Search Results - "Terasaka, Naohiro"

Laboratory evolution of virus-like nucleocapsids from nonviral protein cages by Terasaka, Naohiro, Azuma, Yusuke, Hilvert, Donald

“…Viruses are remarkable nanomachines that efficiently hijack cellular functions to replicate and self-assemble their components within a complex biological…”
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An aminoacylation ribozyme evolved from a natural tRNA-sensing T-box riboswitch by Ishida, Satoshi, Terasaka, Naohiro, Katoh, Takayuki, Suga, Hiroaki

“…When the primitive translation system first emerged in the hypothetical RNA world, ribozymes could have been responsible for aminoacylation. Given that…”
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An orthogonal ribosome-tRNA pair via engineering of the peptidyl transferase center by Terasaka, Naohiro, Hayashi, Gosuke, Katoh, Takayuki, Suga, Hiroaki

“…Genetic code reprogramming has generally focused on changing the translation step of protein expression, altering what each codon specifies. Mutations in the…”
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De Novo Discovery of Thiopeptide Pseudo-natural Products Acting as Potent and Selective TNIK Kinase Inhibitors by Vinogradov, Alexander A., Zhang, Yue, Hamada, Keisuke, Chang, Jun Shi, Okada, Chikako, Nishimura, Hirotaka, Terasaka, Naohiro, Goto, Yuki, Ogata, Kazuhiro, Sengoku, Toru, Onaka, Hiroyasu, Suga, Hiroaki

“…Bioengineering of ribosomally synthesized and post-translationally modified peptides (RiPPs) is an emerging approach to explore the diversity of pseudo-natural…”
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A human microRNA precursor binding to folic acid discovered by small RNA transcriptomic SELEX by Terasaka, Naohiro, Futai, Kazuki, Katoh, Takayuki, Suga, Hiroaki

“…RNA aptamers are structured motifs that bind to specific molecules. A growing number of RNAs bearing aptamer elements, whose functions are modulated by direct…”
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Flexizymes-facilitated Genetic Code Reprogramming Leading to the Discovery of Drug-like Peptides by Terasaka, Naohiro, Suga, Hiroaki

“…Flexizymes are a family of aminoacylation ribozymes devised by in vitro selection in our research group. They charge a wide variety of nonproteinogenic amino…”
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Macrocyclic Peptide-Conjugated Tip for Fast and Selective Molecular Recognition Imaging by High-Speed Atomic Force Microscopy by Puppulin, Leonardo, Kanayama, Daiki, Terasaka, Naohiro, Sakai, Katsuya, Kodera, Noriyuki, Umeda, Kenichi, Sumino, Ayumi, Marchesi, Arin, Weilin, Wei, Tanaka, Hideo, Fukuma, Takeshi, Suga, Hiroaki, Matsumoto, Kunio, Shibata, Mikihiro

“…Fast and selective recognition of molecules at the nanometer scale without labeling is a much desired but still challenging goal to achieve. Here, we show the…”
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Cytoplasmic glycoengineering enables biosynthesis of nanoscale glycoprotein assemblies by Tytgat, Hanne L. P., Lin, Chia-wei, Levasseur, Mikail D., Tomek, Markus B., Rutschmann, Christoph, Mock, Jacqueline, Liebscher, Nora, Terasaka, Naohiro, Azuma, Yusuke, Wetter, Michael, Bachmann, Martin F., Hilvert, Donald, Aebi, Markus, Keys, Timothy G.

“…Glycosylation of proteins profoundly impacts their physical and biological properties. Yet our ability to engineer novel glycoprotein structures remains…”
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tRid, an enabling method to isolate previously inaccessible small RNA fractions by Futai, Kazuki, Terasaka, Naohiro, Katoh, Takayuki, Suga, Hiroaki

“…[Display omitted] Detection of rare small RNA species whose sizes are overlapping with tRNAs often suffers from insufficient sensitivity due to the…”
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In vitro selection of macrocyclic peptide inhibitors containing cyclic γ2,4-amino acids targeting the SARS-CoV-2 main protease by Miura, Takashi, Malla, Tika R., Owen, C. David, Tumber, Anthony, Brewitz, Lennart, McDonough, Michael A., Salah, Eidarus, Terasaka, Naohiro, Katoh, Takayuki, Lukacik, Petra, Strain-Damerell, Claire, Mikolajek, Halina, Walsh, Martin A., Kawamura, Akane, Schofield, Christopher J., Suga, Hiroaki

