Search Results - "Temperton, Nigel"

Detection of Serum Cross-Reactive Antibodies and Memory Response to SARS-CoV-2 in Prepandemic and Post–COVID-19 Convalescent Samples by Shrwani, Khalid, Sharma, Ravi, Krishnan, Madhan, Jones, Terry, Mayora-Neto, Martin, Cantoni, Diego, Temperton, Nigel J, Dobson, Susan L, Subramaniam, Krishanthi, McNamara, Paul S, Cunliffe, Nigel A, Turtle, Lance, Zhang, Qibo

“…Abstract Background A notable feature of coronavirus disease 2019 (COVID-19) is that children are less susceptible to severe disease. Children are known to…”
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Characterisation of SARS-CoV-2 Lentiviral Pseudotypes and Correlation between Pseudotype-Based Neutralisation Assays and Live Virus-Based Micro Neutralisation Assays by Hyseni, Inesa, Molesti, Eleonora, Benincasa, Linda, Piu, Pietro, Casa, Elisa, Temperton, Nigel J, Manenti, Alessandro, Montomoli, Emanuele

“…The recent outbreak of a novel Coronavirus (SARS-CoV-2) and its rapid spread across the continents has generated an urgent need for assays to detect the…”
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Influenza hemagglutinin stem-fragment immunogen elicits broadly neutralizing antibodies and confers heterologous protection by Mallajosyula, Vamsee V A, Citron, Michael, Ferrara, Francesca, Lu, Xianghan, Callahan, Cheryl, Heidecker, Gwendolyn J, Sarma, Siddhartha P, Flynn, Jessica A, Temperton, Nigel J, Liang, Xiaoping, Varadarajan, Raghavan

“…Influenza hemagglutinin (HA) is the primary target of the humoral response during infection/vaccination. Current influenza vaccines typically fail to…”
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Potent cross-reactive antibodies following Omicron breakthrough in vaccinees by Nutalai, Rungtiwa, Zhou, Daming, Tuekprakhon, Aekkachai, Ginn, Helen M., Supasa, Piyada, Liu, Chang, Huo, Jiandong, Mentzer, Alexander J., Duyvesteyn, Helen M.E., Dijokaite-Guraliuc, Aiste, Skelly, Donal, Ritter, Thomas G., Amini, Ali, Bibi, Sagida, Adele, Sandra, Johnson, Sile Ann, Constantinides, Bede, Webster, Hermione, Temperton, Nigel, Klenerman, Paul, Barnes, Eleanor, Dunachie, Susanna J., Crook, Derrick, Pollard, Andrew J., Lambe, Teresa, Goulder, Philip, Paterson, Neil G., Williams, Mark A., Hall, David R., Mongkolsapaya, Juthathip, Fry, Elizabeth E., Dejnirattisai, Wanwisa, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.

“…Highly transmissible Omicron variants of SARS-CoV-2 currently dominate globally. Here, we compare neutralization of Omicron BA.1, BA.1.1, and BA.2. BA.2 RBD…”
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Induction of broad immunity by thermostabilised vaccines incorporated in dissolvable microneedles using novel fabrication methods by Vrdoljak, Anto, Allen, Evin A., Ferrara, Francesca, Temperton, Nigel J., Crean, Abina M., Moore, Anne C.

“…Dissolvable microneedle (DMN) patches for immunization have multiple benefits, including vaccine stability and ease-of-use. However, conventional DMN…”
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Humoral Immunogenicity and Efficacy of a Single Dose of ChAdOx1 MERS Vaccine Candidate in Dromedary Camels by Alharbi, Naif Khalaf, Qasim, Ibrahim, Almasoud, Abdulrahman, Aljami, Haya A., Alenazi, Mohamed W., Alhafufi, Ali, Aldibasi, Omar S., Hashem, Anwar M., Kasem, Samy, Albrahim, Raed, Aldubaib, Musaad, Almansour, Ali, Temperton, Nigel J., Kupke, Alexandra, Becker, Stephan, Abu-obaidah, Ali, Alkarar, Ali, Yoon, In-Kyu, Azhar, Esam, Lambe, Teresa, Bayoumi, Faisal, Aldowerij, Ali, Ibrahim, Osman H., Gilbert, Sarah C., Balkhy, Hanan H.

