Search Results - "Tephly, Linda A"

Nalp3 inflammasome is essential for the development of silicosis by Cassel, Suzanne L, Eisenbarth, Stephanie C, Iyer, Shankar S, Sadler, Jeffrey J, Colegio, Oscar R, Tephly, Linda A, Carter, A. Brent, Rothman, Paul B, Flavell, Richard A, Sutterwala, Fayyaz S

“…Inhalation of crystalline silica and asbestos is known to cause the progressive pulmonary fibrotic disorders silicosis and asbestosis, respectively. Although…”
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Constitutive NADPH oxidase and increased mitochondrial respiratory chain activity regulate chemokine gene expression by Tephly, Linda A, Carter, A Brent

“…Alveolar macrophages, which generate high levels of reactive oxygen species, especially O(2)(*-), are involved in the recruitment of neutrophils to sites of…”
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Oxysterols Inhibit Phosphatidylcholine Synthesis via ERK Docking and Phosphorylation of CTP:Phosphocholine Cytidylyltransferase by Agassandian, Marianna, Zhou, Jiming, Tephly, Linda A., Ryan, Alan J., Carter, A. Brent, Mallampalli, Rama K.

“…Surfactant deficiency contributes to acute lung injury and may result from the elaboration of bioactive lipids such as oxysterols. We observed that the…”
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Modulation of reactive oxygen species by Rac1 or catalase prevents asbestos-induced pulmonary fibrosis by Murthy, Shubha, Adamcakova-Dodd, Andrea, Perry, Sarah S, Tephly, Linda A, Keller, Richard M, Metwali, Nervana, Meyerholz, David K, Wang, Yongqiang, Glogauer, Michael, Thorne, Peter S, Carter, A Brent

“…The release of reactive oxygen species (ROS) and cytokines by alveolar macrophages has been demonstrated in asbestos-induced pulmonary fibrosis, but the…”
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Asbestos-induced MKP-3 expression augments TNF-alpha gene expression in human monocytes by Tephly, Linda A, Carter, A Brent

“…TNF-alpha is associated with the development of interstitial fibrosis. We have demonstrated that the p38 mitogen-activated protein (MAP) kinase regulates…”
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Differential expression and oxidation of MKP-1 modulates TNF-alpha gene expression by Tephly, Linda A, Carter, A Brent

“…Monocytic cells are integral in the pathogenesis of inflammatory disorders. We have shown previously that asbestos-induced p38 mitogen-activated protein (MAP)…”
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The Absence of Activator Protein 1-dependent Gene Expression in THP-1 Macrophages Stimulated with Phorbol Esters Is Due to Lack of p38 Mitogen-activated Protein Kinase Activation by Carter, A. Brent, Tephly, Linda A., Hunninghake, Gary W.

“…Activator protein 1 (AP-1) binds to the promoters of many genes involved in immune and inflammatory responses. We have previously shown that the p38…”
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Asbestos-Induced MKP-3 Expression Augments TNF-{alpha} Gene Expression in Human Monocytes by Tephly, Linda A, Carter, A. Brent

“…TNF-alpha is associated with the development of interstitial fibrosis. We have demonstrated that the p38 mitogen-activated protein (MAP) kinase regulates…”
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Both the NADPH oxidase and the mitochondrial respiratory chain regulate chemokine gene expression by Carter, A. Brent, Tephly, Linda A

“…Alveolar macrophages are involved in the pathogenesis of immune and inflammatory disorders of the lung. One hallmark of the cellular response to inflammation…”
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Differential Expression and Oxidation of MKP-1 Modulates TNF-{alpha} Gene Expression by Tephly, Linda A, Carter, A. Brent

“…Monocytic cells are integral in the pathogenesis of inflammatory disorders. We have shown previously that asbestos-induced p38 mitogen-activated protein (MAP)…”
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High Levels of Catalase and Glutathione Peroxidase Activity Dampen H2O2 Signaling in Human Alveolar Macrophages by Carter, A. Brent, Tephly, Linda A, Venkataraman, Sujatha, Oberley, Larry W, Zhang, Yuping, Buettner, Garry R, Spitz, Douglas R, Hunninghake, Gary W

“…Results are presented which support the hypothesis that adequate steady-state levels of hydrogen peroxide (H2O2) are required to overcome the effects of high…”
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15-Deoxy-Δ12,14-prostaglandin J2 Impairs Phosphatidylcholine Synthesis and Induces Nuclear Accumulation of Thiol-modified Cytidylyltransferase by Alan J. Ryan, Bill B. Chen, Prashanth R. Vennalaganti, Florita C. Henderson, Linda A. Tephly, A. Brent Carter, Rama K. Mallampalli

“…Synthesis of phosphatidylcholine, the major phospholipid of animal cell membranes, requires the key enzyme cytidylyltransferase (CCTα). Cysteine sulfhydryls…”
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15-deoxy-Delta12,14-prostaglandin J2 impairs phosphatidylcholine synthesis and induces nuclear accumulation of thiol-modified cytidylyltransferase by Ryan, Alan J, Chen, Bill B, Vennalaganti, Prashanth R, Henderson, Florita C, Tephly, Linda A, Carter, A Brent, Mallampalli, Rama K

“…Synthesis of phosphatidylcholine, the major phospholipid of animal cell membranes, requires the key enzyme cytidylyltransferase (CCTalpha). Cysteine…”
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15-Deoxy-Δ12,14-prostaglandin J2 Impairs Phosphatidylcholine Synthesis and Induces Nuclear Accumulation of Thiol-modified Cytidylyltransferase by Ryan, Alan J., Chen, Bill B., Vennalaganti, Prashanth R., Henderson, Florita C., Tephly, Linda A., Carter, A. Brent, Mallampalli, Rama K.

“…Synthesis of phosphatidylcholine, the major phospholipid of animal cell membranes, requires the key enzyme cytidylyltransferase (CCTα). Cysteine sulfhydryls…”
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High Levels of Catalase and Glutathione Peroxidase Activity Dampen H^sub 2^O^sub 2^ Signaling in Human Alveolar Macrophages by Carter, A Brent, Tephly, Linda A, Venkataraman, Sujatha, Oberley, Larry W

“…Results are presented which support the hypothesis that adequate steady-state levels of hydrogen peroxide (H2O2) are required to overcome the effects of high…”
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High Levels of Catalase and Glutathione Peroxidase Activity Dampen H 2 O 2 Signaling in Human Alveolar Macrophages by Carter, A. Brent, Tephly, Linda A., Venkataraman, Sujatha, Oberley, Larry W., Zhang, Yuping, Buettner, Garry R., Spitz, Douglas R., Hunninghake, Gary W.

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