Search Results - "Tenhunen, Jyrki J"

HMGB1 is secreted by immunostimulated enterocytes and contributes to cytomix-induced hyperpermeability of Caco-2 monolayers by Liu, Shiguang, Stolz, Donna B, Sappington, Penny L, Macias, Carlos A, Killeen, Meaghan E, Tenhunen, Jyrki J, Delude, Russell L, Fink, Mitchell P

“…High-mobility group box 1 (HMGB1), a cytokine-like proinflammatory protein, is secreted by activated macrophages and released by necrotic cells. We…”
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Usefulness of suPAR as a biological marker in patients with systemic inflammation or infection: a systematic review by Backes, Yara, van der Sluijs, Koenraad F., Mackie, David P., Tacke, Frank, Koch, Alexander, Tenhunen, Jyrki J., Schultz, Marcus J.

“…Purpose Systemic levels of soluble urokinase-type plasminogen activator receptor (suPAR) positively correlate with the activation level of the immune system…”
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Increasing abdominal pressure with and without PEEP: effects on intra-peritoneal, intra-organ and intra-vascular pressures by Jakob, Stephan M, Knuesel, Rafael, Tenhunen, Jyrki J, Pradl, Richard, Takala, Jukka

“…Intra-organ and intra-vascular pressures can be used to estimate intra-abdominal pressure. The aim of this prospective, interventional study was to assess the…”
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Early non-invasive cardiac output monitoring in hemodynamically unstable intensive care patients: a multi-center randomized controlled trial by Takala, Jukka, Ruokonen, Esko, Tenhunen, Jyrki J, Parviainen, Ilkka, Jakob, Stephan M

“…Acute hemodynamic instability increases morbidity and mortality. We investigated whether early non-invasive cardiac output monitoring enhances hemodynamic…”
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Glucose, lactate, and pyruvate response in an experimental model of microvascular flap ischemia and reperfusion: A microdialysis study by Setälä, Leena P., Korvenoja, E. Maj-lén, Härmä, Markku A., Alhava, Esko M., Uusaro, Ari V., Tenhunen, Jyrki J.

“…Early diagnosis of postoperative perfusion failure is essential in microsurgical tissue transfer. In order to determine if microdialysis could be used in…”
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In Death, Truth Lies: Why Do Patients with Sepsis Die? by Tenhunen, Jyrki J.

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Bull’s eye missed by the magic bullet: Preclinical investigations, publication bias, and promising new interventions by Tenhunen, Jyrki J

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The Effects of Vasopressin on Systemic and Splanchnic Hemodynamics and Metabolism in Endotoxin Shock by Martikainen, Tero J., Tenhunen, Jyrki J., Uusaro, Ari, Ruokonen, Esko

“…We compared the effects of vasopressin and norepinephrine on systemic and splanchnic circulation and metabolism in endotoxin shock in pigs. Twenty-one pigs…”
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Sympathetic innervation does not contribute to glycerol release in ischemic flaps by Raittinen, Lassi P., Berg, Leena, Nunes, Silvia, Ahonen, Heikki, Parviainen, Ilkka, Laranne, Jussi, Tenhunen, Jyrki J.

“…Abstract Background. Extracellular glycerol as detected by microdialysis has been used as a surrogate marker for (ischemic) tissue damage and cellular membrane…”
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Survival in a rat model of lethal hemorrhagic shock is prolonged following resuscitation with a small volume of a solution containing a Drag-reducing polymer derived from aloe vera by MACIAS, Carlos A, KAMENEVA, Marina V, TENHUNEN, Jyrki J, PUYANA, Juan-Carlos, FINK, Mitchell P

“…Drag-reducing polymers (DRP) increase tissue perfusion at constant driving pressure. We sought to evaluate the effects of small-volume resuscitation with a…”
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Apparent Heterogeneity of Regional Blood Flow and Metabolic Changes Within Splanchnic Tissues During Experimental Endotoxin Shock by Tenhunen, Jyrki J., Uusaro, Ari, Kärjä, Vesa, Oksala, Niku, Jakob, Stephan M., Ruokonen, Esko

“…We conducted a randomized, controlled experiment of prolonged lethal endotoxin shock in pigs aiming at 1) simultaneously measuring perfusion at different parts…”
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Lipopolysaccharide preconditioning attenuates metabolic alteration induced by endotoxin shock: tissue-specific monitoring by microdialysis by Tenhunen, Jyrki J

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Hepatosplanchnic blood flow control and oxygen extraction are modified by the underlying mechanism of impaired perfusion by Bracht, Hendrik, Takala, Jukka, Tenhunen, Jyrki J, Brander, Lukas, Knuesel, Rafael, Merasto-Minkkinen, Minna, Jakob, Stephan M

“…OBJECTIVE:To assess the effects of low hepatosplanchnic blood flow on regional blood flow control and oxygenation. DESIGN:Three randomized, controlled animal…”
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Gut luminal lactate release during gradual intestinal ischemia by TENHUNEN, Jyrki J, JAKOB, Stephan M, TAKALA, Jukka A

“…Gut ischemia induced by occlusion of the superior mesenteric artery (SMA) results in release of lactate into the gut lumen. We studied the threshold of SMA…”
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Intestinal luminal lactate in shock-marker for altered epithelial cellular metabolism? by Tenhunen, Jyrki J., Takala, Jukka

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Splanchnic vasoregulation during mesenteric ischemia and reperfusion in pigs by JAKOB, Stephan M, TENHUNEN, Jyrki J, HEINO, Autero, PRADL, Richard, ALHAVA, Esko, TAKALA, Jukka

“…We evaluated the hepatic arterial buffer response (HABR) to portal vein (PV) occlusion during 2 h of reduced superior mesenteric arterial blood flow (median 2…”
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Gastric mucosal systemic partial pressure of carbon dioxide (PCO2) gradient in experimental endotoxin shock in swine: comparison of two methods by J.TENHUNEN, Jyrki, UUSARO, Ari, RUOKONEN, Esko

“…Clinically applicable methods for continuous monitoring of visceral perfusion/metabolism do not exist. Gastric mucosal end-tidal partial pressure of carbon…”
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FLUID RESUSCITATION WITH ETHYL PYRUVATE SOLUTION RESTORES SPLANCHNIC PERFUSION BETTER THAN RINGERS ACETATE ALONE: 89 by Tenhunen, Jyrki J, Fink, Mitchell P, Ruokonen, Esko, Parviainen, Ilkka

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Epinephrine induces tissue perfusion deficit in porcine endotoxin shock: evaluation by regional CO(2) content gradients and lactate-to-pyruvate ratios by Martikainen, Tero J, Tenhunen, Jyrki J, Giovannini, Ivo, Uusaro, Ari, Ruokonen, Esko

“…Epinephrine is widely used as a vasoconstrictor or inotrope in shock, although it may typically induce or augment lactic acidosis. Ongoing debate addresses the…”
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Intestinal Luminal Microdialysis: A new approach to assess Gut mucosal ischemia by TENHUNEN, J. J, KOSUNEN, H, ALHAVA, E, TUOMISTO, L, TAKALA, J. A

“…The authors developed a microdialysis method for sampling lactate from the gut lumen to evaluate the metabolic state of the intestinal mucosa. The aim of the…”
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