Search Results - "Tekwani, B L"

Assay of β-hematin formation by malaria parasite by Pandey, A.V, Singh, N, Tekwani, B.L, Puri, S.K, Chauhan, V.S

“…Novel leads are urgently required for designing antimalarials due to the reduced efficacy of presently available drugs. The malaria parasite has a unique…”
Get full text

A Colorimetric Assay for Heme in Biological Samples Using 96-Well Plates by Pandey, A.V., Joshi, S.K., Tekwani, B.L., Chauhan, V.S.

Get full text

Molecular basis of defence against oxidative stress in Entamoeba histolytica and Giardia lamblia by Tekwani, Babu L, Mehlotra, Rajeev K

“…Gastrointestinal protozoa, viz. Entamoeba histolytica and Giardia, are able to survive in a microaerobic environment. The role of parasitic factors,…”
Get full text

Three New Manzamine Alkaloids from a Common Indonesian Sponge and Their Activity against Infectious and Tropical Parasitic Diseases by Rao, Karumanchi V, Kasanah, Noer, Wahyuono, Subagus, Tekwani, Babu L, Schinazi, Raymond F, Hamann, Mark T

“…Three new manzamine-type alkaloids, 12,34-oxamanzamine E (3), 8-hydroxymanzamine J (4), and 6-hydroxymanzamine E (8), as well as 12 previously characterized…”
Get full text

New Manzamine Alkaloids with Activity against Infectious and Tropical Parasitic Diseases from an Indonesian Sponge by Rao, Karumanchi V, Santarsiero, Bernard D, Mesecar, Andrew D, Schinazi, Raymond F, Tekwani, Babu L, Hamann, Mark T

“…Eleven manzamine type alkaloids, two β-carbolines, and five nucleosides have been isolated from an Indonesian sponge. Among these are the previously…”
Get full text

Artemisinin, an endoperoxide antimalarial, disrupts the hemoglobin catabolism and heme detoxification systems in malarial parasite by Pandey, A.V, Tekwani, B.L, Singh, R.L, Chauhan, V.S

“…Endoperoxide antimalarials based on the ancient Chinese drug Qinghaosu (artemisinin) are currently our major hope in the fight against drug-resistant malaria…”
Get full text

Targeting the hemozoin synthesis pathway for new antimalarial drug discovery: technologies for in vitro beta-hematin formation assay by Tekwani, Babu L, Walker, Larry A

“…Clinical manifestations of malaria primarily result from proliferation of the parasite within the hosts' erythrocytes. During this process, hemoglobin is…”
Get more information

Evaluation of the antimalarial and antileishmanial activity of plants from the Greek island of Crete by Fokialakis, N, Kalpoutzakis, E, Tekwani, B.L, Khan, S.I, Kobaisy, M, Skaltsounis, A.L, Duke, S.O

“…Different parts of 65 plant species from the Greek island of Crete have been extracted and the 249 extracts obtained have been investigated for in-vitro…”
Get full text

Early alterations of polyamine metabolism induced after acute administration of clenbuterol in mouse heart by Cubría, J.C., Ordóñez, C., Reguera, R.M., Tekwani, B.L., Balaña-Fouce, R., Ordóñez, D.

“…An acute treatment of mice with clenbuterol, a β-adrenergic agonist, produced a marked increase of polyamines levels in heart, particularly during the early…”
Get full text

Spectrophotometric determination of de novo hemozoin/β-hematin formation in an in vitro assay by Tripathi, Abhai K, Khan, Shabana I, Walker, Larry A, Tekwani, Babu L

“…Formation of hemozoin in the malaria parasite, due to its unique nature, is an attractive molecular target. Several laboratories have been trying to unravel…”
Get full text

Antimicrobial and antiparasitic (+)-trans-hexahydrodibenzopyrans and analogues from Machaerium multiflorum by Muhammad, I, Li, X.C, Jacob, M.R, Tekwani, B.L, Dunbar, D.C, Ferreira, D

