Search Results - "Temel, Ryan"

ABCG5 and ABCG8: more than a defense against xenosterols by Patel, Shailendra B, Graf, Gregory A, Temel, Ryan E

“…The elucidation of the molecular basis of the rare disease, sitosterolemia, has revolutionized our mechanistic understanding of how dietary sterols are…”
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Hepatic or intestinal ABCG5 and ABCG8 are sufficient to block the development of sitosterolemia1 by Temel, Ryan

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A new model of reverse cholesterol transport: enTICEing strategies to stimulate intestinal cholesterol excretion by Temel, Ryan E, Brown, J. Mark

“…Highlights • RCT involves both biliary and non-biliary pathways. • The non-biliary pathway normally constitutes ∼30% of RCT, but it can be stimulated. • Flux…”
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Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis by Rayner, Katey J, Sheedy, Frederick J, Esau, Christine C, Hussain, Farah N, Temel, Ryan E, Parathath, Saj, van Gils, Janine M, Rayner, Alistair J, Chang, Aaron N, Suarez, Yajaira, Fernandez-Hernando, Carlos, Fisher, Edward A, Moore, Kathryn J

“…Plasma HDL levels have a protective role in atherosclerosis, yet clinical therapies to raise HDL levels have remained elusive. Recent advances in the…”
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Research Advances in Abdominal Aortic Aneurysms: Triglyceride-Rich Lipoproteins as a Therapeutic Target by Lu, Hong S, Temel, Ryan E, Levin, Michael G, Damrauer, Scott M, Daugherty, Alan

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Stigmasterol stimulates transintestinal cholesterol excretion independent of liver X receptor activation in the small intestine by Lifsey, Hannah C., Kaur, Rupinder, Thompson, Bradley H, Bennett, Lisa, Temel, Ryan E., Graf, Gregory A.

“…Despite advances in healthcare, cardiovascular disease (CVD) remains the leading cause of death in the United States. Elevated levels of plasma cholesterol are…”
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XX sex chromosome complement promotes atherosclerosis in mice by AlSiraj, Yasir, Chen, Xuqi, Thatcher, Sean E., Temel, Ryan E., Cai, Lei, Blalock, Eric, Katz, Wendy, Ali, Heba M., Petriello, Michael, Deng, Pan, Morris, Andrew J., Wang, Xuping, Lusis, Aldons J., Arnold, Arthur P., Reue, Karen, Thompson, Katherine, Tso, Patrick, Cassis, Lisa A.

“…Men and women differ in circulating lipids and coronary artery disease (CAD). While sex hormones such as estrogens decrease CAD risk, hormone replacement…”
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Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides by Rayner, Katey J., Esau, Christine C., Hussain, Farah N., McDaniel, Allison L., Marshall, Stephanie M., van Gils, Janine M., Ray, Tathagat D., Sheedy, Frederick J., Goedeke, Leigh, Liu, Xueqing, Khatsenko, Oleg G., Kaimal, Vivek, Lees, Cynthia J., Fernandez-Hernando, Carlos, Fisher, Edward A., Temel, Ryan E., Moore, Kathryn J.

“…Manipulating plasma lipids Recent work in mice has shown that microRNA-33a is an important regulator of lipid metabolism and that its inhibition can increase…”
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Biliary and nonbiliary contributions to reverse cholesterol transport by Temel, Ryan E., Brown, J. Mark

“…The process of reverse cholesterol transport (RCT) is critical for disposal of excess cholesterol from the body. Although it is generally accepted that RCT…”
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Paradoxical Suppression of Atherosclerosis in the Absence of microRNA-146a by Cheng, Henry S., Besla, Rickvinder, Li, Angela, Chen, Zhiqi, Shikatani, Eric A., Nazari-Jahantigh, Maliheh, Hammoutène, Adel, Nguyen, My-Anh, Geoffrion, Michele, Cai, Lei, Khyzha, Nadiya, Li, Tong, MacParland, Sonya A., Husain, Mansoor, Cybulsky, Myron I., Boulanger, Chantal M., Temel, Ryan E., Schober, Andreas, Rayner, Katey J., Robbins, Clinton S., Fish, Jason E.

“…RATIONALE:Inflammation is a key contributor to atherosclerosis. MicroRNA-146a (miR-146a) has been identified as a critical brake on proinflammatory nuclear…”
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Cholesterol and Lipoprotein Metabolism: Early Career Committee Contribution by Zhang, Hanrui, Temel, Ryan E, Martel, Catherine

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BMP7 Drives Human Adipogenic Stem Cells into Metabolically Active Beige Adipocytes by Okla, Meshail, Ha, Jung-Heun, Temel, Ryan E., Chung, Soonkyu

“…Adult humans have a substantial amount of inducible-brown (or beige) fat, which is associated with increased energy expenditure and reduced weight gain via…”
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The prorenin receptor and its soluble form contribute to lipid homeostasis by Gatineau, Eva, Arthur, Gertrude, Poupeau, Audrey, Nichols, Kellea, Spear, Brett T, Shelman, Nathan R, Graf, Gregory A, Temel, Ryan E, Yiannikouris, Frédérique B

