Search Results - "Tenorio, Connie A."

Alternative Folding Nuclei Definitions Facilitate the Evolution of a Symmetric Protein Fold from a Smaller Peptide Motif by Longo, Liam M., Lee, Jihun, Tenorio, Connie A., Blaber, Michael

“…Protein 3° structure symmetry is a defining feature of nearly one-third of protein folds and is generally thought to result from a combination of gene…”
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Functionalization of a symmetric protein scaffold: Redundant folding nuclei and alternative oligomeric folding pathways by Tenorio, Connie A., Parker, Joseph B., Blaber, Michael

“…Successful de novo protein design ideally targets specific folding kinetics, stability thermodynamics, and biochemical functionality, and the simultaneous…”
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The ubiquitous buried water in the beta‐trefoil architecture contributes to the folding nucleus and ~20% of the folding enthalpy by Parker, Joseph B., Tenorio, Connie A., Blaber, Michael

“…The beta‐trefoil protein architecture is characterized by three repeating “trefoil” motifs related by rotational symmetry and postulated to have evolved via…”
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Oligomerization of a symmetric β‐trefoil protein in response to folding nucleus perturbation by Tenorio, Connie A., Parker, Joseph B., Blaber, Michael

“…Gene duplication and fusion events in protein evolution are postulated to be responsible for the common protein folds exhibiting internal rotational symmetry…”
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Ab initio folding of a trefoil‐fold motif reveals structural similarity with a β‐propeller blade motif by Tenorio, Connie A., Longo, Liam M., Parker, Joseph B., Lee, Jihun, Blaber, Michael

“…Many protein architectures exhibit evidence of internal rotational symmetry postulated to be the result of gene duplication/fusion events involving a…”
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Investigating the dynamics and polyanion binding sites of fibroblast growth factor‐1 using hydrogen‐deuterium exchange mass spectrometry by Angalakurthi, Siva K., Tenorio, Connie A., Blaber, Michael, Middaugh, Charles Russell

“…In this study, we examined the local dynamics of acidic fibroblast growth factor (FGF‐1) as well as the binding sites of various polyanions including…”
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Folding nucleus structure persists in thermally‐aggregated FGF‐1 by Longo, Liam M., Gao, Yuan, Tenorio, Connie A., Wang, Gan, Paravastu, Anant K., Blaber, Michael

“…An efficient protein‐folding pathway leading to target structure, and the avoidance of aggregation, is essential to protein evolution and de novo design;…”
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A single aromatic core mutation converts a designed “primitive” protein from halophile to mesophile folding by Longo, Liam M., Tenorio, Connie A., Kumru, Ozan S., Middaugh, C. Russell, Blaber, Michael

“…The halophile environment has a number of compelling aspects with regard to the origin of structured polypeptides (i.e., proteogenesis) and, instead of a…”
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Engineering a Cysteine-Free Form of Human Fibroblast Growth Factor-1 for "Second Generation" Therapeutic Application by Xia, Xue, Kumru, Ozan S, Blaber, Sachiko I, Middaugh, C Russell, Li, Ling, Ornitz, David M, Sutherland, Mason A, Tenorio, Connie A, Blaber, Michael

“…Human fibroblast growth factor-1 (FGF-1) has broad therapeutic potential in regenerative medicine but has undesirable biophysical properties of low…”
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An S116R Phosphorylation Site Mutation in Human Fibroblast Growth Factor-1 Differentially Affects Mitogenic and Glucose-Lowering Activities by Xia, Xue, Kumru, Ozan S, Blaber, Sachiko I, Middaugh, C Russell, Li, Ling, Ornitz, David M, Suh, Jae Myoung, Atkins, Annette R, Downes, Michael, Evans, Ronald M, Tenorio, Connie A, Bienkiewicz, Ewa, Blaber, Michael

“…Fibroblast growth factor-1 (FGF-1), a potent human mitogen and insulin sensitizer, signals through both tyrosine kinase receptor-mediated autocrine/paracrine…”
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A bell-shaped dose–response of topical FGF-1 in accelerating dermal wound healing in aged female BALB/cByJ mice by Hagerott, Brooke N., Blumstein, Alli J., McGarry, Lauren E., Cohen, Hannah M., Tenorio, Connie A., Powell, Brett D., Nagy, Tamas, Blaber, Michael

“…The objective of this study was to characterize the therapeutic dose–response characteristics for topical FGF-1 in the full-thickness dermal healing of aged…”
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