Search Results - "Tenney, Alan P."

A cell type-aware framework for nominating non-coding variants in Mendelian regulatory disorders by Lee, Arthur S., Ayers, Lauren J., Kosicki, Michael, Chan, Wai-Man, Fozo, Lydia N., Pratt, Brandon M., Collins, Thomas E., Zhao, Boxun, Rose, Matthew F., Sanchis-Juan, Alba, Fu, Jack M., Wong, Isaac, Zhao, Xuefang, Tenney, Alan P., Lee, Cassia, Laricchia, Kristen M., Barry, Brenda J., Bradford, Victoria R., Jurgens, Julie A., England, Eleina M., Lek, Monkol, MacArthur, Daniel G., Lee, Eunjung Alice, Talkowski, Michael E., Brand, Harrison, Pennacchio, Len A., Engle, Elizabeth C.

“…Unsolved Mendelian cases often lack obvious pathogenic coding variants, suggesting potential non-coding etiologies. Here, we present a single cell multi-omic…”
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Etv1 Controls the Establishment of Non-overlapping Motor Innervation of Neighboring Facial Muscles during Development by Tenney, Alan P., Livet, Jean, Belton, Timothy, Prochazkova, Michaela, Pearson, Erica M., Whitman, Mary C., Kulkarni, Ashok B., Engle, Elizabeth C., Henderson, Christopher E.

“…The somatotopic motor-neuron projections onto their cognate target muscles are essential for coordinated movement, but how that occurs for facial motor…”
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The HSPGs Syndecan and Dallylike Bind the Receptor Phosphatase LAR and Exert Distinct Effects on Synaptic Development by Johnson, Karl G., Tenney, Alan P., Ghose, Aurnab, Duckworth, April M., Higashi, Misao E., Parfitt, Karen, Marcu, Oana, Heslip, Timothy R., Marsh, J. Lawrence, Schwarz, Thomas L., Flanagan, John G., Van Vactor, David

“…The formation and plasticity of synaptic connections rely on regulatory interactions between pre- and postsynaptic cells. We show that the Drosophila heparan…”
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PTPσ Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration by Shen, Yingjie, Tenney, Alan P., Busch, Sarah A., Horn, Kevin P., Cuascut, Fernando X., Liu, Kai, He, Zhigang, Silver, Jerry, Flanagan, John G.

“…Chondroitin sulfate proteoglycans (CSPGs) present a barrier to axon regeneration. However, no specific receptor for the inhibitory effect of CSPGs has been…”
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Proteoglycan-Specific Molecular Switch for RPTPσ Clustering and Neuronal Extension by Coles, Charlotte H., Shen, Yingjie, Tenney, Alan P., Siebold, Christian, Sutton, Geoffrey C., Lu, Weixian, Gallagher, John T., Jones, E. Yvonne, Flanagan, John G., Aricescu, A. Radu

“…Heparan and chondroitin sulfate proteoglycans (HSPGs and CSPGs, respectively) regulate numerous cell surface signaling events, with typically opposite effects…”
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Loss of CXCR4/CXCL12 Signaling Causes Oculomotor Nerve Misrouting and Development of Motor Trigeminal to Oculomotor Synkinesis by Whitman, Mary C, Nguyen, Elaine H, Bell, Jessica L, Tenney, Alan P, Gelber, Alon, Engle, Elizabeth C