“…MERS-CoV seronegative and seropositive camels received a single intramuscular dose of ChAdOx1 MERS, a replication-deficient adenoviral vectored vaccine…”
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Llama-derived single domain antibodies to build multivalent, superpotent and broadened neutralizing anti-viral molecules by Hultberg, Anna, Temperton, Nigel J, Rosseels, Valérie, Koenders, Mireille, Gonzalez-Pajuelo, Maria, Schepens, Bert, Ibañez, Lorena Itatí, Vanlandschoot, Peter, Schillemans, Joris, Saunders, Michael, Weiss, Robin A, Saelens, Xavier, Melero, José A, Verrips, C Theo, Van Gucht, Steven, de Haard, Hans J

“…For efficient prevention of viral infections and cross protection, simultaneous targeting of multiple viral epitopes is a powerful strategy. Llama heavy chain…”
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Nanobodies mapped to cross-reactive and divergent epitopes on A(H7N9) influenza hemagglutinin using yeast display by Gaiotto, Tiziano, Ramage, Walter, Ball, Christina, Risley, Paul, Carnell, George W., Temperton, Nigel, Engelhardt, Othmar G., Hufton, Simon E.

“…Influenza H7N9 virus continues to cause infections in humans and represents a significant pandemic risk. During the most recent 5th epidemic wave in 2016/17…”
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Broad-spectrum CRISPR-mediated inhibition of SARS-CoV-2 variants and endemic coronaviruses in vitro by Zeng, Leiping, Liu, Yanxia, Nguyenla, Xammy Huu, Abbott, Timothy R., Han, Mengting, Zhu, Yanyu, Chemparathy, Augustine, Lin, Xueqiu, Chen, Xinyi, Wang, Haifeng, Rane, Draven A., Spatz, Jordan M., Jain, Saket, Rustagi, Arjun, Pinsky, Benjamin, Zepeda, Adrianna E., Kadina, Anastasia P., Walker, John A., Holden, Kevin, Temperton, Nigel, Cochran, Jennifer R., Barron, Annelise E., Connolly, Michael D., Blish, Catherine A., Lewis, David B., Stanley, Sarah A., La Russa, Marie F., Qi, Lei S.

“…A major challenge in coronavirus vaccination and treatment is to counteract rapid viral evolution and mutations. Here we demonstrate that CRISPR-Cas13d offers…”
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Development of immunohistochemistry and in situ hybridisation for the detection of SARS-CoV and SARS-CoV-2 in formalin-fixed paraffin-embedded specimens by Lean, Fabian Z. X., Lamers, Mart M., Smith, Samuel P., Shipley, Rebecca, Schipper, Debby, Temperton, Nigel, Haagmans, Bart L., Banyard, Ashley C., Bewley, Kevin R., Carroll, Miles W., Brookes, Sharon M., Brown, Ian, Nuñez, Alejandro

“…The rapid emergence of SARS-CoV-2, the causative agent of COVID-19, and its dissemination globally has caused an unprecedented strain on public health. Animal…”
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Serological analysis in humans in Malaysian Borneo suggests prior exposure to H5 avian influenza near migratory shorebird habitats by Klim, Hannah, William, Timothy, Mellors, Jack, Brady, Caolann, Rajahram, Giri S., Chua, Tock H., Brazal Monzó, Helena, John, Jecelyn Leslie, da Costa, Kelly, Jeffree, Mohammad Saffree, Temperton, Nigel J., Tipton, Tom, Thompson, Craig P., Ahmed, Kamruddin, Drakeley, Chris J., Carroll, Miles W., Fornace, Kimberly M.

“…Cases of H5 highly pathogenic avian influenzas (HPAI) are on the rise. Although mammalian spillover events are rare, H5N1 viruses have an estimated mortality…”
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Studying longitudinal neutralising antibody levels against Equid herpesvirus 1 in experimentally infected horses using a novel pseudotype based assay by Di Genova, Cecilia, Sutton, Gabrielle, Paillot, Romain, Temperton, Nigel, Pronost, Stéphane, Scott, Simon D.

