Search Results - "Tephly, Thomas R."

N-GLUCURONIDATION OF PERFLUOROOCTANESULFONAMIDE BY HUMAN, RAT, DOG, AND MONKEY LIVER MICROSOMES AND BY EXPRESSED RAT AND HUMAN UDP-GLUCURONOSYLTRANSFERASES by LIN XU, KRENITSKY, Daria M, SEACAT, Andrew M, BUTENHOFF, John L, TEPHLY, Thomas R, ANDERS, M. W

“…N -Alkylperfluorooctanesulfonamides have been used in a range of industrial and commercial applications. Perfluorooctanesulfonamide (FOSA) is a major…”
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Differential glucuronidation of bile acids, androgens and estrogens by human UGT1A3 and 2B7 by Gall, Walter E, Zawada, Gregory, Mojarrabi, Behnaz, Tephly, Thomas R, Green, Mitchell D, Coffman, Birgit L, Mackenzie, Peter I, Radominska-Pandya, Anna

“…In this work, UDP-glucuronosyltransferases (UGTs), UGT1A3, 2B7(H268) and 2B7(Y268), stably expressed in human embryonic kidney cells (HK293) were used to…”
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Inhibition and Active Sites of UDP-Glucuronosyltransferases 2B7 and 1A1 by RIOS, Gladys R, TEPHLY, Thomas R

“…Two human UDP-glucuronosyltransferases (UGTs), UGT2B7 and UGT1A1, catalyze the glucuronidation of many endo- and xenobiotics. Although UGT1A1 uniquely…”
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Opioids bind to the amino acids 84 to 118 of UDP-glucuronosyltransferase UGT2B7 by Coffman, Birgit L, Kearney, William R, Goldsmith, Shawn, Knosp, Boyd M, Tephly, Thomas R

“…The UDP-glucuronosyltransferase UGT2B7 is an important human UGT isoform that catalyzes the conjugation of many endogenous and exogenous compounds, among them…”
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The Glucuronidation of Opioids, Other Xenobiotics, and Androgens by Human UGT2B7Y(268) and UGT2B7H(268) by COFFMAN, B. L, KING, C. D, RIOS, G. R, TEPHLY, T. R

“…UGT2B7 has been cloned and expressed previously in COS cells and HK293 cells. Two forms have been identified: one with a tyrosine and one with a histidine at…”
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Studies on the Substrate Specificity of Human Intestinal UDP-Glucuronosyltransferases 1A8 and 1A10 by Ziqiang Cheng, Anna Radominska-Pandya, Thomas R. Tephly

“…Although the liver has been considered the most important organ involved in glucuronidation, recent studies have focused on the role of the gastrointestinal…”
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Glucuronidation of Amine Substrates by Purified and Expressed UDP-Glucuronosyltransferase Proteins by Green, M D, Tephly, T R

“…Conjugation of many primary, secondary, and tertiary amine–containing xenobiotics with glucuronic acid can result in the formation of N -glucuronide…”
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Glucuronidation of Amines and Other Xenobiotics Catalyzed by Expressed Human UDP-Glucuronosyltransferase 1A3 by GREEN, M. D, KING, C. D, MOJARRABI, B, MACKENZIE, P. I, TEPHLY, T. R

“…Glucuronide conjugation of xenobiotics containing a tertiary amine moiety represents a unique and important metabolic pathway for these compounds in humans…”
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Aspartame: Review of Safety by Butchko, Harriett H., Stargel, W.Wayne, Comer, C.Phil, Mayhew, Dale A., Benninger, Christian, Blackburn, George L., de Sonneville, Leo M.J., Geha, Raif S., Hertelendy, Zsolt, Koestner, Adalbert, Leon, Arthur S., Liepa, George U., McMartin, Kenneth E., Mendenhall, Charles L., Munro, Ian C., Novotny, Edward J., Renwick, Andrew G., Schiffman, Susan S., Schomer, Donald L., Shaywitz, Bennett A., Spiers, Paul A., Tephly, Thomas R., Thomas, John A., Trefz, Friedrich K.

“…Over 20 years have elapsed since aspartame was approved by regulatory agencies as a sweetener and flavor enhancer. The safety of aspartame and its metabolic…”
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Cloning and Expression of Human UDP-Glucuronosyltransferase (UGT) 1A8 by Cheng, Ziqiang, Radominska-Pandya, Anna, Tephly, Thomas R.

