Search Results - "Tenner, J."

Complement-Mediated Events in Alzheimer's Disease: Mechanisms and Potential Therapeutic Targets by Tenner, Andrea J

“…An estimated 5.7 million Americans suffer from Alzheimer's disease in the United States, with no disease-modifying treatments to prevent or treat cognitive…”
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Therapeutic Targeting of the Complement System: From Rare Diseases to Pandemics by Garred, Peter, Tenner, Andrea J, Mollnes, Tom E

“…The complement system was discovered at the end of the 19th century as a heat-labile plasma component that "complemented" the antibodies in killing microbes,…”
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The good, the bad, and the opportunities of the complement system in neurodegenerative disease by Schartz, Nicole D, Tenner, Andrea J

“…The complement cascade is a critical effector mechanism of the innate immune system that contributes to the rapid clearance of pathogens and dead or dying…”
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New tricks for an ancient system: Physiological and pathological roles of complement in the CNS by Tenner, Andrea J., Stevens, Beth, Woodruff, Trent M.

“…•Complement has critical functional roles in embryonic brain development.•C1, C4, C2, C3 and CR3 are critical in synaptic refinement during brain…”
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Elimination of Microglia Improves Functional Outcomes Following Extensive Neuronal Loss in the Hippocampus by Rice, Rachel A, Spangenberg, Elizabeth E, Yamate-Morgan, Hana, Lee, Rafael J, Arora, Rajan P S, Hernandez, Michael X, Tenner, Andrea J, West, Brian L, Green, Kim N

“…With severe injury or disease, microglia become chronically activated and damage the local brain environment, likely contributing to cognitive decline. We…”
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Complement Nomenclature-Deconvoluted by Bohlson, Suzanne S, Garred, Peter, Kemper, Claudia, Tenner, Andrea J

“…In 2014, specific recommendations for complement nomenclature were presented by the complement field. There remained some unresolved designations and new areas…”
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Complement protein C1q directs macrophage polarization and limits inflammasome activity during the uptake of apoptotic cells by Benoit, Marie E, Clarke, Elizabeth V, Morgado, Pedro, Fraser, Deborah A, Tenner, Andrea J

“…Deficiency in C1q, the recognition component of the classical complement cascade and a pattern recognition receptor involved in apoptotic cell clearance, leads…”
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A dramatic increase of C1q protein in the CNS during normal aging by Stephan, Alexander H, Madison, Daniel V, Mateos, José María, Fraser, Deborah A, Lovelett, Emilie A, Coutellier, Laurence, Kim, Leo, Tsai, Hui-Hsin, Huang, Eric J, Rowitch, David H, Berns, Dominic S, Tenner, Andrea J, Shamloo, Mehrdad, Barres, Ben A

“…The decline of cognitive function has emerged as one of the greatest health threats of old age. Age-related cognitive decline is caused by an impacted neuronal…”
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Sialic acid on the neuronal glycocalyx prevents complement C1 binding and complement receptor-3-mediated removal by microglia by Linnartz, Bettina, Kopatz, Jens, Tenner, Andrea J, Neumann, Harald

“…Microglial cells are professional phagocytes of the CNS responsible for clearance of unwanted structures. Neuronal processes are marked by complement C1 before…”
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The role of the anaphylatoxins in health and disease by Klos, Andreas, Tenner, Andrea J., Johswich, Kay-Ole, Ager, Rahasson R., Reis, Edimara S., Köhl, Jörg

“…The anaphylatoxin (AT) C3a, C5a and C5a-desArg are generally considered pro-inflammatory polypeptides generated after proteolytic cleavage of C3 and C5 in…”
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C1q enhances microglial clearance of apoptotic neurons and neuronal blebs, and modulates subsequent inflammatory cytokine production by Fraser, Deborah A, Pisalyaput, Karntipa, Tenner, Andrea J

“…J. Neurochem. (2010) 112, 733-743. The expression of C1q, a recognition molecule of the complement system, is up-regulated following neuronal injury and is…”
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Glia-Selective Deletion of Complement C1q Prevents Radiation-Induced Cognitive Deficits and Neuroinflammation by Markarian, Mineh, Krattli, Jr, Robert P, Baddour, Jabra D, Alikhani, Leila, Giedzinski, Erich, Usmani, Manal T, Agrawal, Anshu, Baulch, Janet E, Tenner, Andrea J, Acharya, Munjal M

“…The adverse neurocognitive sequelae following clinical radiotherapy (RT) for central nervous system (CNS) malignancies are often long-lasting without any…”
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Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer’s disease by Forner, Stefania, Kawauchi, Shimako, Balderrama-Gutierrez, Gabriela, Kramár, Enikö A., Matheos, Dina P., Phan, Jimmy, Javonillo, Dominic I., Tran, Kristine M., Hingco, Edna, da Cunha, Celia, Rezaie, Narges, Alcantara, Joshua A., Baglietto-Vargas, David, Jansen, Camden, Neumann, Jonathan, Wood, Marcelo A., MacGregor, Grant R., Mortazavi, Ali, Tenner, Andrea J., LaFerla, Frank M., Green, Kim N.

