Search Results - "Templeton, Douglas M."

Interplay of calcium and cadmium in mediating cadmium toxicity by Choong, Grace, Liu, Ying, Templeton, Douglas M.

“…•Cd has multiple effects on cell signaling, cytoskeletal remodeling, and cell death.•One integrative mechanism is the interaction of Cd2+ and Ca2+.•A major…”
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Protective effect of cadmium-induced autophagy in rat renal mesangial cells by Fujishiro, Hitomi, Liu, Ying, Ahmadi, Bilal, Templeton, Douglas M.

“…Cadmium damages renal cells, and in particular may cause mesangial cell death by necrosis or apoptosis, depending on exposure conditions in cultured cells…”
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Initiation of caspase-independent death in mouse mesangial cells by Cd2+: Involvement of p38 kinase and CaMK-II by Liu, Ying, Templeton, Douglas M.

“…Cadmium (Cd) is a toxic metal with multiple effects on cell signaling and cell death. We studied the effects of Cd2+ on quiescent mouse mesangial cells in…”
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Speciation in Metal Toxicity and Metal-Based Therapeutics by Templeton, Douglas M

“…Metallic elements, ions and compounds produce varying degrees of toxicity in organisms with which they come into contact. Metal speciation is critical to…”
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Pleiotropic effects of cadmium in mesangial cells by Xiao, Weiqun, Liu, Ying, Templeton, Douglas M.

“…The mesangial cell of the renal glomerulus is exposed to circulating toxic substances and is a target involved in the glomerular component of chronic…”
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Multiple roles of cadmium in cell death and survival by Templeton, Douglas M., Liu, Ying

“…Cadmium is a toxic metal with no known biological function. It is increasingly important as an environmental hazard to both humans and wildlife, and it…”
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Guidelines for terms related to chemical speciation and fractionation of elements. Definitions, structural aspects, and methodological approaches (IUPAC Recommendations 2000) by Templeton, Douglas M., Ariese, Freek, Cornelis, Rita, Danielsson, Lars-Göran, Muntau, Herbert, van Leeuwen, Herman P., Lobinski, Ryszard

“…This paper presents definitions of concepts related to speciation of elements, more particularly speciation analysis and chemical species. Fractionation is…”
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Terminology of elemental speciation – An IUPAC perspective by Templeton, Douglas M., Fujishiro, Hitomi

“…•IUPAC has recommended definitions of chemical species, speciation, and fractionation.•A structural definition of species ranges from isotopic composition to…”
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Interaction of iron regulatory protein-1 (IRP-1) with ATP/ADP maintains a non-IRE-binding state by Popovic, Zvezdana, Templeton, Douglas M

“…In its aconitase-inactive form, IRP-1 (iron regulatory protein-1)/cytosolic aconitase binds to the IRE (iron-responsive element) of several mRNAs to effect…”
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Effect of hypoxia on the binding and subcellular distribution of iron regulatory proteins by Christova, Tania, Templeton, Douglas M

“…Iron regulatory proteins 1 and 2 (IRP1, IRP2) are key determinants of uptake and storage of iron by the liver, and are responsive to oxidative stress and…”
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Undergraduate Specialist Program in Pathobiology at the University of Toronto by Templeton, Douglas M., Gotlieb, Avrum I.

“…Following a merger of the Departments of Pathology, Clinical Biochemistry, and part of Medical Microbiology, our faculty agreed to deliver a new, unique…”
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Cadmium favors F-actin depolymerization in rat renal mesangial cells by site-specific, disulfide-based dimerization of the CAP1 protein by Liu, Ying, Xiao, Weiqun, Shinde, Manasi, Field, Jeffrey, Templeton, Douglas M.

“…Cadmium is a toxic metal that produces oxidative stress and has been shown to disrupt the actin cytoskeleton in rat renal mesangial cells (RMC). In a survey of…”
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Cytokine profiles in human exposure to metals (IUPAC Technical Report) by Klein, Reinhild, Schwenk, Michael, Templeton, Douglas M.

“…Immunosensitization to metal ions through occupational and environmental exposure has been described in earlier papers from this project. Here we discuss the…”
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Cadmium affects focal adhesion kinase (FAK) in mesangial cells: Involvement of CaMK-II and the actin cytoskeleton by Choong, Grace, Liu, Ying, Templeton, Douglas M.

“…The toxic metal ion cadmium (Cd2+) induces pleiotropic effects on cell death and survival, in part through effects on cell signaling mechanisms and…”
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Iron accumulation and iron-regulatory protein activity in human hepatoma (HepG2) cells by Popovic, Zvezdana, Templeton, Douglas M

“…Iron may populate distinct hepatocellular iron pools that differentially regulate expression of proteins such as ferritin and transferrin receptor (TfR)…”
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Cadmium-induced aggregation of iron regulatory protein-1 by Liu, Ying, Xiao, Weiqun, Templeton, Douglas M

“…Abstract Iron regulatory protein-1 (IRP-1) is central to regulation of iron homeostasis, and has been shown to be sensitive to Cd2+ in vitro. Although Cd2+…”
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Transport of iron chelators and chelates across MDCK cell monolayers: implications for iron excretion during chelation therapy by Huang, Xi-Ping, Thiessen, Jake J., Spino, Michael, Templeton, Douglas M.

“…Iron chelators are effective at removing iron from the body in iron overload, but little is known about the handling of iron chelates by the kidney. We studied…”
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Cadmium-induced glutathionylation of actin occurs through a ROS-independent mechanism: Implications for cytoskeletal integrity by Choong, Grace, Liu, Ying, Xiao, Weiqun, Templeton, Douglas M.

“…Cadmium disrupts the actin cytoskeleton in rat mesangial cells, and we have previously shown that this involves a complex interplay involving activation of…”
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Involvement of CaMK-IIδ and gelsolin in Cd(2+) -dependent cytoskeletal effects in mesangial cells by Liu, Ying, Templeton, Douglas M

“…Cadmium is a toxic metal with pleiotropic effects on cell death and survival. The mesangial cell is particularly responsive to Cd's effects on kinase signaling…”
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Cadmium activates CaMK-II and initiates CaMK-II-dependent apoptosis in mesangial cells by Liu, Ying, Templeton, Douglas M.

“…Cadmium is a toxic metal that initiates both mitogenic responses and cell death. We show that Cd2+ increases phosphorylation and activity of…”
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