Search Results - "Tena, Manuel"

Sex Differences in the Gut Microbiota as Potential Determinants of Gender Predisposition to Disease by Santos‐Marcos, Jose A., Haro, Carmen, Vega‐Rojas, Ana, Alcala‐Diaz, Juan F., Molina‐Abril, Helena, Leon‐Acuña, Ana, Lopez‐Moreno, Javier, Landa, Blanca B., Tena‐Sempere, Manuel, Perez‐Martinez, Pablo, Lopez‐Miranda, Jose, Perez‐Jimenez, Francisco, Camargo, Antonio

“…Scope Dysbiosis of gut microbiota is involved in metabolic syndrome (MetS) development, which has a different incidence between men (M) and women (W). The…”
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Metabolic dysfunction in polycystic ovary syndrome: Pathogenic role of androgen excess and potential therapeutic strategies by Sanchez-Garrido, Miguel A., Tena-Sempere, Manuel

“…Polycystic ovary syndrome (PCOS) is the most common endocrinopathy among reproductive age women. Although its cardinal manifestations include hyperandrogenism,…”
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Precocious sexual maturation: Unravelling the mechanisms of pubertal onset through clinical observations by Soriano‐Guillén, Leandro, Tena‐Sempere, Manuel, Seraphim, Carlos E., Latronico, Ana C., Argente, Jesús

“…Puberty is a crucial biological process normally occurring at a specific time during the lifespan, during which sexual and somatic maturation are completed,…”
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Kisspeptins centrally modulate food intake and locomotor activity in mice independently of gonadal steroids in a sexually dimorphic manner by Velasco, Inmaculada, Daza‐Dueñas, Silvia, Torres, Encarnación, Ruiz‐Pino, Francisco, Vázquez, María J., Tena‐Sempere, Manuel

“…Kisspeptins are essential regulators of the reproductive axis, with capacity to potently activate gonadotropin‐releasing hormone neurons, acting also as…”
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Kisspeptins and reproduction: physiological roles and regulatory mechanisms by Pinilla, Leonor, Aguilar, Enrique, Dieguez, Carlos, Millar, Robert P, Tena-Sempere, Manuel

“…Procreation is essential for survival of species. Not surprisingly, complex neuronal networks have evolved to mediate the diverse internal and external…”
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The kisspeptin receptor: A key G-protein-coupled receptor in the control of the reproductive axis by Franssen, Delphine, Tena-Sempere, Manuel

“…The kisspeptin receptor, Kiss1R, also known as Gpr54, is a G protein-coupled receptor (GPCR), deorphanized in 2001, when it was recognized as canonical…”
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Estrogens and the control of energy homeostasis: a brain perspective by López, Miguel, Tena-Sempere, Manuel

“…Highlights • Estrogens are pleiotropic regulators affecting not only reproduction but also metabolism. • Estrogen deprivation induces hyperphagia, low…”
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KLB, encoding β‐Klotho, is mutated in patients with congenital hypogonadotropic hypogonadism by Xu, Cheng, Messina, Andrea, Somm, Emmanuel, Miraoui, Hichem, Kinnunen, Tarja, Acierno, James, Niederländer, Nicolas J, Bouilly, Justine, Dwyer, Andrew A, Sidis, Yisrael, Cassatella, Daniele, Sykiotis, Gerasimos P, Quinton, Richard, De Geyter, Christian, Dirlewanger, Mirjam, Schwitzgebel, Valérie, Cole, Trevor R, Toogood, Andrew A, Kirk, Jeremy MW, Plummer, Lacey, Albrecht, Urs, Crowley, William F, Mohammadi, Moosa, Tena‐Sempere, Manuel, Prevot, Vincent, Pitteloud, Nelly

“…Congenital hypogonadotropic hypogonadism (CHH) is a rare genetic form of isolated gonadotropin‐releasing hormone (GnRH) deficiency caused by mutations in > 30…”
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The Kiss1 system and polycystic ovary syndrome: lessons from physiology and putative pathophysiologic implications by Witchel, Selma F., M.D, Tena-Sempere, Manuel, M.D

“…Polycystic ovary syndrome (PCOS) is a highly prevalent heterogeneous disease characterized by ovulatory dysfunction, hyperandrogenism, and metabolic…”
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Extrahypothalamic Control of Energy Balance and Its Connection with Reproduction: Roles of the Amygdala by Pineda, Rafael, Torres, Encarnacion, Tena-Sempere, Manuel

“…Body energy and metabolic homeostasis are exquisitely controlled by multiple, often overlapping regulatory mechanisms, which permit the tight adjustment…”
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Metabolic control of puberty: Roles of leptin and kisspeptins by Sanchez-Garrido, Miguel A., Tena-Sempere, Manuel

“…This article is part of a Special Issue “Puberty and Adolescence”. Reproduction is an energy-demanding function. Accordingly, puberty is metabolically gated,…”
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Intestinal Microbiota Is Influenced by Gender and Body Mass Index by Haro, Carmen, Rangel-Zúñiga, Oriol A, Alcalá-Díaz, Juan F, Gómez-Delgado, Francisco, Pérez-Martínez, Pablo, Delgado-Lista, Javier, Quintana-Navarro, Gracia M, Landa, Blanca B, Navas-Cortés, Juan A, Tena-Sempere, Manuel, Clemente, José C, López-Miranda, José, Pérez-Jiménez, Francisco, Camargo, Antonio

