Search Results - "Tenen, D.G."

The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter by PAHL, H. L, SCHEIBE, R. J, DONG-ER ZHANG, HUI-MIN CHEN, GALSON, D. L, MAKI, R. A, TENEN, D. G

“…The myeloid integrin CD11b is expressed selectively on the surface of mature monocytes, macrophages, granulocytes, and natural killer cells. Tissue-specific…”
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The Sp1 transcription factor binds the CD11b promoter specifically in myeloid cells in vivo and is essential for myeloid-specific promoter activity by Chen, H M, Pahl, H L, Scheibe, R J, Zhang, D E, Tenen, D G

“…The myeloid integrin CD11b is expressed selectively on the surface of mature macrophages, monocytes, neutrophils, and natural killer cells. Lineage-specific…”
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Sp1 is a critical factor for the monocytic specific expression of human CD14 by Zhang, D E, Hetherington, C J, Tan, S, Dziennis, S E, Gonzalez, D A, Chen, H M, Tenen, D G

“…CD14 is a membrane glycoprotein expressed specifically on monocytes and macrophages, and its expression is markedly increased during the process of monocyte…”
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NF-κB/STAT5/miR-155 network targets PU.1 in FLT3-ITD-driven acute myeloid leukemia by Gerloff, D, Grundler, R, Wurm, A A, Bräuer-Hartmann, D, Katzerke, C, Hartmann, J-U, Madan, V, Müller-Tidow, C, Duyster, J, Tenen, D G, Niederwieser, D, Behre, G

“…Almost 30% of all acute myeloid leukemias (AML) are associated with an internal tandem duplication (ITD) in the juxtamembrane domain of FMS-like tyrosine…”
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SALL4 is a new target in endometrial cancer by Li, A, Jiao, Y, Yong, K J, Wang, F, Gao, C, Yan, B, Srivastava, S, Lim, G S D, Tang, P, Yang, H, Tenen, D G, Chai, L

“…Aggressive cancers and embryonic stem (ES) cells share a common gene expression signature. Identifying the key factors/pathway(s) within this ES signature…”
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Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding by Ptasinska, A, Assi, S A, Mannari, D, James, S R, Williamson, D, Dunne, J, Hoogenkamp, M, Wu, M, Care, M, McNeill, H, Cauchy, P, Cullen, M, Tooze, R M, Tenen, D G, Young, B D, Cockerill, P N, Westhead, D R, Heidenreich, O, Bonifer, C

“…The t(8;21) translocation fuses the DNA-binding domain of the hematopoietic master regulator RUNX1 to the ETO protein. The resultant RUNX1/ETO fusion protein…”
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Core-binding factor leukemia hijacks the T-cell–prone PU.1 antisense promoter by van der Kouwe, E., Heller, G., Czibere, A., Pulikkan, J.A., Agreiter, C., Castilla, L.H., Delwel, R., Di Ruscio, A., Ebralidze, A.K., Forte, M., Grebien, F., Heyes, E., Kazianka, L., Klinger, J., Kornauth, C., Le, T., Lind, K., Barbosa, I.A.M., Pemovska, T., Pichler, A., Schmolke, A.-S., Schweicker, C.M., Sill, H., Sperr, W.R., Spittler, A., Surapally, S., Trinh, B.Q., Valent, P., Vanura, K., Welner, R.S., Zuber, J., Tenen, D.G., Staber, P.B.

“…The blood system serves as a key model for cell differentiation and cancer. It is orchestrated by precise spatiotemporal expression of crucial transcription…”
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Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation by Iwasaki, Hiromi, Somoza, Chamorro, Shigematsu, Hirokazu, Duprez, Estelle A., Iwasaki-Arai, Junko, Mizuno, Shin-ichi, Arinobu, Yojiro, Geary, Kristin, Zhang, Pu, Dayaram, Tajhal, Fenyus, Maris L., Elf, Shannon, Chan, Susan, Kastner, Philippe, Huettner, Claudia S., Murray, Richard, Tenen, Daniel G., Akashi, Koichi

“…The PU.1 transcription factor is a key regulator of hematopoietic development, but its role at each hematopoietic stage remains unclear. In particular, the…”
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Overexpression of TRIB2 in human lung cancers contributes to tumorigenesis through downregulation of C EBPα by Grandinetti, K B, Stevens, T A, Ha, S, Salamone, R J, Walker, J R, Zhang, J, Agarwalla, S, Tenen, D G, Peters, E C, Reddy, V A