“…Machaerium multiflorum yielded two additional new (+)-trans-hexahydrodibenzopyrans (HHDBP's), machaeriol C (1) and machaeriol D (2), and three new…”
Get full text

Prevalence of hypertension in psychiatric disorders by Vaish, A K, Kumar, H, Agrawal, C G, Chandra, M, Trivedi, J K, Ghatak, A, Tekwani, B L

“…To study the prevalence of hypertension in our cases with psychiatric disorders and to study if the prevalence is higher in the cases with psychiatric…”
Get more information

A Novel Active DNA Topoisomerase I in Leishmania donovani by Villa, Héctor, Otero Marcos, Ana R., Reguera, Rosa M., Balaña-Fouce, Rafael, Garcı́a-Estrada, Carlos, Pérez-Pertejo, Yolanda, Tekwani, Babu L., Myler, Peter J., Stuart, Kenneth D., Bjornsti, Mary-Ann, Ordóñez, David

“…A common feature shared by type I DNA topoisomerases is the presence of a “serine, lysine, X,X, tyrosine” motif as conventional enzyme active site. Preliminary…”
Get full text

Tetraazaacenaphthene, tetraazaphenalene and 1,3,4-thiadiazole derivatives as potential leishmanicides by Ram, V.J., Goel, A., Kandpal, M., Mittal, N., Goyal, N., Tekwani, B.L., Guru, P.Y., Rastogi, A.K.

“…Synthesis and leishmanicidal activity of 1,3-dithiolanes (2a,b), 1,3-dithiane (2c), tetraazaacenaphthene (4a-h) and tetraazaphenalene (4i,j),…”
Get full text

Biogenic amines, metabolites and monoamine oxidase in the filarial worm Setaria cervi by Agarwal, A, Shukla, O P, Ghatak, S, Tekwani, B L

“…Analysis of biogenic monoamines and their metabolites in Setaria cervi adults by reverse phase high performance liquid chromatography (HPLC) revealed dopamine…”
Get more information

S -ADENOSYLMETHIONINE SYNTHESIS IN LEISHMANIA INFANTUM PROMASTIGOTES by Reguera, R.M, Pérez-Pertejo, Y, Ordóñez, C, Cubrı́a, J.C, Tekwani, B.L, Balaña-Fouce, R, Ordóñez, D

“…Methionine adenosyltransferase (MAT), S -adenosylmethionine (AdoMet), and S -adenosylhomocysteine (AdoHcy), have been analysed at different time-points during…”
Get full text

Polyamine uptake by a Rodent Filariid, Acanthocheilonema viteae (nematoda: filarioidea) by Tekwani, B.L., Mishra, Manjari, Chatterjee, R.K.

“…Helminth parasites lack the capacity to synthesize polyamines de novo. With the view to characterise alternative pools for the replenishment of polyamines,…”
Get full text

Secretory cholinesterase of Ancylostoma ceylanicum: effect of tubulin binding agents and benzimidazole anthelmintics by Tekwani, B L

“…Ancylostoma ceylanicum, the human hookworm parasite, exhibited significant secretion of cholinesterase when maintained in vitro in RPMI-1640 medium. Secretion…”
Get more information

Kinetics of serotonin in platelets in essential hypertension by Nityanand, S, Tekwani, B L, Chandra, M, Shanker, K, Singh, B N

“…In a study of the kinetics of 5-hydroxytryptamine (5-HT) in platelets in 26 hypertensive subjects with a mean systolic and diastolic blood pressure of 153.9…”
Get more information

LC method for the determination of NPC1161, primaquine and their metabolites in various biological systems by AVULA, B, TRIPATHI, L. M, KHAN, S. I, TEKWANI, B. L, NANAYAKKARA, D, GUL, W, ELSOHLY, M. A, KHAN, I. A

Get full text