Search Results - "Tenti, Giammarco"

Ruthenium(II)-Catalyzed Oxidative CH Alkenylations of Sulfonic Acids, Sulfonyl Chlorides and Sulfonamides by Ma, Wenbo, Mei, Ruhuai, Tenti, Giammarco, Ackermann, Lutz

“…Twofold CH functionalization of aromatic sulfonic acids was achieved with an in situ generated ruthenium(II) catalyst. The optimized cross‐dehydrogenative…”
Get full text

Antioxidant, Anti-inflammatory and Neuroprotective Profiles of Novel 1,4-Dihydropyridine Derivatives for the Treatment of Alzheimer’s Disease by Michalska, Patrycja, Mayo, Paloma, Fernández-Mendívil, Cristina, Tenti, Giammarco, Duarte, Pablo, Buendia, Izaskun, Ramos, María Teresa, López, Manuela G., Menéndez, J. Carlos, León, Rafael

“…Alzheimer’s disease is a chronic and irreversible pathological process that has become the most prevalent neurodegenerative disease. Currently, it is…”
Get full text

(E)-3-((2-Fluorophenyl)(hydroxy)methylene)imidazo[1,2-a]pyridin-2(3H)-one by Tenti, Giammarco, Cores, Ángel, Ramos, María Teresa, Menéndez, J. Carlos

“…Treatment of a N-2-pyridyl-β-ketoamide precursor with bromine afforded the first example of the 3-aryl(α-hydroxy)methylenelimidazo[1,2-a]pyridin-2(3H)-one…”
Get full text

Discovery of the first dual GSK3β inhibitor/Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer’s disease by Gameiro, Isabel, Michalska, Patrycja, Tenti, Giammarco, Cores, Ángel, Buendia, Izaskun, Rojo, Ana I., Georgakopoulos, Nikolaos D., Hernández-Guijo, Jesús M., Teresa Ramos, María, Wells, Geoffrey, López, Manuela G., Cuadrado, Antonio, Menéndez, J. Carlos, León, Rafael

“…The formation of neurofibrillary tangles (NFTs), oxidative stress and neuroinflammation have emerged as key targets for the treatment of Alzheimer’s disease…”
Get full text

Synthesis of 1,4-Diazepanes and Benzo[b][1,4]diazepines by a Domino Process Involving the In Situ Generation of an Aza-Nazarov Reagent by Maiti, Swarupananda, Leonardi, Marco, Cores, Ángel, Tenti, Giammarco, Ramos, M. Teresa, Villacampa, Mercedes, Menéndez, J. Carlos

“…A step- and atom-economical protocol allowing the synthesis of 1,4-diazepanes and also tetrahydro- and decahydro-1,5-benzodiazepines is described. The method…”
Get full text

Ruthenium(II)-Catalyzed Oxidative CH Alkenylations of Sulfonic Acids, Sulfonyl Chlorides and Sulfonamides by Ma, Wenbo, Mei, Ruhuai, Tenti, Giammarco, Ackermann, Lutz

“…Twofold CH functionalization of aromatic sulfonic acids was achieved with an insitu generated ruthenium(II) catalyst. The optimized cross-dehydrogenative…”
Get full text

New 5‑Unsubstituted Dihydropyridines with Improved CaV1.3 Selectivity as Potential Neuroprotective Agents against Ischemic Injury by Tenti, Giammarco, Parada, Esther, León, Rafael, Egea, Javier, Martínez-Revelles, Sonia, Briones, Ana María, Sridharan, Vellaisamy, López, Manuela G, Ramos, María Teresa, Menéndez, J. Carlos

“…C5-unsubstituted-C6-aryl-1,4-dihydropyridines were prepared by a CAN-catalyzed multicomponent reaction from chalcones, β-dicarbonyl compounds, and ammonium…”
Get full text

Aza‐CGP37157‐lipoic hybrids designed as novel Nrf2‐inducers and antioxidants exert neuroprotection against oxidative stress and show neuroinflammation inhibitory properties by Michalska, Patrycja, Tenti, Giammarco, Satriani, Michelle, Cores, Angel, Ramos, María Teresa, García, Antonio G., Menéndez, José Carlos, León, Rafael

“…Two multitarget hybrids, derived from an aza‐analogue of CGP37157, a mitochondrial Na+/Ca2+ exchanger antagonist, and lipoic acid were designed in order to…”
Get full text

A heavy metal- and oxidant-free, one-pot synthesis of pyridines and fused pyridines based on a Lewis acid-catalyzed multicomponent reaction by Raja, V P Alex, Tenti, Giammarco, Perumal, Subbu, Menéndez, J Carlos

“…The InCl3-catalyzed sequential multicomponent reaction between 2-furfurylamine, β-dicarbonyl compounds and α,β-unsaturated aldehydes in ethanol, followed by…”
Get more information

One-Pot Access to a Library of Structurally Diverse Nicotinamide Derivatives via a Three-Component Formal Aza [3 + 3] Cycloaddition by Tenti, Giammarco, Ramos, Ma Teresa, Menéndez, J. Carlos

“…The three-component formal [3 + 3] aza-annulation between chalcones, β-ketoamides, and ammonium acetate in the presence of CAN as a Lewis acid affords good to…”
Get full text

ITH14001, a CGP37157-Nimodipine Hybrid Designed to Regulate Calcium Homeostasis and Oxidative Stress, Exerts Neuroprotection in Cerebral Ischemia by Buendia, Izaskun, Tenti, Giammarco, Michalska, Patrycja, Méndez-López, Iago, Luengo, Enrique, Satriani, Michele, Padín-Nogueira, Fernando, López, Manuela G, Ramos, M. Teresa, García, Antonio G, Menéndez, J. Carlos, León, Rafael

“…During brain ischemia, oxygen and glucose deprivation induces calcium overload, extensive oxidative stress, neuroinflammation, and, finally, massive neuronal…”
Get full text

New 5-Unsubstituted Dihydropyridines with Improved Ca V 1.3 Selectivity as Potential Neuroprotective Agents against Ischemic Injury by Tenti, Giammarco, Parada, Esther, León, Rafael, Egea, Javier, Martínez-Revelles, Sonia, Briones, Ana María, Sridharan, Vellaisamy, López, Manuela G., Ramos, María Teresa, Menéndez, J. Carlos

Get full text

Addition to “ITH14001, a CGP37157-Nimodipine Hybrid Designed to Regulate Calcium Homeostasis and Oxidative Stress, Exerts Neuroprotection in Cerebral Ischemia” by Buendia, Izaskun, Tenti, Giammarco, Michalska, Patrycja, Méndez-López, Iago, Luengo, Enrique, Satriani, Michelle, Padín-Nogueira, Fernando, López, Manuela G, Ramos, M. Teresa, García, Antonio G, Menéndez, J. Carlos, León, Rafael

Get full text

Discovery of the first dual GSK3[beta] inhibitor/Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer's disease by Gameiro, Isabel, Michalska, Patrycja, Tenti, Giammarco, Cores, Ángel, Buendia, Izaskun, Rojo, Ana I, Georgakopoulos, Nikolaos D, Hernández-guijo, Jesús M, Teresa Ramos, María, Wells, Geoffrey, López, Manuela G, Cuadrado, Antonio, Menéndez, J Carlos, León, Rafael

“…The formation of neurofibrillary tangles (NFTs), oxidative stress and neuroinflammation have emerged as key targets for the treatment of Alzheimer's disease…”
Get full text