Search Results - "Temple, Brenda R S"

G Protein-Coupled Receptor Sorting to Endosomes and Lysosomes by MARCHESE, Adriano, PAING, May M, TEMPLE, Brenda R. S, TREJO, Joann

“…The heptahelical G protein-coupled receptors (GPCRs) belong to the largest family of cell surface signaling receptors encoded in the human genome. GPCRs signal…”
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Differences in intradomain and interdomain motion confer distinct activation properties to structurally similar Gα proteins by Jones, Janice C, Jones, Alan M, Temple, Brenda R. S, Dohlman, Henrik G

“…Proteins with similar crystal structures can have dissimilar rates of substrate binding and catalysis. Here we used molecular dynamics simulations and…”
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Mechanisms of HIV-1 Nef Function and Intracellular Signaling by Foster, John L., Denial, Sarah J., Temple, Brenda R. S., Garcia, J. Victor

“…Advances in the last several years have enhanced mechanistic understanding of Nef-induced CD4 and MHCI downregulation and have suggested a new paradigm for…”
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AvrRpm1 missense mutations weakly activate RPS2-mediated immune response in Arabidopsis thaliana by Cherkis, Karen A, Temple, Brenda R S, Chung, Eui-Hwan, Sondek, John, Dangl, Jeffery L

“…Plants recognize microbes via specific pattern recognition receptors that are activated by microbe-associated molecular patterns (MAMPs), resulting in…”
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Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes by Siraliev-Perez, Edhriz, Stariha, Jordan T B, Hoffmann, Reece M, Temple, Brenda R S, Zhang, Qisheng, Hajicek, Nicole, Jenkins, Meredith L, Burke, John E, Sondek, John

“…Numerous receptor tyrosine kinases and immune receptors activate phospholipase C-γ (PLC-γ) isozymes at membranes to control diverse cellular processes…”
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Heterotrimeric G-protein signaling is critical to pathogenic processes in Entamoeba histolytica by Bosch, Dustin E, Kimple, Adam J, Muller, Robin E, Giguère, Patrick M, Machius, Mischa, Willard, Francis S, Temple, Brenda R S, Siderovski, David P

“…Heterotrimeric G-protein signaling pathways are vital components of physiology, and many are amenable to pharmacologic manipulation. Here, we identify…”
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Evolution and Virulence Contributions of the Autotransporter Proteins YapJ and YapK of Yersinia pestis CO92 and Their Homologs in Y. pseudotuberculosis IP32953 by LENZ, Jonathan D, TEMPLE, Brenda R. S, MILLERA, Virginia L

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Plant Heterotrimeric G-Protein Complex by Temple, B.R.S, Jones, A.M

“…Heterotrimeric G-protein complexes couple extracellular signals via cell surface receptors to downstream enzymes called effectors. Heterotrimeric G-protein…”
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Evolution of a signaling nexus constrained by protein interfaces and conformational States by Temple, Brenda R S, Jones, Corbin D, Jones, Alan M

“…Heterotrimeric G proteins act as the physical nexus between numerous receptors that respond to extracellular signals and proteins that drive the cytoplasmic…”
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Active nuclear receptors exhibit highly correlated AF-2 domain motions by Teotico, Denise G, Frazier, Monica L, Ding, Feng, Dokholyan, Nikolay V, Temple, Brenda R S, Redinbo, Matthew R

“…Nuclear receptor ligand binding domains (LBDs) convert ligand binding events into changes in gene expression by recruiting transcriptional coregulators to a…”
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Self-association of the Lentivirus protein, Nef by Kwak, Youn Tae, Raney, Alexa, Kuo, Lillian S, Denial, Sarah J, Temple, Brenda R S, Garcia, J Victor, Foster, John L

“…The HIV-1 pathogenic factor, Nef, is a multifunctional protein present in the cytosol and on membranes of infected cells. It has been proposed that a spatial…”
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Isoform Divergence of the Filamin Family of Proteins by Kesner, Barry A., Milgram, Sharon L., Temple, Brenda R.S., Dokholyan, Nikolay V.