“…Mouse models of human diseases are invaluable tools for studying pathogenic mechanisms and testing interventions and therapeutics. For disorders such as…”
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Oxygen isotope systematics of chondrule phenocrysts from the CO3.0 chondrite Yamato 81020: Evidence for two distinct oxygen isotope reservoirs by Tenner, Travis J., Ushikubo, Takayuki, Kurahashi, Erika, Kita, Noriko T., Nagahara, Hiroko

“…High-precision oxygen three-isotope measurements of olivine and pyroxene were performed on 33 chondrules in the Yamato 81020 CO3.0 chondrite by secondary ion…”
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Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study by Cribbs, David H, Berchtold, Nicole C, Perreau, Victoria, Coleman, Paul D, Rogers, Joseph, Tenner, Andrea J, Cotman, Carl W

“…This study undertakes a systematic and comprehensive analysis of brain gene expression profiles of immune/inflammation-related genes in aging and Alzheimer's…”
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Correlated isotopic and chemical evidence for condensation origins of olivine in comet 81P/Wild 2 and in AOAs from CV and CO chondrites by Fukuda, Kohei, Brownlee, Donald E., Joswiak, David J., Tenner, Travis J., Kimura, Makoto, Kita, Noriko T.

“…Magnesium stable isotope ratios and minor element abundances of five olivine particles from comet 81P/Wild 2 were examined by secondary ion mass spectrometry…”
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Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer’s disease-like pathology by Baglietto-Vargas, David, Forner, Stefania, Cai, Lena, Martini, Alessandra C., Trujillo-Estrada, Laura, Swarup, Vivek, Nguyen, Marie Minh Thu, Do Huynh, Kelly, Javonillo, Dominic I., Tran, Kristine Minh, Phan, Jimmy, Jiang, Shan, Kramár, Enikö A., Nuñez-Diaz, Cristina, Balderrama-Gutierrez, Gabriela, Garcia, Franklin, Childs, Jessica, Rodriguez-Ortiz, Carlos J., Garcia-Leon, Juan Antonio, Kitazawa, Masashi, Shahnawaz, Mohammad, Matheos, Dina P., Ma, Xinyi, Da Cunha, Celia, Walls, Ken C., Ager, Rahasson R., Soto, Claudio, Gutierrez, Antonia, Moreno-Gonzalez, Ines, Mortazavi, Ali, Tenner, Andrea J., MacGregor, Grant R., Wood, Marcelo, Green, Kim N., LaFerla, Frank M.

“…The majority of Alzheimer’s disease (AD) cases are late-onset and occur sporadically, however most mouse models of the disease harbor pathogenic mutations,…”
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Systematic Phenotyping and Characterization of the 3xTg-AD Mouse Model of Alzheimer's Disease by Javonillo, Dominic I, Tran, Kristine M, Phan, Jimmy, Hingco, Edna, Kramár, Enikö A, da Cunha, Celia, Forner, Stefania, Kawauchi, Shimako, Milinkeviciute, Giedre, Gomez-Arboledas, Angela, Neumann, Jonathan, Banh, Crystal E, Huynh, Michelle, Matheos, Dina P, Rezaie, Narges, Alcantara, Joshua A, Mortazavi, Ali, Wood, Marcelo A, Tenner, Andrea J, MacGregor, Grant R, Green, Kim N, LaFerla, Frank M

“…Animal models of disease are valuable resources for investigating pathogenic mechanisms and potential therapeutic interventions. However, for complex disorders…”
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C5aR1 antagonism suppresses inflammatory glial responses and alters cellular signaling in an Alzheimer’s disease mouse model by Schartz, Nicole D., Liang, Heidi Y., Carvalho, Klebea, Chu, Shu-Hui, Mendoza-Arvilla, Adrian, Petrisko, Tiffany J., Gomez-Arboledas, Angela, Mortazavi, Ali, Tenner, Andrea J.

“…Alzheimer’s disease (AD) is the leading cause of dementia in older adults, and the need for effective, sustainable therapeutic targets is imperative. The…”
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Oxygen isotope characteristics of chondrules from the Yamato‐82094 ungrouped carbonaceous chondrite: Further evidence for common O‐isotope environments sampled among carbonaceous chondrites by Tenner, T. J., Kimura, M., Kita, N. T.

“…High‐precision secondary ion mass spectrometry (SIMS) was employed to investigate oxygen three isotopes of phenocrysts in 35 chondrules from the Yamato (Y)…”
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