Search Results - "Tempra, Carmelo"

Lipid-Chaperone Hypothesis: A Common Molecular Mechanism of Membrane Disruption by Intrinsically Disordered Proteins by Sciacca, Michele F, Lolicato, Fabio, Tempra, Carmelo, Scollo, Federica, Sahoo, Bikash R, Watson, Matthew D, García-Viñuales, Sara, Milardi, Danilo, Raudino, Antonio, Lee, Jennifer C, Ramamoorthy, Ayyalusamy, La Rosa, Carmelo

“…An increasing number of human diseases has been shown to be linked to aggregation and amyloid formation by intrinsically disordered proteins (IDPs). Amylin,…”
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Can calmodulin bind to lipids of the cytosolic leaflet of plasma membranes? by Scollo, Federica, Tempra, Carmelo, Evci, Hüseyin, Riopedre-Fernandez, Miguel, Olżyńska, Agnieszka, Javanainen, Matti, Uday, Arunima, Cebecauer, Marek, Cwiklik, Lukasz, Martinez-Seara, Hector, Jungwirth, Pavel, Jurkiewicz, Piotr, Hof, Martin

“…Calmodulin (CaM) is a ubiquitous calcium-sensitive messenger in eukaryotic cells. It was previously shown that CaM possesses an affinity for diverse lipid…”
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Sweet taste of heavy water by Ben Abu, Natalie, Mason, Philip E., Klein, Hadar, Dubovski, Nitzan, Ben Shoshan-Galeczki, Yaron, Malach, Einav, Pražienková, Veronika, Maletínská, Lenka, Tempra, Carmelo, Chamorro, Victor Cruces, Cvačka, Josef, Behrens, Maik, Niv, Masha Y., Jungwirth, Pavel

“…Hydrogen to deuterium isotopic substitution has only a minor effect on physical and chemical properties of water and, as such, is not supposed to influence its…”
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Effects of Water Deuteration on Thermodynamic and Structural Properties of Proteins and Biomembranes by Tempra, Carmelo, Chamorro, Victor Cruces, Jungwirth, Pavel

“…Light and heavy water are often used interchangeably in spectroscopic experiments with the tacit assumption that the structure of the investigated biomolecule…”
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Heavy Water Models for Classical Molecular Dynamics: Effective Inclusion of Nuclear Quantum Effects by Chamorro, Victor Cruces, Tempra, Carmelo, Jungwirth, Pavel

“…Small differences in physical and chemical properties of H2O and D2O, such as melting and boiling points or pK a, can be traced back to a slightly stronger…”
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The role of alpha-helix on the structure-targeting drug design of amyloidogenic proteins by Tempra, Carmelo, La Rosa, Carmelo, Lolicato, Fabio

“…The most accredited hypothesis links the toxicity of amyloid proteins to their harmful effects on membrane integrity through the formation of…”
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Amyloid growth and membrane damage: Current themes and emerging perspectives from theory and experiments on Aβ and hIAPP by Sciacca, Michele F.M., Tempra, Carmelo, Scollo, Federica, Milardi, Danilo, La Rosa, Carmelo

“…Alzheimer's Disease (AD) and Type 2 diabetes mellitus (T2DM) are two incurable diseases both hallmarked by an abnormal deposition of the amyloidogenic peptides…”
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Accurate Simulations of Lipid Monolayers Require a Water Model with Correct Surface Tension by Tempra, Carmelo, Ollila, O. H. Samuli, Javanainen, Matti

“…Lipid monolayers provide our lungs and eyes their functionality and serve as proxy systems in biomembrane research. Therefore, lipid monolayers have been…”
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A unifying framework for amyloid-mediated membrane damage: The lipid-chaperone hypothesis by Tempra, Carmelo, Scollo, Federica, Pannuzzo, Martina, Lolicato, Fabio, La Rosa, Carmelo

“…Over the past thirty years, researchers have highlighted the role played by a class of proteins or polypeptides that forms pathogenic amyloid aggregates in…”
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A comparison of lipid diffusive dynamics in monolayers and bilayers in the context of interleaflet coupling by Mandal, Titas, Brandt, Nadine, Tempra, Carmelo, Javanainen, Matti, Fábián, Balázs, Chiantia, Salvatore

“…Cellular membranes are composed of lipids typically organized in a double-leaflet structure. Interactions between these two leaflets – often referred to as…”
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Stealthy Player in Lipid Experiments? EDTA Binding to Phosphatidylcholine Membranes Probed by Simulations and Monolayer Experiments by Vazdar, Katarina, Tempra, Carmelo, Olżyńska, Agnieszka, Biriukov, Denys, Cwiklik, Lukasz, Vazdar, Mario

