Search Results - "TenBrink, R"

267 HEALTHY MINDS, HEALTHY JOINTS: DEFINING A NOVEL ROLE FOR BACE1 IN CARTILAGE EROSION by Tortorella, M, Tomasselli, A, Song, L, TenBrink, R, Anglin, C, Malfait, A.-M

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Preclinical studies characterizing the anti-migraine and cardiovascular effects of the selective 5-HT1D receptor agonist PNU-142633 by McCall, R B, Huff, R, Chio, C L, TenBrink, R, Bergh, C L, Ennis, M D, Ghazal, N B, Hoffman, R L, Meisheri, K, Higdon, N R, Hall, E

“…The present study describes the preclinical pharmacology of a highly selective 5-HT1D receptor agonist PNU-142633. PNU-142633 binds with a Ki of 6 nm at the…”
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PNU-96415E, a potential antipsychotic agent with clozapine-like pharmacological properties by Tang, A H, Franklin, S R, Himes, C S, Smith, M W, Tenbrink, R E

“…The atypical antipsychotic drug clozapine interacts with multiple transmitter systems, among them the D4 subtype of dopamine receptors. PNU-96415E is…”
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Pharmacological characterization of U-101387, a dopamine D4 receptor selective antagonist by Merchant, K M, Gill, G S, Harris, D W, Huff, R M, Eaton, M J, Lookingland, K, Lutzke, B S, Mccall, R B, Piercey, M F, Schreur, P J, Sethy, V H, Smith, M W, Svensson, K A, Tang, A H, Vonvoigtlander, P F, Tenbrink, R E

“…Dopamine D2-like receptors play an important role in the pharmacotherapy of psychotic disorders. Molecular and cellular techniques have identified distinct…”
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(S)-(−)-4-[4-[2-(Isochroman-1-yl)ethyl]piperazin-1-yl]benzenesulfonamide, a Selective Dopamine D4 Antagonist by TenBrink, Ruth E, Bergh, Carol L, Duncan, J. Neil, Harris, Douglas W, Huff, R. M, Lahti, Robert A, Lawson, Charles F, Lutzke, Barry S, Martin, Iain J, Rees, Susan A, Schlachter, Siusaidh K, Sih, John C, Smith, Martin W

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Differential pharmacology between the guinea‐pig and the gorilla 5‐HT1D receptor as probed with isochromans (5‐HT1D‐selective ligands) by Pregenzer, Jeffrey F, Alberts, Glen L, Im, Wha Bin, Slightom, Jerry L, Ennis, Michael D, Hoffman, Robert L, Ghazal, Nabil B, TenBrink, Ruth E

“…Both the 5‐HT1D and 5‐HT1B receptors are implicated in migraine pathophysiology. Recently isochromans have been discovered to bind primate 5‐HT1D receptors…”
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High-Affinity Partial Agonist Imidazo[1,5-a]quinoxaline Amides, Carbamates, and Ureas at the γ-Aminobutyric Acid A/Benzodiazepine Receptor Complex by Jacobsen, E. Jon, TenBrink, Ruth E, Stelzer, Lindsay S, Belonga, Kenneth L, Carter, Donald B, Im, Haesook K, Im, Wha Bin, Sethy, Vimala H, Tang, Andy H, VonVoigtlander, Philip F, Petke, James D

“…A series of imidazo[1,5-a]quinoxaline amides, carbamates, and ureas which have high affinity for the γ-aminobutyric acid A/benzodiazepine receptor complex was…”
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Piperazine Imidazo[1,5-a]quinoxaline Ureas as High-Affinity GABAA Ligands of Dual Functionality by Jacobsen, E. Jon, Stelzer, Lindsay S, TenBrink, Ruth E, Belonga, Kenneth L, Carter, Donald B, Im, Haesook K, Im, Wha Bin, Sethy, Vimala H, Tang, Andy H, VonVoigtlander, Philip F, Petke, James D, Zhong, Wei-Zhu, Mickelson, John W

