Search Results - "Telugu, Bhanu P."

Engineering large animal models of human disease by Whitelaw, C Bruce A, Sheets, Timothy P, Lillico, Simon G, Telugu, Bhanu P

“…The recent development of gene editing tools and methodology for use in livestock enables the production of new animal disease models. These tools facilitate…”
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Author Correction: CRISPR-mediated editing of β-lactoglobulin (BLG) gene in buffalo by Tara, Aseem, Singh, Priyanka, Gautam, Devika, Tripathi, Gaurav, Uppal, Chirag, Malhotra, Shreya, De, Sacchinandan, Singh, Manoj K., Telugu, Bhanu P., Selokar, Naresh L.

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CRISPR-mediated editing of β-lactoglobulin (BLG) gene in buffalo by Tara, Aseem, Singh, Priyanka, Gautam, Devika, Tripathi, Gaurav, Uppal, Chirag, Malhotra, Shreya, De, Sacchinandan, Singh, Manoj K., Telugu, Bhanu P., Selokar, Naresh L.

“…Milk is a good source of nutrition but is also a source of allergenic proteins such as α-lactalbumin, β-lactoglobulin (BLG), casein, and immunoglobulins. The…”
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Generation of germline ablated male pigs by CRISPR/Cas9 editing of the NANOS2 gene by Park, Ki-Eun, Kaucher, Amy V., Powell, Anne, Waqas, Muhammad Salman, Sandmaier, Shelley E.S., Oatley, Melissa J., Park, Chi-Hun, Tibary, Ahmed, Donovan, David M., Blomberg, Le Ann, Lillico, Simon G., Whitelaw, C. Bruce A., Mileham, Alan, Telugu, Bhanu P., Oatley, Jon M.

“…Genome editing tools have revolutionized the generation of genetically modified animals including livestock. In particular, the domestic pig is a proven model…”
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Targeted Mutation of NGN3 Gene Disrupts Pancreatic Endocrine Cell Development in Pigs by Sheets, Timothy P., Park, Ki-Eun, Park, Chi-Hun, Swift, Steven M., Powell, Anne, Donovan, David M., Telugu, Bhanu P.

“…The domestic pig is an attractive model for biomedical research because of similarities in anatomy and physiology to humans. However, key gaps remain in our…”
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Generation of SOX2ZsGreen reporter authentic porcine induced pluripotent stem cells by Reddy Yeddula, Sai Goutham, Green, Erin, Sandmaeir, Shelly, Jeoung, Young-Hee, Subramanyam, Pradeep Nag, Park, Chi-Hun, Telugu, Bhanu P.

“…The transcription factor SOX2 plays a crucial role in pluripotency during embryogenesis. In this study, we successfully generated porcine induced pluripotent…”
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Targeted gene knock-in by CRISPR/Cas ribonucleoproteins in porcine zygotes by Park, Ki-Eun, Powell, Anne, Sandmaier, Shelley E. S., Kim, Chan-Mi, Mileham, Alan, Donovan, David M., Telugu, Bhanu P.

“…The domestic pig is an important “dual purpose” animal model for agricultural and biomedical applications. There is an emerging consensus in the biomedical…”
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Somatic Cell Nuclear Transfer Followed by CRIPSR/Cas9 Microinjection Results in Highly Efficient Genome Editing in Cloned Pigs by Sheets, Timothy P, Park, Chi-Hun, Park, Ki-Eun, Powell, Anne, Donovan, David M, Telugu, Bhanu P

“…The domestic pig is an ideal "dual purpose" animal model for agricultural and biomedical research. With the availability of genome editing tools such as…”
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Genome-wide recombination map construction from single sperm sequencing in cattle by Yang, Liu, Gao, Yahui, Li, Mingxun, Park, Ki-Eun, Liu, Shuli, Kang, Xiaolong, Liu, Mei, Oswalt, Adam, Fang, Lingzhao, Telugu, Bhanu P, Sattler, Charles G, Li, Cong-Jun, Cole, John B, Seroussi, Eyal, Xu, Lingyang, Yang, Lv, Zhou, Yang, Li, Li, Zhang, Hongping, Rosen, Benjamin D, Van Tassell, Curtis P, Ma, Li, Liu, George E

“…Meiotic recombination is one of the important phenomena contributing to gamete genome diversity. However, except for human and a few model organisms, it is not…”
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Improvements in pig agriculture through gene editing by Whitworth, Kristin M, Green, Jonathan A, Redel, Bethany K, Geisert, Rodney D, Lee, Kiho, Telugu, Bhanu P, Wells, Kevin D, Prather, Randall S

“…Genetic modification of animals via selective breeding is the basis for modern agriculture. The current breeding paradigm however has limitations, chief among…”
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Generation of induced pluripotent stem cells from domestic goats by Sandmaier, Shelley E. S., Nandal, Anjali, Powell, Anne, Garrett, Wesley, Blomberg, Leann, Donovan, David M., Talbot, Neil, Telugu, Bhanu P.