“…•gB, gD, gH and gL glycoproteins are required and sufficient for EHV-1 PV cell entry.•EHV-1 specific antibodies are measurable in a pseudotype virus…”
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A transgenic mouse with a humanised B cell repertoire mounts an antibody response to influenza infection and vaccination by Murugaiah, V, Watson, S J, Cunliffe, R F, Temperton, N J, Reece, S T, Kellam, P, Tregoning, J S

“…The development of a universal influenza vaccine likely requires an understanding of previous exposure to influenza virus (through vaccination or infection)…”
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Lung directed antibody gene transfer confers protection against SARS-CoV-2 infection by Du, Yue, Miah, Kamran M, Habib, Omar, Meyer-Berg, Helena, Conway, Catriona C, Viegas, Mariana A, Dean, Rebecca, Satyapertiwi, Dwiantari, Zhao, Jincun, Wang, Yanqun, Temperton, Nigel J, Gamlen, Toby P E, Gill, Deborah R, Hyde, Stephen C

“…The COVID-19 pandemic continues to be a worldwide threat and effective antiviral drugs and vaccines are being developed in a joint global effort. However, some…”
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Isolation of infectious Lloviu virus from Schreiber’s bats in Hungary by Kemenesi, Gábor, Tóth, Gábor E., Mayora-Neto, Martin, Scott, Simon, Temperton, Nigel, Wright, Edward, Mühlberger, Elke, Hume, Adam J., Suder, Ellen L., Zana, Brigitta, Boldogh, Sándor A., Görföl, Tamás, Estók, Péter, Szentiványi, Tamara, Lanszki, Zsófia, Somogyi, Balázs A., Nagy, Ágnes, Pereszlényi, Csaba I., Dudás, Gábor, Földes, Fanni, Kurucz, Kornélia, Madai, Mónika, Zeghbib, Safia, Maes, Piet, Vanmechelen, Bert, Jakab, Ferenc

“…Some filoviruses can be transmitted to humans by zoonotic spillover events from their natural host and filovirus outbreaks have occured with increasing…”
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Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccine by Corti, Davide, Suguitan, Jr, Amorsolo L, Pinna, Debora, Silacci, Chiara, Fernandez-Rodriguez, Blanca M, Vanzetta, Fabrizia, Santos, Celia, Luke, Catherine J, Torres-Velez, Fernando J, Temperton, Nigel J, Weiss, Robin A, Sallusto, Federica, Subbarao, Kanta, Lanzavecchia, Antonio

“…The target of neutralizing antibodies that protect against influenza virus infection is the viral protein HA. Genetic and antigenic variation in HA has been…”
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The antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variants by Liu, Chang, Zhou, Daming, Nutalai, Rungtiwa, Duyvesteyn, Helen M.E., Tuekprakhon, Aekkachai, Ginn, Helen M., Dejnirattisai, Wanwisa, Supasa, Piyada, Mentzer, Alexander J., Wang, Beibei, Case, James Brett, Zhao, Yuguang, Skelly, Donal T., Chen, Rita E., Johnson, Sile Ann, Ritter, Thomas G., Mason, Chris, Malik, Tariq, Temperton, Nigel, Paterson, Neil G., Williams, Mark A., Hall, David R., Clare, Daniel K., Howe, Andrew, Goulder, Philip J.R., Fry, Elizabeth E., Diamond, Michael S., Mongkolsapaya, Juthathip, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.

“…Alpha-B.1.1.7, Beta-B.1.351, Gamma-P.1, and Delta-B.1.617.2 variants of SARS-CoV-2 express multiple mutations in the spike protein (S). These may alter the…”
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Mapping the interaction sites of human and avian influenza A viruses and complement factor H by Rabeeah, Iman, Billington, Elizabeth, Nal, Béatrice, Sadeyen, Jean-Remy, Pathan, Ansar A, Iqbal, Munir, Temperton, Nigel J, Zipfel, Peter F, Skerka, Christine, Kishore, Uday, Shelton, Holly

“…The complement system is an innate immune mechanism against microbial infections. It involves a cascade of effector molecules that is activated via classical,…”
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A naturally protective epitope of limited variability as an influenza vaccine target by Thompson, Craig P., Lourenço, José, Walters, Adam A., Obolski, Uri, Edmans, Matthew, Palmer, Duncan S., Kooblall, Kreepa, Carnell, George W., O’Connor, Daniel, Bowden, Thomas A., Pybus, Oliver G., Pollard, Andrew J., Temperton, Nigel J., Lambe, Teresa, Gilbert, Sarah C., Gupta, Sunetra

“…Current antigenic targets for influenza vaccine development are either highly immunogenic epitopes of high variability or conserved epitopes of low…”
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The use of pseudotypes to study viruses, virus sero-epidemiology and vaccination by Bentley, Emma M, Mather, Stuart T, Temperton, Nigel J

“…Abstract The globalization of the world's economies, accompanied by increasing international travel, changing climates, altered human behaviour and…”
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