“…Ethylenediaminetetraacetic acid (EDTA) is frequently used in lipid experiments to remove redundant ions, such as Ca2+, from the sample solution. In this work,…”
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Calmodulin interactions with model lipid membranes: the interplay of Ca2+and lipid composition by Scollo, Federica, Tempra, Carmelo, Evci, Hüseyin, Jungwirth, Pavel, Hof, Martin, Martinez-Seara, Hector, Jurkiewicz, Piotr

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Phospholipids Critical Micellar Concentrations Trigger Different Mechanisms of Intrinsically Disordered Proteins Interaction with Model Membranes by Scollo, Federica, Tempra, Carmelo, Lolicato, Fabio, Sciacca, Michele F. M, Raudino, Antonio, Milardi, Danilo, La Rosa, Carmelo

“…Amyloidogenic proteins are involved in many diseases, including Alzheimer’s, Parkinson’s, and type II diabetes. These proteins are thought to be toxic for…”
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Prosecco: polarization reintroduced by optimal scaling of electronic continuum correction origin in MD simulations by Nencini, Ricky, Tempra, Carmelo, Biriukov, Denys, Polák, Jakub, Ondo, Daniel, Heyda, Jan, Ollila, Samuli O., Javanainen, Matti, Martinez-Seara, Hector

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Ionic Strength and Solution Composition Dictate the Adsorption of Cell-Penetrating Peptides onto Phosphatidylcholine Membranes by Nguyen, Man Thi Hong, Biriukov, Denys, Tempra, Carmelo, Baxova, Katarina, Martinez-Seara, Hector, Evci, Hüseyin, Singh, Vandana, Šachl, Radek, Hof, Martin, Jungwirth, Pavel, Javanainen, Matti, Vazdar, Mario

“…Adsorption of arginine-rich positively charged peptides onto neutral zwitterionic phosphocholine (PC) bilayers is a key step in the translocation of those…”
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Modulating Aβ aggregation by tyrosol-based ligands: The crucial role of the catechol moiety by Romanucci, Valeria, García-Viñuales, Sara, Tempra, Carmelo, Bernini, Roberta, Zarrelli, Armando, Lolicato, Fabio, Milardi, Danilo, Di Fabio, Giovanni

“…The abnormal deposition of Aβ amyloid deposits in the brain is a hallmark of Alzheimer's disease (AD). Based on this evidence, many current therapeutic…”
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Benefits of the Electronic Continuum Correction in Bio-Force Fields by Nencini, Ricky, Palivec, Vladimir, Tempra, Carmelo, Delcroix, Pauline, Ollila, Samuli O., Javanainen, Matti, Jungwirth, Pavel, Martinez-Seara, Hector

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Exposure to Aldehyde Cherry e‑Liquid Flavoring and Its Vaping Byproduct Disrupt Pulmonary Surfactant Biophysical Function by Martin, Alexia, Tempra, Carmelo, Yu, Yuefan, Liekkinen, Juho, Thakker, Roma, Lee, Hayoung, de Santos Moreno, Berta, Vattulainen, Ilpo, Rossios, Christos, Javanainen, Matti, Bernardino de la Serna, Jorge

“…Over the past decade, there has been a significant rise in the use of vaping devices, particularly among adolescents, raising concerns for effects on…”
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Effective Inclusion of Electronic Polarization Improves the Description of Electrostatic Interactions: The prosECCo75 Biomolecular Force Field by Nencini, Ricky, Tempra, Carmelo, Biriukov, Denys, Riopedre-Fernandez, Miguel, Cruces Chamorro, Victor, Polák, Jakub, Mason, Philip E., Ondo, Daniel, Heyda, Jan, Ollila, O. H. Samuli, Jungwirth, Pavel, Javanainen, Matti, Martinez-Seara, Hector

“…prosECCo75 is an optimized force field effectively incorporating electronic polarization via charge scaling. It aims to enhance the accuracy of nominally…”
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Can calmodulin bind to lipids of the cytosolic leaflet of plasma membranes? by Scollo, Federica, Tempra, Carmelo, Evci, Hüseyin, Riopedre-Fernandez, Miguel, Olżyńska, Agnieszka, Javanainen, Matti, Uday, Arunima, Cebecauer, Marek, Cwiklik, Lukasz, Martinez-Seara, Hector, Jungwirth, Pavel, Jurkiewicz, Piotr, Hof, Martin

“…Calmodulin (CaM) is a ubiquitous calcium-sensitive messenger in eukaryotic cells. It was previously shown that CaM possesses an affinity for diverse lipid…”
Get full text