Search Results - "Teraoka, Hirobumi"

ATM and SIRT6/SNF2H Mediate Transient H2AX Stabilization When DSBs Form by Blocking HUWE1 to Allow Efficient γH2AX Foci Formation by Atsumi, Yuko, Minakawa, Yusuke, Ono, Masaya, Dobashi, Sachiko, Shinohe, Keitaro, Shinohara, Akira, Takeda, Shunichi, Takagi, Masatoshi, Takamatsu, Nobuhiko, Nakagama, Hitoshi, Teraoka, Hirobumi, Yoshioka, Ken-ichi

“…In response to DNA double-strand breaks (DSBs), H2AX is rapidly phosphorylated at Ser139 to promote DSB repair. Here we show that H2AX is rapidly stabilized in…”
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Induction of Cancerous Stem Cells during Embryonic Stem Cell Differentiation by Fujimori, Hiroaki, Shikanai, Mima, Teraoka, Hirobumi, Masutani, Mitsuko, Yoshioka, Ken-ichi

“…Stem cell maintenance depends on their surrounding microenvironment, and aberrancies in the environment have been associated with tumorigenesis. However, it…”
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Phosphorylation of histone H2AX at M phase in human cells without DNA damage response by Ichijima, Yosuke, Sakasai, Ryo, Okita, Naoyuki, Asahina, Kinji, Mizutani, Shuki, Teraoka, Hirobumi

“…A variant of histone H2A, H2AX, is phosphorylated on Ser139 in response to DNA double-strand breaks (DSBs), and clusters of the phosphorylated form of H2AX…”
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Transcription-dependent Activation of Ataxia Telangiectasia Mutated Prevents DNA-dependent Protein Kinase-mediated Cell Death in Response to Topoisomerase I Poison by Sakasai, Ryo, Teraoka, Hirobumi, Takagi, Masatoshi, Tibbetts, Randal S.

“…Camptothecin (CPT) is a topoisomerase I inhibitor, derivatives of which are being used for cancer chemotherapy. CPT-induced DNA double-strand breaks (DSBs) are…”
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DNA lesions induced by replication stress trigger mitotic aberration and tetraploidy development by Ichijima, Yosuke, Yoshioka, Ken-ichi, Yoshioka, Yoshiko, Shinohe, Keitaro, Fujimori, Hiroaki, Unno, Junya, Takagi, Masatoshi, Goto, Hidemasa, Inagaki, Masaki, Mizutani, Shuki, Teraoka, Hirobumi

“…During tumorigenesis, cells acquire immortality in association with the development of genomic instability. However, it is still elusive how genomic…”
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Developmental Pluripotency-associated 4 (DPPA4) Localized in Active Chromatin Inhibits Mouse Embryonic Stem Cell Differentiation into a Primitive Ectoderm Lineage by Masaki, Hisaharu, Nishida, Tomohiro, Kitajima, Shigetaka, Asahina, Kinji, Teraoka, Hirobumi

“…Because embryonic stem (ES) cells can proliferate indefinitely in an undifferentiated state and differentiate into various cell types, ES cells are expected to…”
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The Arf/p53 Protein Module, Which Induces Apoptosis, Down-regulates Histone H2AX to Allow Normal Cells to Survive in the Presence of Anti-cancer Drugs by Atsumi, Yuko, Inase, Aki, Osawa, Tomoyuki, Sugihara, Eiji, Sakasai, Ryo, Fujimori, Hiroaki, Teraoka, Hirobumi, Saya, Hideyuki, Kanno, Masamoto, Tashiro, Fumio, Nakagama, Hitoshi, Masutani, Mitsuko, Yoshioka, Ken-ichi

“…Anti-cancer drugs generally target cancer cells rather than normal somatic cells. However, the factors that determine this differential sensitivity are poorly…”
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Twist Relates to Tubular Epithelial-Mesenchymal Transition and Interstitial Fibrogenesis in the Obstructed Kidney by Kida, Yujiro, Asahina, Kinji, Teraoka, Hirobumi, Gitelman, Inna, Sato, Tetsuji

“…Epithelial-mesenchymal transition (EMT) is a critical step in renal fibrosis. It has been recently reported that a transcription factor, Twist, plays a pivotal…”
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Artemis‐dependent DNA double‐strand break formation at stalled replication forks by Unno, Junya, Takagi, Masatoshi, Piao, Jinhua, Sugimoto, Masataka, Honda, Fumiko, Maeda, Daisuke, Masutani, Mitsuko, Kiyono, Tohru, Watanabe, Fumiaki, Morio, Tomohiro, Teraoka, Hirobumi, Mizutani, Shuki

“…Stalled replication forks undergo DNA double‐strand breaks (DSBs) under certain conditions. However, the precise mechanism underlying DSB induction and the…”
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Human Umbilical Cord Blood as a Source of Transplantable Hepatic Progenitor Cells by Kakinuma, Sei, Tanaka, Yujiro, Chinzei, Ryoko, Watanabe, Mamoru, Shimizu‐saito, Keiko, Hara, Yuzuru, Teramoto, Kenichi, Arii, Shigeki, Sato, Chifumi, Takase, Kozo, Yasumizu, Takehiko, Teraoka, Hirobumi

