Search Results - "Terasaka, Naoki"

HDL, ABC Transporters, and Cholesterol Efflux: Implications for the Treatment of Atherosclerosis by Tall, Alan R., Yvan-Charvet, Laurent, Terasaka, Naoki, Pagler, Tamara, Wang, Nan

“…High-density lipoprotein (HDL) has been identified as a potential target in the treatment of atherosclerotic vascular disease. The failure of torcetrapib, an…”
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Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice by Yvan-Charvet, Laurent, Ranalletta, Mollie, Wang, Nan, Han, Seongah, Terasaka, Naoki, Li, Rong, Welch, Carrie, Tall, Alan R

“…HDLs protect against the development of atherosclerosis, but the underlying mechanisms are poorly understood. HDL and its apolipoproteins can promote…”
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High-density lipoprotein protects macrophages from oxidized low-density lipoprotein-induced apoptosis by promoting efflux of 7-ketocholesterol via ABCG1 by Terasaka, Naoki, Wang, Nan, Yvan-Charvet, Laurent, Tall, Alan R

“…Oxidized sterols consumed in the diet or formed on low-density lipoprotein (LDL) are toxic to endothelial cells and macrophages and are thought to have a…”
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Estimating the prevalence, clinical characteristics, and treatment patterns of hypertrophic cardiomyopathy in Japan: A nationwide medical claims database study by Terasaka, Naoki, Spanopoulos, Dionysis, Miyagoshi, Hidetaka, Kubo, Toru, Kitaoka, Hiroaki

“…Limited data are available regarding therapies for hypertrophic cardiomyopathy (HCM). This study assessed the prevalence, clinical characteristics, and…”
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Novel LCAT (Lecithin:Cholesterol Acyltransferase) Activator DS-8190a Prevents the Progression of Plaque Accumulation in Atherosclerosis Models by Sasaki, Masato, Delawary, Mina, Sakurai, Hidetaka, Kobayashi, Hideki, Nakao, Naoki, Tsuru, Hiromi, Fukushima, Yumiko, Honzumi, Shoko, Moriyama, Sachiko, Wada, Naoya, Kaneko, Toshio, Yamada, Keisuke, Terasaka, Naoki, Kubota, Kazuishi

“…OBJECTIVE:Enhancement of LCAT (lecithin:cholesterol acyltransferase) activity has possibility to be beneficial for atherosclerosis. To evaluate this concept,…”
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Safety and Effectiveness of Four-Factor Prothrombin Complex Concentrate in Special Populations with INR Below 2: A Post-Marketing Surveillance Study by Yasaka, Masahiro, Shimizu, Fumihiko, Niwa, Yuki, Kiyonaga, Ayako, Terasaka, Naoki

“…Introduction We previously conducted a prospective, observational post-marketing surveillance study to assess the safety and effectiveness of four-factor…”
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ABCG1 and HDL protect against endothelial dysfunction in mice fed a high-cholesterol diet by Terasaka, Naoki, Yu, Shuiqing, Yvan-Charvet, Laurent, Wang, Nan, Mzhavia, Nino, Langlois, Read, Pagler, Tamara, Li, Rong, Welch, Carrie L, Goldberg, Ira J, Tall, Alan R

“…Plasma HDL levels are inversely related to the incidence of atherosclerotic disease. Some of the atheroprotective effects of HDL are likely mediated via…”
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Real-World Safety and Effectiveness of a 4-Factor Prothrombin Complex Concentrate in Japanese Patients Experiencing Major Bleeding: A Post-marketing Surveillance Study by Yasaka, Masahiro, Suzuki, Michiyasu, Kushimoto, Shigeki, Kiyonaga, Ayako, Mangione, Antoinette, Niwa, Yuki, Terasaka, Naoki

“…Introduction Limited data are available regarding the safety and effectiveness of 4-factor prothrombin complex concentrate (4F-PCC) in patients experiencing…”
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Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice by OKAMOTO, Yoshihisa, KIHARA, Shinji, TERASAKA, Naoki, INABA, Toshimori, FUNAHASHI, Tohru, MATSUZAWA, Yuji, OUCHI, Noriyuki, NISHIDA, Makoto, ARITA, Yukio, KUMADA, Masahiro, OHASHI, Koji, SAKAI, Naohiko, SHIMOMURA, Iichiro, KOBAYASHI, Hideki

“…Dysregulation of adipocyte-derived bioactive molecules plays an important role in the development of atherosclerosis. We previously reported that adiponectin,…”
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ACAT inhibitor pactimibe sulfate (CS-505) reduces and stabilizes atherosclerotic lesions by cholesterol-lowering and direct effects in apolipoprotein E-deficient mice by Terasaka, Naoki, Miyazaki, Atsuhiro, Kasanuki, Naomi, Ito, Kayoko, Ubukata, Naoko, Koieyama, Tadashi, Kitayama, Ken, Tanimoto, Tatsuo, Maeda, Naoyuki, Inaba, Toshimori

