Search Results - "Tendyke, Karen"

Apratoxin A Shows Novel Pancreas-Targeting Activity through the Binding of Sec 61 by Huang, Kuan-Chun, Chen, Zhihong, Jiang, Yimin, Akare, Sandeep, Kolber-Simonds, Donna, Condon, Krista, Agoulnik, Sergei, Tendyke, Karen, Shen, Yongchun, Wu, Kuo-Ming, Mathieu, Steven, Choi, Hyeong-Wook, Zhu, Xiaojie, Shimizu, Hajime, Kotake, Yoshihiko, Gerwick, William H, Uenaka, Toshimitsu, Woodall-Jappe, Mary, Nomoto, Kenichi

“…Apratoxin A is a natural product with potent antiproliferative activity against many human cancer cell lines. However, we and other investigators observed that…”
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High-Throughput Assay Development for Cystine-Glutamate Antiporter (xc-) Highlights Faster Cystine Uptake than Glutamate Release in Glioma Cells by Thomas, Ajit G, Sattler, Rita, Tendyke, Karen, Loiacono, Kara A, Hansen, Hans, Sahni, Vishal, Hashizume, Yutaka, Rojas, Camilo, Slusher, Barbara S

“…The cystine-glutamate antiporter (system xc-) is a Na+-independent amino acid transporter that exchanges extracellular cystine for intracellular glutamate. It…”
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Induction of morphological and biochemical apoptosis following prolonged mitotic blockage by halichondrin B macrocyclic ketone analog E7389 by KUZNETSOV, Galina, TOWLE, Murray J, HONGSHENG CHENG, KAWAMURA, Takanori, TENDYKE, Karen, LIU, Diana, KISHI, Yoshito, YU, Melvin J, LITTLEFIELD, Bruce A

“…E7389, a macrocyclic ketone analog of the marine natural product halichondrin B, currently is undergoing clinical trials for cancer. This fully synthetic agent…”
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Neuropilin-1 drives tumor-specific uptake of chlorotoxin by McGonigle, Sharon, Majumder, Utpal, Kolber-Simonds, Donna, Wu, Jiayi, Hart, Andrew, Noland, Thomas, TenDyke, Karen, Custar, Daniel, Li, Danyang, Du, Hong, Postema, Maarten H D, Lai, W George, Twine, Natalie C, Woodall-Jappe, Mary, Nomoto, Kenichi

“…Chlorotoxin (Cltx) isolated from scorpion venom is an established tumor targeting and antiangiogenic peptide. Radiolabeled Cltx therapeutic ( I-TM601) yielded…”
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Potent in vitro and in vivo anticancer activities of des-methyl, des-amino pateamine A, a synthetic analogue of marine natural product pateamine A by Kuznetsov, Galina, Xu, Qunli, Rudolph-Owen, Lori, Tendyke, Karen, Liu, Junke, Towle, Murray, Zhao, Nanding, Marsh, Joanne, Agoulnik, Sergei, Twine, Natalie, Parent, Lana, Chen, Zhihong, Shie, Jue-Lon, Jiang, Yimin, Zhang, Huiming, Du, Hong, Boivin, Roch, Wang, Yuan, Romo, Daniel, Littlefield, Bruce A

“…We report here that des-methyl, des-amino pateamine A (DMDA-PatA), a structurally simplified analogue of the marine natural product pateamine A, has potent…”
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Structures and Cytotoxic Evaluation of New and Known Acyclic Ene-Ynes from an American Samoa Petrosia sp. Sponge by Mejia, Eric J, Magranet, Lindsay B, De Voogd, Nicole J, TenDyke, Karen, Qiu, Dayong, Shen, Young Yongchun, Zhou, Zhongrui, Crews, Phillip

“…Four new compounds, (−)-petrosynoic acids A–D (1–4), and five known congeners, pellynols A (5), C (6), D (7), F (8), and I (9), were isolated from a Petrosia…”
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Tubulin-based antimitotic mechanism of E7974, a novel analogue of the marine sponge natural product hemiasterlin by Kuznetsov, Galina, TenDyke, Karen, Towle, Murray J, Cheng, Hongsheng, Liu, Junke, Marsh, Joanne P, Schiller, Shawn E R, Spyvee, Mark R, Yang, Hu, Seletsky, Boris M, Shaffer, Christina J, Marceau, Veronique, Yao, Ye, Suh, Edward M, Campagna, Silvio, Fang, Francis G, Kowalczyk, James J, Littlefield, Bruce A