“…The vertebrate filamin family (A, B, and C) is part of the spectrin family of actin cross-linking proteins. Family members share high sequence similarity…”
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KSHV Viral Protein Kinase Interacts with USP9X to Modulate the Viral Lifecycle by Chappell, Danielle L, Sandhu, Praneet K, Wong, Jason P, Bhatt, Aadra P, Liu, Xiaoxi, Buhrlage, Sara J, Temple, Brenda R S, Major, M Ben, Damania, Blossom

“…Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi sarcoma (KS), the plasmablastic form of multicentric Castleman's disease, and…”
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Functional conservation and divergence of the helix‐turn‐helix motif of E2 ubiquitin‐conjugating enzymes by Welsh, Kaeli A, Bolhuis, Derek L, Nederstigt, Anneroos E, Boyer, Joshua, Temple, Brenda R S, Bonacci, Thomas, Gu, Li, Ordureau, Alban, Harper, J Wade, Steimel, Joshua P, Zhang, Qi, Emanuele, Michael J, Harrison, Joseph S, Brown, Nicholas G

“…Polyubiquitination by E2 and E3 enzymes is crucial to cell cycle control, epigenetic regulation, and development. The hallmark of the E2 family is the…”
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Structural complexity and functional diversity of plant NADPH oxidases by Kaur, Gurpreet, Guruprasad, Kunchur, Temple, Brenda R. S., Shirvanyants, David G., Dokholyan, Nikolay V., Pati, Pratap Kumar

“…Plant NADPH oxidases also known as respiratory burst oxidase homologs (Rbohs) are a family of membrane-bound enzymes that play diverse roles in the defense…”
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The crystal structure of a self-activating G protein alpha subunit reveals its distinct mechanism of signal initiation by Jones, Janice C, Duffy, Jeffrey W, Machius, Mischa, Temple, Brenda R S, Dohlman, Henrik G, Jones, Alan M

“…In animals, heterotrimeric guanine nucleotide-binding protein (G protein) signaling is initiated by G protein-coupled receptors (GPCRs), which activate G…”
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Acireductone Dioxygenase 1 (ARD1) Is an Effector of the Heterotrimeric G Protein β Subunit in Arabidopsis by Friedman, Erin J., Wang, Helen X., Jiang, Kun, Perovic, Iva, Deshpande, Aditi, Pochapsky, Thomas C., Temple, Brenda R.S., Hicks, Stephanie N., Harden, T. Kendall, Jones, Alan M.

“…Heterotrimeric G protein complexes are conserved from plants to mammals, but the complexity of each system varies. Arabidopsis thaliana contains one Gα, one Gβ…”
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A viral kinase mimics S6 kinase to enhance cell proliferation by Bhatt, Aadra Prashant, Wong, Jason P., Weinberg, Marc S., Host, Kurtis M., Giffin, Louise C., Buijnink, Joshua, van Dijk, Evert, Izumiya, Yoshihiro, Kung, Hsing-jien, Temple, Brenda R. S., Damania, Blossom

“…Viruses depend upon the host cell for manufacturing components of progeny virions. To mitigate the inextricable dependence on host cell protein synthesis,…”
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Distinct self-interaction domains promote Multi Sex Combs accumulation in and formation of the Drosophila histone locus body by Terzo, Esteban A, Lyons, Shawn M, Poulton, John S, Temple, Brenda R S, Marzluff, William F, Duronio, Robert J

“…Nuclear bodies (NBs) are structures that concentrate proteins, RNAs, and ribonucleoproteins that perform functions essential to gene expression. How NBs…”
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A phosphatidylinositol transfer protein integrates phosphoinositide signaling with lipid droplet metabolism to regulate a developmental program of nutrient stress-induced membrane biogenesis by Ren, Jihui, Pei-Chen Lin, Coney, Pathak, Manish C, Temple, Brenda R S, Nile, Aaron H, Mousley, Carl J, Duncan, Mara C, Eckert, Debra M, Leiker, Thomas J, Ivanova, Pavlina T, Myers, David S, Murphy, Robert C, Brown, H Alex, Verdaasdonk, Jolien, Bloom, Kerry S, Ortlund, Eric A, Neiman, Aaron M, Bankaitis, Vytas A

“…Lipid droplet (LD) utilization is an important cellular activity that regulates energy balance and release of lipid second messengers. Because fatty acids…”
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