“…Abstract The objective of the present study was to determine whether a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, pactimibe sulfate (CS-505),…”
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Importance of acyl-coenzyme A:cholesterol acyltransferase 1/2 dual inhibition for anti-atherosclerotic potency of pactimibe by Kitayama, Ken, Tanimoto, Tatsuo, Koga, Teiichiro, Terasaka, Naoki, Fujioka, Tomoyuki, Inaba, Toshimori

“…Pactimibe sulfate, [7-(2,2-dimethylpropanamido)-4,6-dimethyl-1-octylindolin-5-yl]acetic acid hemisulfate, a novel Acyl-coenzyme A:cholesterol acyltransferase…”
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Angiopoietin-like Protein 3 Mediates Hypertriglyceridemia Induced by the Liver X Receptor by Inaba, Toshimori, Matsuda, Morihiro, Shimamura, Mitsuru, Takei, Norihide, Terasaka, Naoki, Ando, Yosuke, Yasumo, Hiroaki, Koishi, Ryuta, Makishima, Makoto, Shimomura, Iichiro

“…The KK/San obese and diabetic mouse, a mutant strain from KK obese mice, exhibits significantly low plasma triglyceride levels. In KK/San mice, genetic…”
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Real‐world safety and treatment patterns of subcutaneous IgPro20 for chronic inflammatory demyelinating polyneuropathy: Post‐marketing surveillance in Japan by Terasaka, Naoki, Mizushima, Takanori, Niwa, Yuki, Akasaki, Tetsushi, Usui, Hideo

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Thrombotic and Cardiovascular Events and Treatment Patterns Among Patients Hospitalized with COVID-19 in Japan: An Analysis of a Nationwide Medical Claims Database by Terasaka, Naoki, Matsuo, Yukako, Kataoka, Hirohide, Miyata, Yasuhiko, Anazawa, Yoshio

“…Introduction Limited data are available regarding the prevalence of thrombotic/cardiovascular disease and treatment patterns for patients with coronavirus…”
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Synthetic LXR agonist inhibits the development of atherosclerosis in New Zealand White rabbits by Honzumi, Shoko, Shima, Akiko, Hiroshima, Ayano, Koieyama, Tadashi, Terasaka, Naoki

“…The nuclear receptors Liver X receptors, LXRα and LXRβ, regulate cholesterol and triglyceride metabolism. We and others have previously reported that synthetic…”
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ATP-Binding Cassette Transporter G1 and High-Density Lipoprotein Promote Endothelial NO Synthesis Through a Decrease in the Interaction of Caveolin-1 and Endothelial NO Synthase by Terasaka, Naoki, Westerterp, Marit, Koetsveld, Joris, Fernández-Hernando, Carlos, Yvan-Charvet, Laurent, Wang, Nan, Sessa, William C, Tall, Alan R

“…OBJECTIVE—To investigate whether cholesterol efflux to high-density lipoprotein (HDL) via ATP-binding cassette transporter G1 (ABCG1) modulates the interaction…”
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T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice by Terasaka, Naoki, Hiroshima, Ayano, Koieyama, Tadashi, Ubukata, Naoko, Morikawa, Yuka, Nakai, Daisuke, Inaba, Toshimori

“…Liver X receptors (LXRα and LXRβ) are nuclear receptors, which are important regulators of cholesterol and lipid metabolism. LXRs control genes involved in…”
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LXRα regulates human CETP expression in vitro and in transgenic mice by Honzumi, Shoko, Shima, Akiko, Hiroshima, Ayano, Koieyama, Tadashi, Ubukata, Naoko, Terasaka, Naoki

“…Abstract Liver X receptors (LXRs), LXRα and LXRβ, are members of the nuclear receptor superfamily and regulate the expression of genes involved in the…”
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Discovery and structure-guided optimization of tert-butyl 6-(phenoxymethyl)-3-(trifluoromethyl)benzoates as liver X receptor agonists by Matsui, Yumi, Yamaguchi, Takahiro, Yamazaki, Takanori, Yoshida, Masayuki, Arai, Masami, Terasaka, Naoki, Honzumi, Shoko, Wakabayashi, Kenji, Hayashi, Shinko, Nakai, Daisuke, Hanzawa, Hiroyuki, Tamaki, Kazuhiko

“…[Display omitted] To obtain potent liver X receptor (LXR) agonists, a structure–activity relationship study was performed on a series of tert-butyl benzoate…”
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Liver X receptor agonists inhibit tissue factor expression in macrophages by Terasaka, Naoki, Hiroshima, Ayano, Ariga, Akiko, Honzumi, Shoko, Koieyama, Tadashi, Inaba, Toshimori, Fujiwara, Toshihiko

“…Exposure of blood to tissue factor (TF) rapidly initiates the coagulation serine protease cascades. TF is expressed by macrophages and other types of cell…”
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