“…A series of imidazo[1,5-a]quinoxaline piperazine ureas appended with a tert-butyl ester side chain at the 3-position was developed. Analogues within this…”
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Inhibitors of the protease from human immunodeficiency virus: synthesis, enzyme inhibition, and antiviral activity of a series of compounds containing the dihydroxyethylene transition-state isostere by Thaisrivongs, Suvit, Turner, Steve R, Strohbach, Joseph W, TenBrink, Ruth E, Tarpley, W. Gary, McQuade, Thomas J, Heinrikson, Robert L, Tomasselli, Alfredo G, Hui, John O, Howe, W. Jeffrey

“…A number of potential HIV protease inhibitory peptides that contain the dihydroxyethylene isostere were prepared and evaluated for their enzyme binding…”
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Arylformamidines with antinociceptive properties by Gall, M, McCall, J. M, TenBrink, R. E, VonVoigtlander, P. F, Mohrland, J. S

“…A series of formamidines structurally related to clonidine were synthesized and investigated as potential nonopiate analgesics. Several of these compounds…”
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7-(Trifluoromethyl)-4-aminoquinoline hypotensives: novel peripheral sympatholytics by McCall, John M, TenBrink, R. E, Kamdar, Bharat V, Skaletzky, Louis L, Perricone, Salvatore C, Piper, Richard C, Delehanty, Patrick J

“…A family of 7-(trifluoromethyl)-4-aminoquinolines that are hypotensive agents and that act by a novel sympatholytic mechanism is described. Structure-activity…”
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Differential affinity of dihydroimidazoquinoxalines and diimidazoquinazolines to the alpha 1 beta 2 gamma 2 and alpha 6 beta 2 gamma 2 subtypes of cloned GABAA receptors by Im, W B, Im, H K, Pregenzer, J F, Hamilton, B J, Carter, D B, Jacobsen, E J, TenBrink, R E, VonVoigtlander, P F

“…1. In this study, we compared two series of newly discovered ligands for their selectivity to benzodiazepine sites in the alpha 1 beta 2 gamma 2 and the alpha…”
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A method for the preparation of stereochemically defined .psi.[CH2O] pseudodipeptides by TenBrink, Ruth E

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Renin inhibitors containing .psi.[CH2O] pseudopeptide inserts by Ten Brink, Ruth E, Pals, Donald T, Harris, Douglas W, Johnson, Garland A

“…Renin inhibitors 2-4 with the D-Lys renin inhibitory peptide (RIP) sequence, but containing Leu psi[CH2O]Ala (2), Leu psi[CH2O]Val (3), and Leu psi[CH2O]Leu…”
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New approach to triaminopyrimidine N-oxides by McCall, J. M, TenBrink, R. E, Ursprung, J. J

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1-(Alkylamino)isochromans: hypotensives with peripheral and central activities by McCall, J. M, McCall, R. B, TenBrink, R. E, Kamdar, B. V, Humphrey, S. J, Sethy, V. H, Harris, D. W, Daenzer, C

“…A series of 1-[1-(3,4-dimethoxy-1H-2-benzopyran-1-yl)alkyl]-4-arylpiperazines that shows hypotensive activity in the conscious rat has been investigated…”
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Formation and reactions of 1-phenyl-2-propanone dianion and related systems with electrophilic reagents by Trimitsis, G. B, Hinkley, J. M, TenBrink, R, Faburada, A. L, Anderson, R, Poli, M, Christian, B, Gustafson, G, Erdman, J, Rop, D

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Unusual mode of alkylation of certain ketone dianions by Trimitsis, G. B, Hinkley, J. M, TenBrink, R, Poli, M, Gustafson, G, Erdman, J, Rop, D

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Antagonist, Partial Agonist, and Full Agonist Imidazo[1,5-a]quinoxaline Amides and Carbamates Acting through the GABAA/Benzodiazepine Receptor by TenBrink, Ruth E, Im, Wha B, Sethy, Vimala H, Tang, Andrew H, Carter, Don B

“…(4RS)-1-(5-Cyclopropyl-1,2,4-oxadiazol-3-yl)-12,12a-dihyd roimidazo[1,5- a]pyrrolo[2,1-c]quinoxalin-10(11H)-one (1a),…”
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1-[(Ethoxyamino)methyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzoxepins: a new class of antianaphylactic agents by TenBrink, Ruth E, McCall, John M, Johnson, Herbert G

“…The synthesis and biological activity in the rat passive cutaneous anaphylaxis (PCA) test of a new class of compounds,…”
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