Search Results - "Tellez Freitas, Claudia M."
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Meta-Analysis of Two Human RNA-seq Datasets to Determine Periodontitis Diagnostic Biomarkers and Drug Target Candidates
Published in International journal of molecular sciences (17-05-2022)“…Periodontitis is a chronic inflammatory oral disease that affects approximately 42% of adults 30 years of age or older in the United States. In response to…”
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T Cell Calcium Signaling Regulation by the Co-Receptor CD5
Published in International journal of molecular sciences (26-04-2018)“…Calcium influx is critical for T cell effector function and fate. T cells are activated when T cell receptors (TCRs) engage peptides presented by…”
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Naïve helper T cells with high CD5 expression have increased calcium signaling
Published in PloS one (31-05-2017)“…The adaptive immune response is orchestrated by T helper cells and their function is dependent upon interactions between the T cell receptor (TCR), peptide MHC…”
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4
The nuclear variant of bone morphogenetic protein 2 (nBMP2) is expressed in macrophages and alters calcium response
Published in Scientific reports (30-01-2019)“…We previously identified a nuclear variant of bone morphogenetic protein 2 (BMP2), named nBMP2, that is translated from an alternative start codon. Decreased…”
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CD5 Deficiency Alters Helper T Cell Metabolic Function and Shifts the Systemic Metabolome
Published in Biomedicines (18-03-2022)“…Metabolic function plays a key role in immune cell activation, destruction of foreign pathogens, and memory cell generation. As T cells are activated, their…”
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Adverse effects of E‐cigarettes on head, neck, and oral cells: A systematic review
Published in Journal of oral pathology & medicine (01-02-2022)“…Background E‐cigarette sales in the United States (US) are projected to reach 16.5 billion by 2024 according to market analysis. Six deaths and 450 lung…”
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Common gut microbial metabolites of dietary flavonoids exert potent protective activities in β-cells and skeletal muscle cells
Published in The Journal of nutritional biochemistry (01-12-2018)“…Flavonoids are dietary compounds with potential anti-diabetes activities. Many flavonoids have poor bioavailability and thus low circulating concentrations…”
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Atypical chemokine receptor ACKR2-V41A has decreased CCL2 binding, scavenging, and activation, supporting sustained inflammation and increased Alzheimer’s disease risk
Published in Scientific reports (15-05-2020)“…A recent genome-wide association study (GWAS) of 59 cerebrospinal fluid (CSF) proteins with a connection to Alzheimer’s disease (AD) demonstrated an…”
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Hypoxanthine Guanine Phosphoribosyltransferase expression is negatively correlated with immune activity through its regulation of purine synthesis
Published in Immunobiology (1979) (01-05-2020)“…The purpose of this study was to examine the effects of elevated Hypoxanthine Guanine Phosphoribosyltransferase (HPRT) on the immune response in the tumor…”
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Synthetic Pharmacotherapy for Systemic Lupus Erythematosus: Potential Mechanisms of Action, Efficacy, and Safety
Published in Medicina (Kaunas, Lithuania) (27-12-2022)“…The pharmacological treatment of systemic lupus erythematosus (SLE) aims to decrease disease activity, progression, systemic compromise, and mortality. Among…”
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Immunomodulatory role of oral microbiota in inflammatory diseases and allergic conditions
Published in Frontiers in allergy (17-02-2023)“…In recent years, the interplay between oral microbiota and systemic disease has gained attention as poor oral health is associated with several pathologies…”
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Alphaviruses: Host pathogenesis, immune response, and vaccine & treatment updates
Published in Journal of general virology (26-08-2021)“…Human pathogens belonging to the Alphavirus genus, in the Togaviridae family, are transmitted primarily by mosquitoes. The signs and symptoms associated with…”
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Abstract 2369: HPRT overexpression may contribute to the immunosuppressive tumor microenvironment
Published in Cancer research (Chicago, Ill.) (01-07-2019)“…The purpose of this study was to examine the possible effects that Hypoxanthine Guanine Phosphoribosyltransferase (HPRT) may have on the immune response in the…”
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COVID-19: Ramifications and Effects on University Healthcare Students
Published in The journal of contemporary dental practice (01-09-2022)“…This study was carefully designed to analyze the perceived psychological impact of the COVID-19 pandemic among Roseman dental students. Students assessed their…”
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