“…Human umbilical cord blood (UCB) cells have many advantages as grafts for cell transplantation because of the immaturity of newborn cells compared with adult…”
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Onset of quiescence following p53 mediated down-regulation of H2AX in normal cells by Atsumi, Yuko, Fujimori, Hiroaki, Fukuda, Hirokazu, Inase, Aki, Shinohe, Keitaro, Yoshioka, Yoshiko, Shikanai, Mima, Ichijima, Yosuke, Unno, Junya, Mizutani, Shuki, Tsuchiya, Naoto, Hippo, Yoshitaka, Nakagama, Hitoshi, Masutani, Mitsuko, Teraoka, Hirobumi, Yoshioka, Ken-ichi

“…Normal cells, both in vivo and in vitro, become quiescent after serial cell proliferation. During this process, cells can develop immortality with genomic…”
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RAD18 and Poly(ADP-Ribose) Polymerase Independently Suppress the Access of Nonhomologous End Joining to Double-Strand Breaks and Facilitate Homologous Recombination-Mediated Repair by Saberi, Alihossein, Hochegger, Helfrid, Szuts, David, Lan, Li, Yasui, Akira, Sale, Julian E., Taniguchi, Yoshihito, Murakawa, Yasuhiro, Zeng, Weihua, Yokomori, Kyoko, Helleday, Thomas, Teraoka, Hirobumi, Arakawa, Hiroshi, Buerstedde, Jean-Marie, Takeda, Shunichi

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The quiescent cellular state is Arf/p53-dependent and associated with H2AX downregulation and genome stability by Yoshioka, Ken-Ichi, Atsumi, Yuko, Fukuda, Hirokazu, Masutani, Mitsuko, Teraoka, Hirobumi

“…Cancer is a disease associated with genomic instability and mutations. Excluding some tumors with specific chromosomal translocations, most cancers that…”
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Expression of the liver‐specific gene Cyp7a1 reveals hepatic differentiation in embryoid bodies derived from mouse embryonic stem cells by Asahina, Kinji, Fujimori, Hiroaki, Shimizu‐Saito, Keiko, Kumashiro, Yuji, Okamura, Kentaro, Tanaka, Yujiro, Teramoto, Kenichi, Arii, Shigeki, Teraoka, Hirobumi

“…Hepatic differentiation from mouse embryonic stem (ES) cells via the formation of embryoid bodies (EBs) has been revealed by the expression of…”
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Parp-1 deficiency causes an increase of deletion mutations and insertions/ rearrangements in vivo after treatment with an alkylating agent by SHIBATA, Atsushi, KAMADA, Nobuo, MASUMURA, Ken-Ichi, NOHMI, Takehiko, KOBAYASHI, Shizuko, TERAOKA, Hirobumi, NAKAGAMA, Hitoshi, SUGIMURA, Takashi, SUZUKI, Hiroshi, MASUTANI, Mitsuko

“…Accumulated evidence suggests that Parp-1 is involved in DNA repair processes, including base excision repair, single-strand and double-strand break repairs…”
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Enrichment of hepatocytes differentiated from mouse embryonic stem cells as a transplantable source by KUMASHIRO, Yuji, ASAHINA, Kinji, ARII, Shigeki, TERAOKA, Hirobumi, OZEKI, Rie, SHIMIZU-SAITO, Keiko, TANAKA, Yujiro, KIDA, Yujiro, INOUE, Kouji, KANEKO, Michinari, SATO, Tetsuji, TERAMOTO, Kenichi

“…We previously reported that hepatocytes can be differentiated from embryonic stem (ES) cells by way of embryoid body (EB) formation and are transplantable into…”
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Vascular endothelial growth factor promotes proliferation and function of hepatocyte-like cells in embryoid bodies formed from mouse embryonic stem cells by Fujimori, Hiroaki, Asahina, Kinji, Shimizu-Saito, Keiko, Ikeda, Reiko, Tanaka, Yujiro, Teramoto, Kenichi, Morita, Ikuo, Teraoka, Hirobumi

“…Background/Aims Embryoid bodies (EBs) formed from embryonic stem cells (ESCs) differentiate into hepatocyte-like cells (HLCs), and are thus thought to be a…”
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Hepatic stellate cells mediate differentiation of dendritic cells from monocytes by Ozeki, Rie, Kakinuma, Sei, Asahina, Kinji, Shimizu-Saito, Keiko, Arii, Shigeki, Tanaka, Yujiro, Teraoka, Hirobumi

“…We have previously reported that human umbilical cord blood (UCB)-nucleated cells differentiate into hepatocyte-like cells when cultured in a 5-cytokine…”
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Hepatic progenitor cells in the mouse extrahepatic bile duct after a bile duct ligation by Irie, Takumi, Asahina, Kinji, Shimizu-Saito, Keiko, Teramoto, Kenichi, Arii, Shigeki, Teraoka, Hirobumi

“…The intrahepatic bile duct has been suggested to be a source of hepatic progenitor cells in the severely damaged liver. In contrast, little attention has been…”
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Differential involvement of phosphatidylinositol 3‐kinase‐related protein kinases in hyperphosphorylation of replication protein A2 in response to replication‐mediated DNA double‐strand breaks by Sakasai, Ryo, Shinohe, Keitaro, Ichijima, Yosuke, Okita, Naoyuki, Shibata, Atsushi, Asahina, Kinji, Teraoka, Hirobumi

“…Replication protein A2 (RPA2), a component of the RPA heterotrimer, is hyperphosphorylated and forms nuclear foci in response to camptothecin (CPT) that…”
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