“…Obesity is associated with alterations in hepatic lipid metabolism. We previously identified the prorenin receptor (PRR) as a potential contributor to liver…”
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Macrophage angiotensin-converting enzyme reduces atherosclerosis by increasing peroxisome proliferator-activated receptor α and fundamentally changing lipid metabolism by Cao, DuoYao, Khan, Zakir, Li, Xiaomo, Saito, Suguru, Bernstein, Ellen A, Victor, Aaron R, Ahmed, Faizan, Hoshi, Aoi O, Veiras, Luciana C, Shibata, Tomohiro, Che, Mingtian, Cai, Lei, Yamashita, Michifumi, Temel, Ryan E, Giani, Jorge F, Luthringer, Daniel J, Divakaruni, Ajit S, Okwan-Duodu, Derick, Bernstein, Kenneth E

“…Abstract Aims The metabolic failure of macrophages to adequately process lipid is central to the aetiology of atherosclerosis. Here, we examine the role of…”
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Association of NOTCH3 With Elastic Fiber Dispersion in the Infrarenal Abdominal Aorta of Cynomolgus Monkeys by Ito, Sohei, Amioka, Naofumi, Franklin, Michael K, Wang, Pengjun, Liang, Ching-Ling, Katsumata, Yuriko, Cai, Lei, Temel, Ryan E, Daugherty, Alan, Lu, Hong S, Sawada, Hisashi

“…The regional heterogeneity of vascular components and transcriptomes is an important determinant of aortic biology. This notion has been explored in multiple…”
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Surface Engineered Polymersomes for Enhanced Modulation of Dendritic Cells During Cardiovascular Immunotherapy by Yi, Sijia, Zhang, Xiaohan, Sangji, M. Hussain, Liu, Yugang, Allen, Sean D., Xiao, Baixue, Bobbala, Sharan, Braverman, Cameron L., Cai, Lei, Hecker, Peter I., DeBerge, Matthew, Thorp, Edward B., Temel, Ryan E., Stupp, Samuel I., Scott, Evan A.

“…The principle cause of cardiovascular disease (CVD) is atherosclerosis, a chronic inflammatory condition characterized by immunologically complex fatty lesions…”
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The LXR–Idol Axis Differentially Regulates Plasma LDL Levels in Primates and Mice by Hong, Cynthia, Marshall, Stephanie M., McDaniel, Allison L., Graham, Mark, Layne, Joseph D., Cai, Lei, Scotti, Elena, Boyadjian, Rima, Kim, Jason, Chamberlain, Brian T., Tangirala, Rajendra K., Jung, Michael E., Fong, Loren, Lee, Richard, Young, Stephen G., Temel, Ryan E., Tontonoz, Peter

“…The LXR-regulated E3 ubiquitin ligase IDOL controls LDLR receptor stability independent of SREBP and PCSK9, but its relevance to plasma lipid levels is…”
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Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin by Owens, 3rd, A Phillip, Passam, Freda H, Antoniak, Silvio, Marshall, Stephanie M, McDaniel, Allison L, Rudel, Lawrence, Williams, Julie C, Hubbard, Brian K, Dutton, Julie-Ann, Wang, Jianguo, Tobias, Peter S, Curtiss, Linda K, Daugherty, Alan, Kirchhofer, Daniel, Luyendyk, James P, Moriarty, Patrick M, Nagarajan, Shanmugam, Furie, Barbara C, Furie, Bruce, Johns, Douglas G, Temel, Ryan E, Mackman, Nigel

“…Hypercholesterolemia is a major risk factor for atherosclerosis. It also is associated with platelet hyperactivity, which increases morbidity and mortality…”
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The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance by Warrier, Manya, Shih, Diana M., Burrows, Amy C., Ferguson, Daniel, Gromovsky, Anthony D., Brown, Amanda L., Marshall, Stephanie, McDaniel, Allison, Schugar, Rebecca C., Wang, Zeneng, Sacks, Jessica, Rong, Xin, Vallim, Thomas de Aguiar, Chou, Jeff, Ivanova, Pavlina T., Myers, David S., Brown, H. Alex, Lee, Richard G., Crooke, Rosanne M., Graham, Mark J., Liu, Xiuli, Parini, Paolo, Tontonoz, Peter, Lusis, Aldon J., Hazen, Stanley L., Temel, Ryan E., Brown, J. Mark

“…Circulating levels of the gut microbe-derived metabolite trimethylamine-N-oxide (TMAO) have recently been linked to cardiovascular disease (CVD) risk. Here, we…”
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Targeting hepatic heparin-binding EGF-like growth factor (HB-EGF) induces anti-hyperlipidemia leading to reduction of angiotensin II-induced aneurysm development by Kim, Seonwook, Yang, Lihua, Kim, Seongu, Lee, Richard G, Graham, Mark J, Berliner, Judith A, Lusis, Aldons J, Cai, Lei, Temel, Ryan E, Rateri, Debra L, Lee, Sangderk

“…The upregulated expression of heparin binding EGF-like growth factor (HB-EGF) in the vessel and circulation is associated with risk of cardiovascular disease…”
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