“…E7974 is a synthetic analogue of the marine sponge natural product hemiasterlin. Here, we show that E7974, such as parental hemiasterlin, acts via a…”
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Antiproliferative homoscalarane sesterterpenes from two Madagascan sponges by Harinantenaina, Liva, Brodie, Peggy J., Maharavo, Jean, Bakary, Gisele, TenDyke, Karen, Shen, Yongchun, Kingston, David G.I.

“…Dereplication of the antiproliferative ethyl acetate fraction of the Madagascan sponge Carteriospongia sp. led to the detection and isolation of the two known…”
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Nitrogen-Containing Dimeric nor-Multiflorane Triterpene from a Turraea sp by Rasamison, Vincent E, Rakotondraibe, L. Harinantenaina, Slebodnick, Carla, Brodie, Peggy J, Ratsimbason, Michel, TenDyke, Karen, Shen, Yongchun, Randrianjanaka, Lucien M, Kingston, David G. I

“…The new triterpene turranoic acid (1) and the new N-containing nor-triterpene turraenine (2), along with triptocallic acid B (3) and esculentoic acid (4) were…”
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Antiproliferative Compounds from Cleistanthus boivinianus from the Madagascar Dry Forest1 by Liu, Yixi, Young, Kelly, Rakotondraibe, L. Harinantenaina, Brodie, Peggy J., Wiley, Jessica D., Cassera, Maria B., Callmander, Martin W., Rakotondrajaona, R., Rakotobe, Etienne, Rasamison, Vincent E., TenDyke, Karen, Shen, Yongchun, Kingston, David G. I.

“…The two new lignans 3α- O -(β- d -glucopyranosyl)desoxypodophyllotoxin ( 1 ) and 4- O -(β- d -glucopyranosyl)dehydropodophyllotoxin ( 2 ) were isolated from…”
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Antiproliferative Acetogenins from a Uvaria sp. from the Madagascar Dry Forest by Dai, Yumin, Harinantenaina, Liva, Brodie, Peggy J, Callmander, Martin W, Randrianaivo, Richard, Rakotonandrasana, Stephan, Rakotobe, Etienne, Rasamison, Vincent E, Shen, Yongchun, TenDyke, Karen, Suh, Edward M, Kingston, David G. I

“…Investigation of the endemic Madagascan plant Uvaria sp. for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of two…”
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Isolation and Synthesis of Antiproliferative Eupolauridine Alkaloids of Ambavia gerrardii from the Madagascar Dry Forest by Pan, Ende, Cao, Shugeng, Brodie, Peggy J, Callmander, Martin W, Randrianaivo, Richard, Rakotonandrasana, Stephan, Rakotobe, Etienne, Rasamison, Vincent E, TenDyke, Karen, Shen, Yongchun, Suh, Edward M, Kingston, David G. I

“…Investigation of the Madagascan endemic plant Ambavia gerrardii for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation…”
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Antiproliferative Triterpenoid Saponins of Dodonaea viscosa from the Madagascar Dry Forest by Cao, Shugeng, Brodie, Peggy, Callmander, Martin, Randrianaivo, Richard, Razafitsalama, Jeremi, Rakotobe, Etienne, Rasamison, Vincent E, TenDyke, Karen, Shen, Yongchun, Suh, Edward M, Kingston, David G. I

“…Bioassay-guided fractionation of an EtOH extract obtained from the roots of the Madagascan plant Dodonaea viscosa led to the isolation of two new…”
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Antiproliferative Compounds from Pongamiopsis pervilleana from the Madagascar Dry Forest by Harinantenaina, Liva, Brodie, Peggy J, Slebodnick, Carla, Callmander, Martin W, Rakotobe, Etienne, Randrianasolo, Sennen, Randrianaivo, Richard, Rasamison, Vincent E, TenDyke, Karen, Shen, Yongchun, Suh, Edward M, Kingston, David G. I

“…Bioassay-guided fractionation of an ethanol extract of the roots of the endemic Malagasy plant Pongamiopsis pervilleana led to the isolation of the three new…”
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Structure elucidation of antiproliferative bisbenzylisoquinoline alkaloids from Anisocycla grandidieri from the Madagascar dry forest by Liu, Yixi, Harinantenaina, Liva, Brodie, Peggy J., Slebodnick, Carla, Callmander, Martin W., Rakotondrajaona, R., Rakotobe, Etienne, Rasamison, Vincent E., TenDyke, Karen, Shen, Yongchun, Kingston, David G. I.