“…SUMMARY The creation of genetically modified goats provides a powerful approach for improving animal health, enhancing production traits, animal pharming, and…”
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Establishment, characterization, and validation of novel porcine embryonic fibroblasts as a potential source for genetic modification by Park, Chi-Hun, Jeoung, Young-Hee, Zhang, Luhui, Yeddula, Sai Goutham Reddy, Park, Ki-Eun, Waters, Jerel, Telugu, Bhanu P.

“…Fibroblasts are the common cell type in the connective tissue-the most abundant tissue type in the body. Fibroblasts are widely used for cell culture, for the…”
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Pigs lacking TMPRSS2 displayed fewer lung lesions and reduced inflammatory response when infected with influenza A virus by Ciacci Zanella, Giovana, Snyder, Celeste A, Arruda, Bailey L, Whitworth, Kristin, Green, Erin, Poonooru, Ravikanth Reddy, Telugu, Bhanu P, Baker, Amy L

“…Influenza A virus (IAV) infection is initiated by hemagglutinin (HA), a glycoprotein exposed on the virion's lipid envelope that undergoes cleavage by host…”
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Efficient DNA knock-in using AAV-mediated delivery with 2-cell embryo CRISPR-Cas9 electroporation by Davis, Daniel J, McNew, James F, Maresca-Fichter, Hailey, Chen, Kaiwen, Telugu, Bhanu P, Bryda, Elizabeth C

“…Recent advances in CRISPR-Cas genome editing technology have been instrumental in improving the efficiency to produce genetically modified animal models. In…”
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Targeted Gene Knockin in Porcine Somatic Cells Using CRISPR/Cas Ribonucleoproteins by Park, Ki-Eun, Park, Chi-Hun, Powell, Anne, Martin, Jessica, Donovan, David M, Telugu, Bhanu P

“…The pig is an ideal large animal model for genetic engineering applications. A relatively short gestation interval and large litter size makes the pig a…”
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Sexual dimorphism of mitochondrial function in the hypoxic guinea pig placenta by Song, Hong, Telugu, Bhanu P, Thompson, Loren P

“…Placental hypoxia can stimulate oxidative stress and mitochondrial dysfunction reducing placental efficiency and inducing fetal growth restriction (FGR). We…”
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Blastocyst complementation generates exogenous donor‐derived liver in ahepatic pigsc by Simpson, Sean G., Park, Ki‐Eun, Yeddula, Sai Gautham Reddy, Waters, Jerel, Scimeca, Erin, Poonooru, Ravikanth Reddy, Etches, Rob, Telugu, Bhanu P.

“…Liver diseases are one of the leading causes of morbidity and mortality worldwide. Globally, liver diseases are responsible for approximately 2 million deaths…”
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Development of Polarity-Reversed Endometrial Epithelial Organoids by Ahmad, Vakil, Yeddula, Sai Goutham Reddy, Telugu, Bhanu, Spencer, Thomas E, Kelleher, Andrew M

“…The uterine epithelium is composed of a single layer of hormone responsive polarized epithelial cells that line the lumen and form tubular glands. Endometrial…”
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Genome editing and genetic engineering in livestock for advancing agricultural and biomedical applications by Telugu, Bhanu P., Park, Ki-Eun, Park, Chi-Hun

“…Genetic modification of livestock has a longstanding and successful history, starting with domestication several thousand years ago. Modern animal breeding…”
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Placental Hypoxia During Early Pregnancy Causes Maternal Hypertension and Placental Insufficiency in the Hypoxic Guinea Pig Model by Thompson, Loren P, Pence, Laramie, Pinkas, Gerald, Song, Hong, Telugu, Bhanu P

“…Chronic placental hypoxia is one of the root causes of placental insufficiencies that result in pre-eclampsia and maternal hypertension. Chronic hypoxia causes…”
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