Search Results - "Tempel, Dennie"

Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress by CHENG, Caroline, TEMPEL, Dennie, VAN HAPEREN, Rien, VAN DER BAAN, Arjen, GROSVELD, Frank, DAEMEN, Mat J. A. P, KRAMS, Rob, DE CROM, Rini

“…Atherosclerotic lesions are predominantly observed in curved arteries and near side branches, where low or oscillatory shear stress patterns occur, suggesting…”
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Oncostatin M: Risks and Benefits of a Novel Therapeutic Target for Atherosclerosis by Rankouhi, Tanja Rouhani, Keulen, Daniëlle van, Tempel, Dennie, Venhorst, Jennifer

“…Cardiovascular disease (CVD) is a leading cause of death worldwide. It is predicted that approximately 23.6 million people will die from CVDs annually by 2030…”
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Inflammatory cytokine oncostatin M induces endothelial activation in macro- and microvascular endothelial cells and in APOE3Leiden.CETP mice by van Keulen, Danielle, Pouwer, Marianne G, Pasterkamp, Gerard, van Gool, Alain J, Sollewijn Gelpke, Maarten D, Princen, Hans M G, Tempel, Dennie

“…Endothelial activation is involved in many chronic inflammatory diseases, such as atherosclerosis, and is often initiated by cytokines. Oncostatin M (OSM) is a…”
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Capture of circulatory endothelial progenitor cells and accelerated re-endothelialization of a bio-engineered stent in human ex vivo shunt and rabbit denudation model by Larsen, Katarína, Cheng, Caroline, Tempel, Dennie, Parker, Sherry, Yazdani, Saami, den Dekker, Wijnand K., Houtgraaf, Jaco H., de Jong, Renate, Swager-ten Hoor, Stijn, Ligtenberg, Erik, Hanson, Stephen R., Rowland, Steve, Kolodgie, Frank, Serruys, Patrick W., Virmani, Renu, Duckers, Henricus J.

“…Aims The Genous™ Bio-engineered R™ stent (GS) aims to promote vascular healing by capture of circulatory endothelial progenitor cells (EPCs) to the surface of…”
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Current outlook of cardiac stem cell therapy towards a clinical application by Takashima, Shin-Ichiro, Tempel, Dennie, Duckers, Henricus J

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Large variations in absolute wall shear stress levels within one species and between species by Cheng, Caroline, Helderman, Frank, Tempel, Dennie, Segers, Dolf, Hierck, Beerend, Poelmann, Rob, van Tol, Arie, Duncker, Dirk J, Robbers-Visser, Danielle, Ursem, Nicolette T.C, van Haperen, Rien, Wentzel, Jolanda J, Gijsen, Frank, van der Steen, Anton F.W, de Crom, Rini, Krams, Rob

“…Abstract Wall shear stress (WSS), the frictional force between blood and endothelium, is an important determinant of vascular function. It is generally assumed…”
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Oncostatin M reduces atherosclerosis development in APOE3Leiden.CETP mice and is associated with increased survival probability in humans by Keulen, Danielle van, Pouwer, Marianne G, Emilsson, Valur, Matic, Ljubica Perisic, Pieterman, Elsbet J, Hedin, Ulf, Gudnason, Vilmundur, Jennings, Lori L, Holmstrøm, Kim, Nielsen, Boye Schnack, Pasterkamp, Gerard, Lindeman, Jan H N, van Gool, Alain J, Sollewijn Gelpke, Maarten D, Princen, Hans M G, Tempel, Dennie

“…Previous studies indicate a role for Oncostatin M (OSM) in atherosclerosis and other chronic inflammatory diseases for which inhibitory antibodies are in…”
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Endothelial Cell―Specific FGD5 Involvement in Vascular Pruning Defines Neovessel Fate in Mice by CHENG, Caroline, HAASDIJK, Remco, CHRIFI, Ihsan, BIESSEN, Erik A. L, DIMMELER, Stefanie, SCHULTE-MERKER, Stefan, DUCKERS, Henricus J, TEMPEL, Dennie, VAN DE KAMP, Esther H. M, HERPERS, Robert, BOS, Frank, DEN DEKKER, Wijnand K, BLONDEN, Lau A. J, DE JONG, Renate, BURGISSER, Petra E

“…New vessel formation contributes to organ development during embryogenesis and tissue repair in response to mechanical damage, inflammation, and ischemia in…”
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Shear stress affects the intracellular distribution of eNOS: direct demonstration by a novel in vivo technique by Cheng, Caroline, van Haperen, Rien, de Waard, Monique, van Damme, Luc C.A., Tempel, Dennie, Hanemaaijer, Laurens, van Cappellen, Gert W.A., Bos, Joop, Slager, Cornelis J., Duncker, Dirk J., van der Steen, Anton F.W., de Crom, Rini, Krams, Rob

“…The focal location of atherosclerosis in the vascular tree is correlated with local variations in shear stress. We developed a method to induce defined…”
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Time course of VCAM-1 expression in reperfused myocardial infarction in swine and its relation to retention of intracoronary administered bone marrow-derived mononuclear cells by Uitterdijk, André, Groenendijk, Bianca C W, Gorsse-Bakker, Charlotte, Panasewicz, Anna, Sneep, Stefan, Tempel, Dennie, van de Kamp, Esther H, Merkus, Daphne, van der Giessen, Willem J, Duncker, Dirk J

“…Intracoronary infusion of autologous bone marrow-derived mononuclear cells (BMMNC), after acute myocardial infarction (AMI), has been shown to improve…”
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Beneficial effects of exercise training after myocardial infarction require full eNOS expression by de Waard, Monique C, van Haperen, Rien, Soullié, Thomas, Tempel, Dennie, de Crom, Rini, Duncker, Dirk J

