several autoimmune and inflammatory conditions, but its specific mechanisms are not fully…”
Get full text
Journal Article -
2
Novel Multipotent Tacrine−Dihydropyridine Hybrids with Improved Acetylcholinesterase Inhibitory and Neuroprotective Activities as Potential Drugs for the Treatment of Alzheimer's Disease
Published in Journal of medicinal chemistry (28-12-2006)“…In this work we describe the synthesis and biological evaluation of the tacrine−1,4-dihydropyridine (DHP) hybrids (3−11). These multipotent molecules are the…”
Get full text
Journal Article -
3
Retroperitoneal white adipose tissue lipoprotein lipase activity is rapidly down-regulated in response to acute stress
Published in Journal of lipid research (01-04-2007)“…Tissue-specific regulation of LPL has been widely studied in rats. Previous studies reported that in vivo administration of adrenaline and acute stress cause…”
Get full text
Journal Article -
4
A spectrophotometric assay for the determination of 4-diphosphocytidyl-2- C-methyl- d-erythritol kinase activity
Published in Analytical biochemistry (15-05-2005)“…We report an assay for the determination of the activity of 4-diphosphocytidyl-2- C-methyl- d-erythritol kinase, the enzyme which catalyzes the fourth reaction…”
Get full text
Journal Article -
5
Generation of recombinant hyperimmune globulins from diverse B-cell repertoires
Published in Nature biotechnology (01-08-2021)“…Plasma-derived polyclonal antibody therapeutics, such as intravenous immunoglobulin, have multiple drawbacks, including low potency, impurities, insufficient…”
Get full text
Journal Article -
6
Clinical performance of an antibody-free assay for plasma Aβ42/Aβ40 to detect early alterations of Alzheimer's disease in individuals with subjective cognitive decline
Published in Alzheimer's research & therapy (05-01-2023)“…Accessible and cost-effective diagnostic tools are urgently needed to accurately quantify blood biomarkers to support early diagnosis of Alzheimer's disease…”
Get full text
Journal Article -
7
Clinical utility of an antibody‐free LC‐MS method to detect brain amyloid deposition in cognitively unimpaired individuals from the screening visit of the A4 Study
Published in Alzheimer's & dementia : diagnosis, assessment & disease monitoring (01-04-2023)“…INTRODUCTION This study explored the ability of plasma amyloid beta (Aβ)42/Aβ40 to identify brain amyloid deposition in cognitively unimpaired (CU)…”
Get full text
Journal Article -
8
Multiterapia de la Hanseniasis en Europa
Published in Hansenologia internationalis (30-06-1998)Get full text
Journal Article -
9
GMP Manufacturing and IND-Enabling Studies of a Recombinant Hyperimmune Globulin Targeting SARS-CoV-2
Published in Pathogens (Basel) (19-07-2022)“…Conventionally, hyperimmune globulin drugs manufactured from pooled immunoglobulins from vaccinated or convalescent donors have been used in treating…”
Get full text
Journal Article -
10
Recaídas en Hanseniasis: experiencia personal
Published in Hansenologia internationalis (30-11-1999)“…En un total de 451 pacientes tratados con Monoterapia con Sulfonas, se han observado 31 recaídas, 15 de ellas de forma dimorfa. El intervalo de tiempo entre…”
Get full text
Journal Article -
11
AB1601 Phase 2 Study of ABvac40, an Anti‐Aβ40 Vaccine: Safety and Immunogenicity of a Cross‐Over Extension
Published in Alzheimer's & dementia (01-12-2023)“…Background Amyloid‐β (Aβ) immunotherapy is a promising strategy for treating Alzheimer’s disease (AD). Previous studies suggested that Aβ40 could have an…”
Get full text
Journal Article -
12
Design, synthesis and biological activity of acyl substituted 3-amino-5-methyl-1,4,5,7-tetrahydropyrazolo[3,4-b]pyridin-6-ones as potential hypnotic drugs
Published in European journal of medicinal chemistry (01-11-2005)“…Among the known non-benzodiazepinic hypnotic drugs acting on the α1 subunit of the GABA-A receptor, Zolpidem (2a), Zaleplon (1b) and Indiplon (1a) have showed…”
Get full text
Journal Article -
13
Situación de la lepra en el mundo
Published in Medicina cutánea ibero-latino-americana (01-09-2005)Get full text
Journal Article -
14
Clinical performance of an antibody-free assay for plasma A[beta]42/A[beta]40 to detect early alterations of Alzheimer's disease in individuals with subjective cognitive decline
Published in Alzheimer's research & therapy (05-01-2023)“…Background Accessible and cost-effective diagnostic tools are urgently needed to accurately quantify blood biomarkers to support early diagnosis of Alzheimer's…”
Get full text
Journal Article -
15
-
16
Synthesis, pharmacology and molecular modeling of N-substituted 2-phenyl-indoles and benzimidazoles as potent GABA A agonists
Published in European journal of medicinal chemistry (01-08-2006)“…Among the known non-benzodiazepine hypnotic drugs, Zolpidem ( 1a), Indiplon ( 2a) and Zaleplon ( 2b) have shown high affinity and selectivity for the α 1…”
Get full text
Journal Article -
17
-
18