“…γ-Amino acids can play important roles in the biological activities of natural products; however, the ribosomal incorporation of γ-amino acids into peptides is…”
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Recent developments of engineered translational machineries for the incorporation of non-canonical amino acids into polypeptides by Terasaka, Naohiro, Iwane, Yoshihiko, Geiermann, Anna-Skrollan, Goto, Yuki, Suga, Hiroaki

“…Genetic code expansion and reprogramming methodologies allow us to incorporate non-canonical amino acids (ncAAs) bearing various functional groups, such as…”
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Generation of non-standard macrocyclic peptides specifically binding TSC-22 homologous gene-1 by Tran, Sophie T. PhuongDung, Hipolito, Christopher J., Suzuki, Hiroyuki, Xie, Rudy, Kim Tuyen, Huynh Dam, Dijke, Peter ten, Terasaka, Naohiro, Goto, Yuki, Suga, Hiroaki, Kato, Mitsuyasu

“…Transforming growth factor-β 1 (TGFβ1)-stimulated clone 22 (TSC22) family includes proteins containing a leucine zipper domain and a TSC-box that are highly…”
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The RNA origin of transfer RNA aminoacylation and beyond by Suga, Hiroaki, Hayashi, Gosuke, Terasaka, Naohiro

“…Aminoacylation of tRNA is an essential event in the translation system. Although in the modern system protein enzymes play the sole role in tRNA…”
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Structural basis of tRNA agmatinylation essential for AUA codon decoding by Numata, Tomoyuki, Osawa, Takuo, Kimura, Satoshi, Terasaka, Naohiro, Inanaga, Hideko, Suzuki, Tsutomu

“…TiaS catalyzes the transfer of agmatine onto the first position cytidine of the tRNAIle2 anticodon in archaea, ensuring proper translation of the matching…”
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De novo peptide grafting to a self-assembling nanocapsule yields a hepatocyte growth factor receptor agonist by Komatsu, Yamato, Terasaka, Naohiro, Sakai, Katsuya, Mihara, Emiko, Wakabayashi, Risa, Matsumoto, Kunio, Hilvert, Donald, Takagi, Junichi, Suga, Hiroaki

“…Lasso-grafting (LG) technology is a method for generating de novo biologics (neobiologics) by genetically implanting macrocyclic peptide pharmacophores, which…”
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MET‐Activating Ubiquitin Multimers by Kawakami, Naoya, Sato, Hiroki, Terasaka, Naohiro, Matsumoto, Kunio, Suga, Hiroaki

“…Receptor tyrosine kinases (RTKs) are generally activated through their dimerization and/or oligomerization induced by their cognate ligands, and one such RTK…”
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De Novo Single-Stranded RNA-Binding Peptides Discovered by Codon-Restricted mRNA Display by Nishikawa, Shota, Watanabe, Hidenori, Terasaka, Naohiro, Katoh, Takayuki, Fujishima, Kosuke

“…RNA-binding proteins participate in diverse cellular processes, including DNA repair, post-transcriptional modification, and cancer progression through their…”
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An anticodon-sensing T-boxzyme generates the elongator nonproteinogenic aminoacyl-tRNA in situ of a custom-made translation system for incorporation by Lu, Wei, Terasaka, Naohiro, Sakaguchi, Yuriko, Suzuki, Takeo, Suzuki, Tsutomu, Suga, Hiroaki

“…In the hypothetical RNA world, ribozymes could have acted as modern aminoacyl-tRNA synthetases (ARSs) to charge tRNAs, thus giving rise to the peptide…”
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Evolution of a virus-like architecture and packaging mechanism in a repurposed bacterial protein by Tetter, Stephan, Terasaka, Naohiro, Steinauer, Angela, Bingham, Richard J, Clark, Sam, Scott, Andrew J P, Patel, Nikesh, Leibundgut, Marc, Wroblewski, Emma, Ban, Nenad, Stockley, Peter G, Twarock, Reidun, Hilvert, Donald

“…Viruses are ubiquitous pathogens of global impact. Prompted by the hypothesis that their earliest progenitors recruited host proteins for virion formation, we…”
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Modular Protein Cages for Size-Selective RNA Packaging in Vivo by Azuma, Yusuke, Edwardson, Thomas G. W, Terasaka, Naohiro, Hilvert, Donald

“…Protein cages have recently emerged as an important platform for nanotechnology development. Of the naturally existing protein cages, viruses are among the…”
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