“…Intestinal microbiota changes are associated with the development of obesity. However, studies in humans have generated conflicting results due to high…”
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Kisspeptins and the neuroendocrine control of reproduction: Recent progress and new frontiers in kisspeptin research by Sobrino, Veronica, Avendaño, Maria Soledad, Perdices-López, Cecilia, Jimenez-Puyer, Manuel, Tena-Sempere, Manuel

“…•Kisspeptins interplay with tachykinins, α-MSH and Mkrn3 for the central control of puberty.•KNDy neurons are key components of the GnRH pulse generator.•KNDy…”
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Metabolic control of female puberty: potential therapeutic targets by Castellano, Juan M, Tena-Sempere, Manuel

“…The onset of puberty in females is highly sensitive to the nutritional status and the amount of energy reserves of the organism. This metabolic information is…”
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An International Consortium Update: Pathophysiology, Diagnosis, and Treatment of Polycystic Ovarian Syndrome in Adolescence by Ibáñez, Lourdes, Oberfield, Sharon E, Witchel, Selma, Auchus, Richard J, Chang, R Jeffrey, Codner, Ethel, Dabadghao, Preeti, Darendeliler, Feyza, Elbarbary, Nancy Samir, Gambineri, Alessandra, Garcia Rudaz, Cecilia, Hoeger, Kathleen M, López-Bermejo, Abel, Ong, Ken, Peña, Alexia S, Reinehr, Thomas, Santoro, Nicola, Tena-Sempere, Manuel, Tao, Rachel, Yildiz, Bulent O, Alkhayyat, Haya, Deeb, Asma, Joel, Dipesalema, Horikawa, Reiko, de Zegher, Francis, Lee, Peter A

“…This paper represents an international collaboration of paediatric endocrine and other societies (listed in the Appendix) under the International Consortium of…”
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HYPOTHALAMIC EXPRESSION OF THE PRADER-WILLI SYNDROME-RELATED GENES MAGEL2 AND NDN AND THEIR POTENTIAL REGULATORY MICRORNAS THROUGHOUT PUBERTAL DEVELOPMENT AND UNDER CONDITIONS OF METABOLIC STRESS by Torrecillas, Álvaro Aranda, Vázquez, Elvira Rodríguez, Sánchez, Ana Rodríguez, Galiano, David García, Sempere, Manuel Tena, Rodríguez, Juan Castellano

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Comparative insights of the kisspeptin/kisspeptin receptor system: Lessons from non-mammalian vertebrates by Tena-Sempere, Manuel, Felip, Alicia, Gómez, Ana, Zanuy, Silvia, Carrillo, Manuel

“…Highlights ► Kisspeptins, products of Kiss1 , are important regulators of reproduction in mammals. ► Kiss and gpr54 have been recently studied in non-mammals…”
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Generation of multi-oocyte follicles in the peripubertal rat ovary: link to the invasive capacity of granulosa cells? by Gaytán, Francisco, M.D., Ph.D, Morales, Concepción, M.D., Ph.D, Manfredi-Lozano, María, B.Sc, Tena-Sempere, Manuel, M.D., Ph.D

“…Objective To assess the presence and numbers of multi-oocyte follicles (MOFs) in the rat ovary at different stages of postnatal maturation. Design Animal (rat)…”
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GnRH replacement rescues cognition in Down syndrome by Manfredi-Lozano, Maria, Leysen, Valerie, Adamo, Michela, Paiva, Isabel, Rovera, Renaud, Pignat, Jean-Michel, Timzoura, Fatima Ezzahra, Candlish, Michael, Eddarkaoui, Sabiha, Malone, Samuel A, Silva, Mauro S B, Trova, Sara, Imbernon, Monica, Decoster, Laurine, Cotellessa, Ludovica, Tena-Sempere, Manuel, Claret, Marc, Paoloni-Giacobino, Ariane, Plassard, Damien, Paccou, Emmanuelle, Vionnet, Nathalie, Acierno, James, Maceski, Aleksandra Maleska, Lutti, Antoine, Pfrieger, Frank, Rasika, S, Santoni, Federico, Boehm, Ulrich, Ciofi, Philippe, Buée, Luc, Haddjeri, Nasser, Boutillier, Anne-Laurence, Kuhle, Jens, Messina, Andrea, Draganski, Bogdan, Giacobini, Paolo, Pitteloud, Nelly, Prevot, Vincent

“…At the present time, no viable treatment exists for cognitive and olfactory deficits in Down syndrome (DS). We show in a DS model (Ts65Dn mice) that these…”
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Author Correction: A novel RGB-trichrome staining method for routine histological analysis of musculoskeletal tissues by Gaytan, Francisco, Morales, Concepción, Reymundo, Carlos, Tena-Sempere, Manuel

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