Search Results - "Teplow, D.B."

High-speed atomic force microscopy reveals structural dynamics of amyloid Β1-42 aggregates by Ono, K., Nakayama, T., Itami, M., Takahashi, R., Teplow, D.B., Yamada, M.

Get full text

Small assemblies of unmodified amyloid β-protein are the proximate neurotoxin in Alzheimer’s disease by Klein, W.L, Stine, W.B, Teplow, D.B

“…Pioneering work in the 1950s by Christian Anfinsen on the folding of ribonuclease has shown that the primary structure of a protein “encodes” all of the…”
Get full text

Role of Electrostatic Interactions in Amyloid β-Protein (A β) Oligomer Formation: A Discrete Molecular Dynamics Study by Yun, Sijung, Urbanc, B., Cruz, L., Bitan, G., Teplow, D.B., Stanley, H.E.

“…Pathological folding and oligomer formation of the amyloid β-protein (A β) are widely perceived as central to Alzheimer’s disease. Experimental approaches to…”
Get full text

Cryptocandin, a potent antimycotic from the endophytic fungus Cryptosporiopsis cf. quercina by Strobel, G.A, Miller, V, Martinez-Miller, C, Condron, M.M, Teplow, D.B, Hess, W.M

“…A unique lipopeptide antimycotic, termed cryptocandin, is described from Cryptosporiopsis cf. quercina, an endophytic fungus. Cryptocandin, with a molecular…”
Get full text

Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor by HAASS, C, HUNG, A. Y, SELKOE, D. J, TEPLOW, D. B

“…Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the extracellular deposition of amyloid beta-protein (A beta), a molecule…”
Get full text

beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms by HAASS, C, HUNG, A. Y, SCHLOSSMACHER, M. G, TEPLOW, D. B, SELKOE, D. J

“…We have analyzed the cellular processing pathways which produce the 4-kDa amyloid beta-peptide (A beta) and a 3-kDa derivative (p3) of the beta-amyloid…”
Get full text

Inhibition of Amyloid β-Protein Production in Neural Cells by the Serine Protease Inhibitor AEBSF by Citron, M, Diehl, T.S, Capell, A, Haass, C, Teplow, D.B, Selkoe, D.J

“…Cerebral deposition of amyloid β protein (Aβ) is an early and critical feature of Alzheimer's disease. Aβ production requires the proteolytic release of Aβ…”
Get full text

Differential effect of phosphorylation and substrate modulation on tau's ability to promote microtubule growth and nucleation by BRANDT, R, LEE, G, TEPLOW, D. B, SHALLOWAY, D, ABDEL-GHANY, M

“…The neuronal microtubule-associated protein tau promotes microtubule assembly and has been implicated in the development of axonal morphology. To study the…”
Get full text

Neuronal development in the Drosophila retina: monoclonal antibodies as molecular probes by Zipursky, S L, Venkatesh, T R, Teplow, D B, Benzer, S

“…The compound eye of D. melanogaster is a reiterative pattern of facets, each containing eight photoreceptor cells in a precise arrangement. This pattern is…”
Get more information

526 Kinetic analysis of all fibrillogenesis by Teplow, D.B., Lomakin, A.A., Benedek, G.B., Kirschner, D.A., Walsh, D.M.

Get full text

Gene regulatory factors of the sea urchin embryo. I. Purification by affinity chromatography and cloning of P3A2, a novel DNA-binding protein by CALZONE, F. J, HOOG, C, TEPLOW, D. B, CUTTING, A. E, ZELLER, R. W, BRITTEN, R. J, DAVIDSON, R. H

“…The P3A2 regulatory protein interacts with specific sites in the control region of the CyIIIa actin gene. Previous studies showed that this interaction is…”
Get full text

Biosynthesis and membrane topography of the neural cell adhesion molecule L1 by Faissner, A., Teplow, D.B., Kübler, D., Keilhauer, G., Kinzel, V., Schachner, M.

“…The biosynthesis and membrane topography of the neural cell adhesion molecule L1 have been studied in cerebellar cell cultures by metabolic labeling and…”
Get full text

In vitro phosphorylation of mouse osteopontin expressed in E. coli by Ashkar, S, Teplow, D B, Glimcher, M J, Saavedra, R A

“…To understand the role of post-translational modifications on the structure and function of osteopontin, a secreted glycosylated phosphoprotein, we expressed…”
Get more information

Primary Structure of the Human Melanoma-Associated Antigen p97 (Melanotransferrin) Deduced from the mRNA Sequence by Rose, Timothy M., Plowman, Gregory D., Teplow, David B., Dreyer, William J., Hellström, Karl Erik, Brown, Joseph P.

“…p97 is a cell-surface glycoprotein that is present in most human melanomas but only in trace amounts in normal adult tissues. To determine the structure of…”
Get full text

173 Cellular sites of APP processing and all production by Sisodia, S.S., Thinakaran, G., Teplow, D.B., Siman, R., Savage, M., Greenberg, B., Lamb, B., Wang, R., Price, D.L., Borchelt, D.

Get full text

Cloning and characterization of cDNA encoding canine alpha-L-iduronidase. mRNA deficiency in mucopolysaccharidosis I dog by Stoltzfus, L J, Sosa-Pineda, B, Moskowitz, S M, Menon, K P, Dlott, B, Hooper, L, Teplow, D B, Shull, R M, Neufeld, E F

“…alpha-L-Iduronidase is a lysosomal enzyme, the deficiency of which causes mucopolysaccharidosis I (MPS I); a canine MPS I colony has been bred to test…”
Get full text

Purification and properties of the cellular and scrapie hamster prion proteins by Turk, E, Teplow, D.B, Hood, L.E, Prusiner, S.B

“…During scrapie infection an abnormal isoform of the prion protein (PrP), designated PrPsc, accumulates and is found to copurify with infectivity; to date, no…”
Get full text

Domain of a yeast site-specific recombinase (Flp) that recognizes its target site by Chen, Jing-Wen, Evans, Barbara R., Yang, Sang-Hwa, Teplow, David B., Jayaram, Makkuni

“…Binding of a partial proteolytic digest by V8 enzyme of the yeast site-specific recombinase Flp to its target site gives rise to DNA-protein complexes that are…”
Get full text

Partial N-terminal amino acid sequences of three nonstructural proteins of two flaviviruses by Rice, C M, Aebersold, R, Teplow, D B, Pata, J, Bell, J R, Vorndam, A V, Trent, D W, Brandriss, M W, Schlesinger, J J, Strauss, J H

“…Partial N-terminal amino acid sequences for the three largest nonstructural proteins of two flaviviruses, yellow fever virus and St. Louis encephalitis virus,…”
Get more information