“…Antiproliferative bioassay‐guided fractionation of the ethanol extract of the stems of Anisocycla grandidieri led to the isolation of the known alkaloids…”
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Novel second generation analogs of eribulin. Part III: Blood–brain barrier permeability and in vivo activity in a brain tumor model by Narayan, Sridhar, Carlson, Eric M., Cheng, Hongsheng, Condon, Krista, Du, Hong, Eckley, Sean, Hu, Yongbo, Jiang, Yimin, Kumar, Vipul, Lewis, Bryan M., Saxton, Philip, Schuck, Edgar, Seletsky, Boris M., Tendyke, Karen, Zhang, Huiming, Zheng, Wanjun, Littlefield, Bruce A., Towle, Murray J., Yu, Melvin J.

“…Novel second generation analogs of eribulin mesylate, a tubulin agent recently approved for the treatment of breast cancer, are reported. Our recent efforts…”
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Novel second generation analogs of eribulin. Part I: Compounds containing a lipophilic C32 side chain overcome P-glycoprotein susceptibility by Narayan, Sridhar, Carlson, Eric M., Cheng, Hongsheng, Du, Hong, Hu, Yongbo, Jiang, Yimin, Lewis, Bryan M., Seletsky, Boris M., Tendyke, Karen, Zhang, Huiming, Zheng, Wanjun, Littlefield, Bruce A., Towle, Murray J., Yu, Melvin J.

“…Eribulin mesylate (Halaven™), a totally synthetic analog of the marine polyether macrolide halichondrin B, has recently been approved in the United States as a…”
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Two Antiproliferative Triterpene Saponins from Nematostylis anthophylla from the Highlands of Central Madagascar by Dai, Yumin, Harinantenaina, Liva, Brodie, Peggy J., Birkinshaw, Chris, Randrianaivo, Richard, Applequist, Wendy, Ratsimbason, Michel, Rasamison, Vincent E., Shen, Yongchun, TenDyke, Karen, Kingston, David G. I.

“…Investigation of the endemic Madagascan plant Nematostylis anthophylla (Rubiaceae) for antiproliferative activity against the A2780 ovarian cancer cell line…”
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Cytotoxic Triterpenoid Saponins of Albizia gummifera from the Madagascar Rain Forest ∇ ,1 by Cao, Shugeng, Norris, Andrew, Miller, James S, Ratovoson, Fidy, Razafitsalama, Jeremi, Andriantsiferana, Rabodo, Rasamison, Vincent E, TenDyke, Karen, Suh, Ted, Kingston, David G. I

“…Bioassay-guided fractionation of an EtOH extract obtained from the roots of the Madagascan plant Albizia gummifera led to the isolation of three new cytotoxic…”
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E7766, a Macrocycle‐Bridged Stimulator of Interferon Genes (STING) Agonist with Potent Pan‐Genotypic Activity by Kim, Dae‐Shik, Endo, Atsushi, Fang, Francis G., Huang, Kuan‐Chun, Bao, Xingfeng, Choi, Hyeong‐wook, Majumder, Utpal, Shen, Young Y., Mathieu, Steven, Zhu, Xiaojie, Sanders, Kristen, Noland, Thomas, Hao, Ming‐Hong, Chen, Yu, Wang, John Y., Yasui, So, TenDyke, Karen, Wu, Jiayi, Ingersoll, Christy, Loiacono, Kara A., Hutz, Janna E., Sarwar, Nadeem

“…A strategy for creating potent and pan‐genotypic stimulator of interferon genes (STING) agonists is described. Locking a bioactive U‐shaped conformation of…”
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