“…The mRNA expression of human UDP-glucuronosyltransferase 1A8 (UGT1A8) has been found in jejunum, ileum, and colon but not in liver. A cDNA with a complete…”
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4-Hydroxyretinoic Acid, a Novel Substrate for Human Liver Microsomal UDP-glucuronosyltransferase(s) and Recombinant UGT2B7 by Samokyszyn, Victor M., Gall, Walter E., Zawada, Gregory, Freyaldenhoven, Mary Ann, Chen, Guangping, Mackenzie, Peter I., Tephly, Thomas R., Radominska-Pandya, Anna

“…It is suggested that formation of more polar metabolites of all-trans-retinoic acid (atRA) via oxidative pathways limits its biological activity. In this…”
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Expression of UGT2B7, a UDP-Glucuronosyltransferase Implicated in the Metabolism of 4-Hydroxyestrone and All- Trans Retinoic Acid, in Normal Human Breast Parenchyma and in Invasive and in Situ Breast Cancers by Gestl, Shelley A., Green, Mitchell D., Shearer, Debra A., Frauenhoffer, Elizabeth, Tephly, Thomas R., Weisz, Judith

“…Glucuronidation, mediated by UDP-glucuronosyltransferases (UGTs), affects the actions and disposition of diverse endo- and xenobiotics. In the case of…”
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The Glucuronidation of Exogenous and Endogenous Compounds by Stably Expressed Rat and Human UDP-Glucuronosyltransferase 1.1 by King, Christopher D., Green, Mitchell D., Rios, Gladys R., Coffman, Birgit L., Owens, Ida S., Bishop, Warren P., Tephly, Thomas R.

“…Rat and human UDP-glucuronosyltransferase (UGT)1.1 share >70% identity in their deduced primary amino acid sequences. We have previously shown that rat UGT1.1,…”
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Analysis of opioid binding to UDP-glucuronosyltransferase 2B7 fusion proteins using nuclear magnetic resonance spectroscopy by Coffman, B L, Kearney, W R, Green, M D, Lowery, R G, Tephly, T R

“…The UDP-glucuronosyltransferase UGT2B7 is an important human UGT isoform that catalyzes the conjugation of many endogenous and exogenous compounds, among them…”
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Comparison of Stably Expressed Rat UGT1.1 and UGT2B1 in the Glucuronidation of Opioid Compounds by KING, C. D, RIOS, G. R, GREEN, M. D, MACKENZIE, P. I, TEPHLY, T. R

“…Opioids are important drugs used as analgesics, antitussives, antidiarrheals, and in the therapy of myocardial infarctions, and as antagonists of opioid…”
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Folate and 10-formyltetrahydrofolate dehydrogenase (FDH) expression in the central nervous system of the mature rat by Neymeyer, Valerie, Tephly, Thomas R, Miller, Michael W

“…10-Formyltetrahydrofolate dehydrogenase (10-FTHFDH) is a folate-binding protein that is important in folate metabolism. In addition, 10-FTHFDH catalyzes the…”
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Immunohistochemical Localization of UDP-Glucuronosyltransferases in Rat Brain During Early Development by MARTINASEVIC, M. K, KING, C. D, RIOS, G. R, TEPHLY, T. R

“…Extrahepatic glucuronidation, such as that in the central nervous system (CNS), may play a very important role in xenobiotic disposition and may serve to…”
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Glucuronidation of Linoleic Acid Diols by Human Microsomal and Recombinant UDP-Glucuronosyltransferases: Identification of UGT2B7 as the Major Isoform Involved by Jude, Anthony R., Little, Joanna M., Czernik, Piotr J., Tephly, Thomas R., Grant, David F., Radominska-Pandya, Anna

“…Recent reports suggest that linoleic acid (LA) epoxides and diols are associated with important physiological, pharmacological, and pathological events in…”
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Glucuronidation of the Lung Carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by Rat UDP-Glucuronosyltransferase 2B1 by QING REN, MURPHY, S. E, DANNENBERG, A. J, PARK, J. Y, TEPHLY, T. R, LAZARUS, P

“…4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and its major metabolite, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), are potent lung carcinogens in…”
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Glucuronidation of Opioids, Carboxylic Acid-Containing Drugs, and Hydroxylated Xenobiotics Catalyzed by Expressed Monkey UDP-Glucuronosyltransferase 2B9 Protein by GREEN, M. D, BELANGER, G, HUM, D. W, BELANGER, A, TEPHLY, T. R

“…UDP-glucuronosyltransferase (UGT) 2B9, isolated from a cynomolgus monkey liver cDNA library, is 89% identical to human UGT2B7 in primary amino acid sequence,…”
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