“…Lung cancer is the most common cause of cancer-related mortality worldwide. Here, we report elevated expression of tribbles homolog 2 (TRIB2) in primary human…”
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PML-RARα initiates leukemia by conferring properties of self-renewal to committed promyelocytic progenitors by Wojiski, S, Guibal, F C, Kindler, T, Lee, B H, Jesneck, J L, Fabian, A, Tenen, D G, Gilliland, D G

“…Acute promyelocytic leukemia (APL) is characterized by hyperproliferation of promyelocytes, progenitors that are committed to terminal differentiation into…”
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PU.1 is essential for MLL leukemia partially via crosstalk with the MEIS/HOX pathway by Zhou, J, Wu, J, Li, B, Liu, D, Yu, J, Yan, X, Zheng, S, Wang, J, Zhang, L, Zhang, L, He, F, Li, Q, Chen, A, Zhang, Y, Zhao, X, Guan, Y, Zhao, X, Yan, J, Ni, J, Nobrega, M A, Löwenberg, B, Delwel, R, Valk, P J M, Kumar, A, Xie, L, Tenen, D G, Huang, G, Wang, Q-f

“…Mixed lineage leukemia (MLL) fusion proteins directly activate the expression of key downstream genes such as MEIS1 , HOXA9 to drive an aggressive form of…”
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Functional characterization of the promoter for the gene encoding human eosinophil peroxidase by YAMAGUCHI, Y, DONG-ER ZHANG, SUN, Z, ALBEE, E. A, NAGATA, S, TENEN, D. G, ACKERMANS, S. J

“…The molecular basis for commitment of progenitors to the eosinophil lineage and mechanisms by which eosinophil-specific genes are expressed and regulated…”
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Elevated PIN1 expression by C EBPα-p30 blocks C EBPα-induced granulocytic differentiation through c-Jun in AML by Pulikkan, J A, Dengler, V, Peer Zada, A A, Kawasaki, A, Geletu, M, Pasalic, Z, Bohlander, S K, Ryo, A, Tenen, D G, Behre, G

“…The transcription factor CCAAT enhancer-binding protein α (C/EBPα) has an important role in granulopoiesis. The tumor suppressor function of C/EBPα is shown by…”
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C/EBPβ promotes BCR–ABL-mediated myeloid expansion and leukemic stem cell exhaustion by Hayashi, Y, Hirai, H, Kamio, N, Yao, H, Yoshioka, S, Miura, Y, Ashihara, E, Fujiyama, Y, Tenen, D G, Maekawa, T

“…The BCR–ABL fusion oncoprotein accelerates differentiation and proliferation of myeloid cells during the chronic phase of chronic myeloid leukemia (CP-CML)…”
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PU.1 induces apoptosis in myeloma cells through direct transactivation of TRAIL by Ueno, S, Tatetsu, H, Hata, H, Iino, T, Niiro, H, Akashi, K, Tenen, D G, Mitsuya, H, Okuno, Y

“…We earlier reported that PU.1 was downregulated in myeloma cell lines and myeloma cells in a subset of myeloma patients, and that conditional PU.1 expression…”
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Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 14 by Mastrianni, D M, Eddy, R L, Rosenberg, H F, Corrette, S E, Shows, T B, Tenen, D G, Ackerman, S J

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Overcoming limitations of the mRNA differential display technique by Sompayrac, L, Jane, S, Burn, T.C, Tenen, D.G, Danna, K.J

“…Differential mRNA display (DD) is potentially a powerful method for identifying genes that are over- or under-expressed in one cell type relative to another…”
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Molecular Cloning of the Human Eosinophil-Derived Neurotoxin: A Member of the Ribonuclease Gene Family by Rosenberg, Helene F., Tenen, Daniel G., Ackerman, Steven J.

“…We have isolated a 725-base-pair cDNA clone for human eosinophil-derived neurotoxin (EDN). EDN is a distinct cationic protein of the eosinophil's large…”
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Structural analysis of the CD11b gene and phylogenetic analysis of the [alpha]-integrin gene family demonstrate remarkable conservation of genomic organization and suggest early diversification during evolution by Fleming, J.C., Gonzalez, D.A., Tenen, D.G., Pahl, H.L., Smith, T.F.

“…CD11b is a member of the [beta]2 subfamily of the human leukocyte integrins. Its expression is limited to mature myeloid and NK cells and is up-regulated…”
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Characterization of a distinct binding site for the prokaryotic chaperone, GroEL, on a human granulocyte ribonuclease by ROSENBERG, H. F, ACKERMAN, S. J, TENEN, D. G

“…Although ribonucleases fold into correct tertiary conformation in vitro guided solely by information contained in the primary amino acid sequence (Sela, M.,…”
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