Search Results - "Ten Brinke, Anneke"
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Alpine altitude climate treatment for severe and uncontrolled asthma: An EAACI position paper
Published in Allergy (Copenhagen) (01-07-2022)“…Currently available European Alpine Altitude Climate Treatment (AACT) programs combine the physical characteristics of altitude with the avoidance of…”
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Systematic Assessment of Difficult-to-Treat Asthma: Principles and Perspectives
Published in The journal of allergy and clinical immunology in practice (Cambridge, MA) (01-07-2020)“…Difficult-to-treat asthma affects a minority of adults and children with asthma but represents a challenging mix of misdiagnosis, multimorbidity, inadequate…”
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Management of the patient with eosinophilic asthma: a new era begins
Published in ERJ open research (01-05-2015)“…Now that it is generally accepted that asthma is a heterogeneous condition, phenotyping of asthma patients has become a mandatory part of the diagnostic workup…”
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Clinical profile of patients with adult-onset eosinophilic asthma
Published in ERJ open research (01-04-2016)“…Adult-onset eosinophilic asthma is increasingly recognised as a severe and difficult-to-treat subtype of asthma. In clinical practice, early recognition of…”
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"Refractory" Eosinophilic Airway Inflammation in Severe Asthma: Effect of Parenteral Corticosteroids
Published in American journal of respiratory and critical care medicine (15-09-2004)“…It has been suggested that patients with refractory eosinophilic airway inflammation represent a separate "eosinophilic" asthma phenotype associated with…”
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Consistency of sputum eosinophilia in difficult-to-treat asthma: A 5-year follow-up study
Published in Journal of allergy and clinical immunology (01-09-2009)“…Characteristics of patients and methods are described elsewhere in detail.3,6,7 In 1998 and 1999 (visit 1), patient characteristics (sex, age, atopic status,…”
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Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsìveness, and the late asthmatic response
Published in The Lancet (British edition) (23-12-2000)“…Interleukin-5 (IL-5) is essential for the formation of eosinophils, which are thought to have a major role in the pathogenesis of asthma and other allergic…”
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Clinical response to benralizumab can be predicted by combining clinical outcomes at 3 months with baseline characteristics
Published in ERJ open research (01-03-2023)“…Benralizumab is highly effective in many, but not all, patients with severe asthma. Baseline characteristics alone are insufficient to predict an individual's…”
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Treatment Eligibility of Real-Life Mepolizumab-Treated Severe Asthma Patients
Published in The journal of allergy and clinical immunology in practice (Cambridge, MA) (01-10-2020)“…Patients with severe asthma not meeting the strict trial eligibility criteria for mepolizumab are now routinely treated with this biological in clinical…”
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What bothers severe asthma patients most? A paired patient-clinician study across seven European countries
Published in ERJ open research (01-05-2023)“…Severe asthma is a complex, multidimensional disease. Optimal treatment, adherence and outcomes require shared decision-making, rooted in mutual understanding…”
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Severe adult-onset asthma: A distinct phenotype
Published in Journal of allergy and clinical immunology (01-08-2013)“…Background Some patients with adult-onset asthma have severe disease, whereas others have mild transient disease. It is currently unknown whether patients with…”
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Blueprint for harmonising unstandardised disease registries to allow federated data analysis: prepare for the future
Published in ERJ open research (01-10-2022)“…Real-world evidence from multinational disease registries is becoming increasingly important not only for confirming the results of randomised controlled…”
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SHARP: enabling generation of real-world evidence on a pan-European scale to improve the lives of individuals with severe asthma
Published in ERJ open research (01-04-2021)“…Real-world evidence is important to help unravel unanswered problems in severe asthma and is valuable to better understand the patient experience and common…”
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Characteristics of severe asthma patients on biologics: a real-life European registry study
Published in ERJ open research (01-05-2023)“…The use of anti-interleukin-5 (IL5) for severe asthma is based on criteria from randomised controlled trials (RCTs), but in real-life patients might not fulfil…”
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Long-Term Therapy Response to Anti–IL-5 Biologics in Severe Asthma—A Real-Life Evaluation
Published in The journal of allergy and clinical immunology in practice (Cambridge, MA) (01-03-2021)“…Patients with severe eosinophilic asthma show different responses to various anti–IL-5 biologics, ranging from super response to nonresponse. Residual disease…”
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Efficacy of mepolizumab add-on therapy on health-related quality of life and markers of asthma control in severe eosinophilic asthma (MUSCA): a randomised, double-blind, placebo-controlled, parallel-group, multicentre, phase 3b trial
Published in The lancet respiratory medicine (01-05-2017)“…Summary Background Mepolizumab, an anti-interleukin-5 monoclonal antibody approved as add-on therapy to standard of care for patients with severe eosinophilic…”
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Poor outcome of SARS-CoV-2 infection in patients with severe asthma on biologic therapy
Published in Respiratory medicine (01-02-2021)“…It is unclear whether asthma and asthma medications increase or decrease the risk of severe COVID-19, and this is particularly true for patients with severe…”
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Biomarkers to identify sputum eosinophilia in different adult asthma phenotypes
Published in The European respiratory journal (01-09-2015)“…Several biomarkers have been used to assess sputum eosinophilia in asthma. It has been suggested that the diagnostic accuracy of these biomarkers might differ…”
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Targeting dynamic hyperinflation in moderate-to-severe asthma: a randomised controlled trial
Published in ERJ open research (01-07-2021)“…Background Dynamic hyperinflation is highly prevalent in moderate-to-severe asthma, which may significantly impede activities of daily life. We hypothesised…”
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