“…Proper control of eye movements is critical to vision, but relatively little is known about the molecular mechanisms that regulate development and axon…”
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Noncoding variants alter GATA2 expression in rhombomere 4 motor neurons and cause dominant hereditary congenital facial paresis by Tenney, Alan P., Di Gioia, Silvio Alessandro, Webb, Bryn D., Chan, Wai-Man, de Boer, Elke, Garnai, Sarah J., Barry, Brenda J., Ray, Tammy, Kosicki, Michael, Robson, Caroline D., Zhang, Zhongyang, Collins, Thomas E., Gelber, Alon, Pratt, Brandon M., Fujiwara, Yuko, Varshney, Arushi, Lek, Monkol, Warburton, Peter E., Van Ryzin, Carol, Lehky, Tanya J., Zalewski, Christopher, King, Kelly A., Brewer, Carmen C., Thurm, Audrey, Snow, Joseph, Facio, Flavia M., Narisu, Narisu, Bonnycastle, Lori L., Swift, Amy, Chines, Peter S., Bell, Jessica L., Mohan, Suresh, Whitman, Mary C., Staffieri, Sandra E., Elder, James E., Demer, Joseph L., Torres, Alcy, Rachid, Elza, Al-Haddad, Christiane, Boustany, Rose-Mary, Mackey, David A., Brady, Angela F., Fenollar-Cortés, María, Fradin, Melanie, Kleefstra, Tjitske, Padberg, George W., Raskin, Salmo, Sato, Mario Teruo, Orkin, Stuart H., Parker, Stephen C. J., Hadlock, Tessa A., Vissers, Lisenka E. L. M., van Bokhoven, Hans, Jabs, Ethylin Wang, Collins, Francis S., Pennacchio, Len A., Manoli, Irini, Engle, Elizabeth C.

“…Hereditary congenital facial paresis type 1 (HCFP1) is an autosomal dominant disorder of absent or limited facial movement that maps to chromosome 3q21-q22 and…”
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Mutant α2-chimaerin signals via bidirectional ephrin pathways in Duane retraction syndrome by Nugent, Alicia A, Park, Jong G, Wei, Yan, Tenney, Alan P, Gilette, Nicole M, DeLisle, Michelle M, Chan, Wai-Man, Cheng, Long, Engle, Elizabeth C

“…Duane retraction syndrome (DRS) is the most common form of congenital paralytic strabismus in humans and can result from α2-chimaerin (CHN1) missense…”
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Mutant α2-chimaerin signals via bidirectional ephrin pathways in Duane retraction syndrome by Nugent, Alicia A., Park, Jong G., Wei, Yan, Tenney, Alan P., Gilette, Nicole M., DeLisle, Michelle M., Chan, Wai-Man, Cheng, Long, Engle, Elizabeth C.

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Mutant [alpha]2-chimaerin signals via bidirectional ephrin pathways in Duane retraction syndrome by Nugen, Alicia A, Park, Jong G, Wei, Yan, Tenney, Alan P, Gilette, Nicole M, DeLisle, Michelle M, Chan, Wai-Man, Cheng, Long, Engle, Elizabeth C

“…Duane retraction syndrome (DRS) is the most common form of congenital paralytic strabismus in humans and can result from [alpha]2-chimaerin (CHN1) missense…”
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Proteoglycan-Specific Molecular Switch for RPTP[sigma] Clustering and Neuronal Extension by Coles, Charlotte H, Shen, Yingjie, Tenney, Alan P, Siebold, Christian, Sutton, Geoffrey C, Lu, Weixian, Gallagher, John T, Jones, E Yvonne, Flanagan, John G, A. Radu Aricescu

“…As axons extend outward, whether in the course of normal development or in regenerating after damage, they encounter an environment that includes…”
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PTP[sigma] Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration by Shen, Yingjie, Tenney, Alan P, Busch, Sarah A, Horn, Kevin P, Cuascut, Fernando X, Liu, Kai, He, Zhigang, Silver, Jerry, Flanagan, John G

“…Chondroitin sulfate proteoglycans (CSPGs) present a barrier to axon regeneration. However, no specific receptor for the inhibitory effect of CSPGs has been…”
Get full text

PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration by Shen, Yingjie, Tenney, Alan P, Busch, Sarah A, Horn, Kevin P, Cuascut, Fernando X, Liu, Kai, He, Zhigang, Silver, Jerry, Flanagan, John G

“…Chondroitin sulfate proteoglycans (CSPGs) present a barrier to axon regeneration. However, no specific receptor for the inhibitory effect of CSPGs has been…”
Get full text