Hypothyroidism after radiotherapy for laryngeal cancer

Hypothyroidism after radiotherapy for laryngeal cancer

Purpose: To investigate the incidence of hypothyroidism after radiotherapy of laryngeal cancer, including the possible factors that could predict the onset of hypothyroidism. Materials and methods: We report this study on patients treated by radiotherapy as part of the treatment for laryngeal cancer...

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Bibliographic Details
Published in:Radiotherapy and oncology Vol. 57; no. 1; pp. 97 - 101
Main Authors: Kumpulainen, Eero J, Hirvikoski, Pasi P, Virtaniemi, Jukka A, Johansson, Risto T, Simonen, Päivi M, Terävä, Markku T, Asikainen, Raimo J, Nykänen, Kalevi J, Kosma, Veli-Matti
Format: Journal Article
Language:English
Published: Ireland Elsevier Ireland Ltd 01-10-2000
Subjects:
Adult
Aged
Aged, 80 and over
Cohort Studies
Dose Fractionation, Radiation
Dose-Response Relationship, Radiation
Female
Humans
Hypothyroidism
Hypothyroidism - diagnosis
Hypothyroidism - epidemiology
Hypothyroidism - etiology
Incidence
Laryngeal neoplasms
Laryngeal Neoplasms - drug therapy
Laryngeal Neoplasms - radiotherapy
Laryngeal Neoplasms - surgery
Male
Middle Aged
Prognosis
Radiation Tolerance
Radiotherapy
Radiotherapy - adverse effects
Radiotherapy Dosage
Risk Factors
Thyroid Function Tests
Thyroid Gland - radiation effects
Radiotherapy
Hypothyroidism
Laryngeal neoplasms
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Summary:Purpose: To investigate the incidence of hypothyroidism after radiotherapy of laryngeal cancer, including the possible factors that could predict the onset of hypothyroidism. Materials and methods: We report this study on patients treated by radiotherapy as part of the treatment for laryngeal cancer in the Department of Oncology in Eastern Finland. Sixty-five males and seven females were treated with radiotherapy between 1974–1995. Thyroid function was determined by measuring serum thyroid stimulating hormone, and serum free thyroxine (FT4). The studied risk factors for hypothyroidism included age, treatment modalities, radiation dose and energy, height of the radiation field, and follow-up time. Results: Hypothyroidism was detected in 17 (24%) of the 72 patients. Hypothyroidism was clinically unsuspected in all but one patient. Hypothyroidism was more common, if the height of the radiation field was ≥7 cm, or the patient had been operated. Hypothyroidism was less common if less than a half of the thyroid bed was irradiated. Conclusion: The detection of hypothyroidism clinically is difficult, and the rate of hypothyroidism warrants routine assessment of thyroid function after irradiation of laryngeal cancer.
ISSN:0167-8140
1879-0887
DOI:10.1016/S0167-8140(00)00276-0