“…Abstract Exercise training attenuates left ventricular (LV) dysfunction after myocardial infarction (MI). It could be speculated that these effects of exercise…”
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Integrated Human Evaluation of the Lysophosphatidic Acid Pathway as a Novel Therapeutic Target in Atherosclerosis by Aldi, Silvia, Matic, Ljubica Perisic, Hamm, Gregory, van Keulen, Daniëlle, Tempel, Dennie, Holmstrøm, Kim, Szwajda, Agnieszka, Nielsen, Boye Schnack, Emilsson, Valur, Ait-Belkacem, Rima, Lengquist, Mariette, Paulsson-Berne, Gabrielle, Eriksson, Per, Lindeman, Jan H.N., Gool, Alain J., Stauber, Jonathan, Hedin, Ulf, Hurt-Camejo, Eva

“…Variants in the PLPP3 gene encoding for lipid phosphate phosphohydrolase 3 have been associated with susceptibility to atherosclerosis independently of…”
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Common Variants Associated With OSMR Expression Contribute to Carotid Plaque Vulnerability, but Not to Cardiovascular Disease in Humans by van Keulen, Danielle, van Koeverden, Ian D, Boltjes, Arjan, Princen, Hans M G, van Gool, Alain J, de Borst, Gert J, Asselbergs, Folkert W, Tempel, Dennie, Pasterkamp, Gerard, van der Laan, Sander W

“…Oncostatin M (OSM) signaling is implicated in atherosclerosis, however the mechanism remains unclear. We investigated the impact of common genetic variants in…”
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Feasibility of intracoronary GLP-1 eluting CellBead™ infusion in acute myocardial infarction by Houtgraaf, Jaco H, de Jong, Renate, Monkhorst, Kim, Tempel, Dennie, van de Kamp, Esther, den Dekker, Wijnand K, Kazemi, Kushan, Hoefer, Imo, Pasterkamp, Gerard, Lewis, Andrew L, Stratford, Peter W, Wallrapp, Christine, Zijlstra, Felix, Duckers, Henricus J

“…Cell therapy is a field of growing interest in the prevention of post acute myocardial infarction (AMI) heart failure. Stem cell retention upon local delivery…”
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Atherosclerotic Plaque Stability Is Affected by the Chemokine CXCL10 in Both Mice and Humans by Segers, Dolf, Lipton, Jonathan A., Leenen, Pieter J. M., Cheng, Caroline, Tempel, Dennie, Pasterkamp, Gerard, Moll, Frans L., de Crom, Rini, Krams, Rob

“…Background. The chemokine CXCL10 is specifically upregulated during experimental development of plaque with an unstable phenotype. In this study we evaluated…”
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Response to Letter Regarding Article, “Atherosclerotic Lesion Size and Vulnerability Are Determined by Patterns of Fluid Shear Stress” by Cheng, Caroline, Tempel, Dennie, van der Baan, Arjen, Krams, Rob, Daemen, Mat J.A. P., van Haperen, Rien, Grosveld, Frank, de Crom, Rini

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Use of Merlin Assay to identify patients with a low-risk for SN metastasis in a prospective multicenter Dutch study of a primary melanoma gene-signature (CP-GEP model) to predict sentinel node status during COVID-19 by Stassen, Robert, Mulder, Evalyn, Veringa, Antoine, Mooyaart, Antien, Dwarkasing, Jvalini, Tempel, Dennie, van der Hage, Jos A., Lendfers, Sandra, Aarts, Maureen J.B., Verhoef, Cornelis, Francken, Anne Brecht, Grunhagen, Dirk J.

“…9571 Background: Approximately 70%-85% of patients who undergo sentinel lymph node biopsy (SLNb) show no nodal metastasis in the sentinel node (SN). The…”
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Activation of CECR1 in M2-like TAMs promotes paracrine stimulation-mediated glial tumor progression by Zhu, Changbin, Mustafa, Dana, Zheng, Ping-Pin, van der Weiden, Marcel, Sacchetti, Andrea, Brandt, Maarten, Chrifi, Ihsan, Tempel, Dennie, Leenen, Pieter J M, Duncker, Dirk Jan, Cheng, Caroline, Kros, Johan M

“…The majority of glioma-associated microglia/macrophages have been identified as M2-type macrophages with immune suppressive and tumor supportive action…”
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Bridging a diagnostic Kawasaki disease classifier from a microarray platform to a qRT-PCR assay by Kuiper, Rowan, Wright, Victoria J., Habgood-Coote, Dominic, Shimizu, Chisato, Huigh, Daphne, Tremoulet, Adriana H., van Keulen, Danielle, Hoggart, Clive J., Rodriguez-Manzano, Jesus, Herberg, Jethro A., Kaforou, Myrsini, Tempel, Dennie, Burns, Jane C., Levin, Michael

“…Background Kawasaki disease (KD) is a systemic vasculitis that mainly affects children under 5 years of age. Up to 30% of patients develop coronary artery…”
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Using a clinicopathologic and gene expression (CP-GEP) model to identify stage I-II melanoma patients at risk for disease relapse by Mulder, Evalyn, Johansson, Iva, Grünhagen, Dirk, Tempel, Dennie, Rentroia-Pacheco, Barbara, Dwarkasing, Jvalini, Verver, Daniëlle, Mooyaart, Antien, van der Veldt, Astrid, Nijsten, Tamar, Verhoef, Cornelis, Mattsson, Jan, Ny, Lars, Hollestein, Loes, Bagge, Roger Olofsson

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