Search Results - "Tekmal, Rajeshwar"

Astrocyte-Derived Estrogen Regulates Reactive Astrogliosis and is Neuroprotective following Ischemic Brain Injury by Wang, Jing, Sareddy, Gangadhara R, Lu, Yujiao, Pratap, Uday P, Tang, Fulei, Greene, Karah M, Meyre, Pornjittra L, Tekmal, Rajeshwar R, Vadlamudi, Ratna K, Brann, Darrell W

“…Expression of the 17β-estradiol (E2) synthesis enzyme aromatase is highly upregulated in astrocytes following brain injury. However, the precise role of…”
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Brain-derived estrogen and neural function by Brann, Darrell W., Lu, Yujiao, Wang, Jing, Zhang, Quanguang, Thakkar, Roshni, Sareddy, Gangadhara R., Pratap, Uday P., Tekmal, Rajeshwar R., Vadlamudi, Ratna K.

“…Brain-derived estrogen (BDE2) produced by the enzyme aromatase has several important functions in the brain. Work using aromatase inhibitors, aromatase…”
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Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo by ANAND, Preetha, NAIR, Hareesh B, BOKYUNG SUNG, KUNNUMAKKARA, Ajaikumar B, YADAV, Vivek R, TEKMAL, Rajeshwar R, AGGARWAL, Bharat B

“…Curcumin, a yellow pigment present in the spice turmeric (Curcuma longa), has been linked with antioxidant, anti-inflammatory, antiproliferative, anticancer,…”
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Neuron-Derived Estrogen Is Critical for Astrocyte Activation and Neuroprotection of the Ischemic Brain by Lu, Yujiao, Sareddy, Gangadhara R, Wang, Jing, Zhang, Quanguang, Tang, Fu-Lei, Pratap, Uday P, Tekmal, Rajeshwar R, Vadlamudi, Ratna K, Brann, Darrell W

“…17β-Estradiol (E2) is produced from androgens via the action of the enzyme aromatase. E2 is known to be made in neurons in the brain, but the functions of…”
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Differential Effects of Estrogen Receptor β Isoforms on Glioblastoma Progression by Liu, Jinyou, Sareddy, Gangadhara R, Zhou, Mei, Viswanadhapalli, Suryavathi, Li, Xiaonan, Lai, Zhao, Tekmal, Rajeshwar R, Brenner, Andrew, Vadlamudi, Ratna K

“…The estrogen receptor β (ERβ) functions as a tumor suppressor in glioblastoma (GBM) cells. However, the significance of endogenous ERβ and the roles of its…”
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Lysine-specific histone demethylase 1A (KDM1A/LSD1) inhibition attenuates DNA double-strand break repair and augments the efficacy of temozolomide in glioblastoma by Alejo, Salvador, Palacios, Bridgitte E, Venkata, Prabhakar Pitta, He, Yi, Li, Wenjing, Johnson, Jessica D, Chen, Yihong, Jayamohan, Sridharan, Pratap, Uday P, Clarke, Kyra, Zou, Yi, Lv, Yingli, Weldon, Korri, Viswanadhapalli, Suryavathi, Lai, Zhao, Ye, Zhenqing, Chen, Yidong, Gilbert, Andrea R, Suzuki, Takayoshi, Tekmal, Rajeshwar R, Zhao, Weixing, Zheng, Siyuan, Vadlamudi, Ratna K, Brenner, Andrew J, Sareddy, Gangadhara R

“…Abstract Background Efficient DNA repair in response to standard chemo and radiation therapies often contributes to glioblastoma (GBM) therapy resistance…”
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Development and Evaluation of Talazoparib Nanoemulsion for Systemic Therapy of BRCA1 -mutant Cancer by Mehra, Neelesh Kumar, Tekmal, Rajeshwar R, Palakurthi, Srinath

“…This is a debut study report on talazoparib (BMN-673)-loaded nanoemulsion (TZNE) for parenteral administration. TZNE (0.05% drug, 151.4±0.7 nm droplet size,…”
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Therapeutic Use of Estrogen Receptor β Agonists in Prevention and Treatment of Endocrine Therapy Resistant Breast Cancers: Observations From Preclinical Models by Tekmal, Rajeshwar, Ramasamy, Kumaraguruparan, Samayoa, Cathy, Krishnegowda, Naveen

“…Breast cancer is one of the most common cancers in the world. The majority of breast cancers express estrogen receptor (ER)α, and endocrine therapy is the…”
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EC359: A First-in-Class Small-Molecule Inhibitor for Targeting Oncogenic LIFR Signaling in Triple-Negative Breast Cancer by Viswanadhapalli, Suryavathi, Luo, Yiliao, Sareddy, Gangadhara R, Santhamma, Bindu, Zhou, Mei, Li, Mengxing, Ma, Shihong, Sonavane, Rajni, Pratap, Uday P, Altwegg, Kristin A, Li, Xiaonan, Chang, Annabel, Chávez-Riveros, Alejandra, Dileep, Kalarickal V, Zhang, Kam Y J, Pan, Xinlei, Murali, Ramachandran, Bajda, Marek, Raj, Ganesh V, Brenner, Andrew J, Manthati, Vijaya, Rao, Manjeet K, Tekmal, Rajeshwar R, Nair, Hareesh B, Nickisch, Klaus J, Vadlamudi, Ratna K

“…Leukemia inhibitory factor receptor (LIFR) and its ligand LIF play a critical role in cancer progression, metastasis, stem cell maintenance, and therapy…”
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KDM1A inhibition is effective in reducing stemness and treating triple negative breast cancer by Zhou, Mei, Venkata, Prabhakar Pitta, Viswanadhapalli, Suryavathi, Palacios, Bridgitte, Alejo, Salvador, Chen, Yihong, He, Yi, Pratap, Uday P., Liu, Junhao, Zou, Yi, Lai, Zhao, Suzuki, Takayoshi, Brenner, Andrew J., Tekmal, Rajeshwar R., Vadlamudi, Ratna K., Sareddy, Gangadhara R.

“…Purpose Cancer stem cells (CSCs) are highly tumorigenic, spared by chemotherapy, sustain tumor growth, and are implicated in tumor recurrence after…”
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Neuron-Derived Estrogen-A Key Neuromodulator in Synaptic Function and Memory by Brann, Darrell W, Lu, Yujiao, Wang, Jing, Sareddy, Gangadhara R, Pratap, Uday P, Zhang, Quanguang, Tekmal, Rajeshwar R, Vadlamudi, Ratna K

“…In addition to being a steroid hormone, 17β-estradiol (E ) is also a neurosteroid produced in neurons in various regions of the brain of many species,…”
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SETDB1 interactions with PELP1 contributes to breast cancer endocrine therapy resistance by Liu, Zexuan, Liu, Junhao, Ebrahimi, Behnam, Pratap, Uday P, He, Yi, Altwegg, Kristin A, Tang, Weiwei, Li, Xiaonan, Lai, Zhao, Chen, Yidong, Shen, Liangfang, Sareddy, Gangadhara R, Viswanadhapalli, Suryavathi, Tekmal, Rajeshwar R, Rao, Manjeet K, Vadlamudi, Ratna K

“…Methyltransferase SETDB1 is highly expressed in breast cancer (BC), however, the mechanisms by which SETDB1 promotes BC progression to endocrine therapy…”
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Thymoquinone poly (lactide-co-glycolide) nanoparticles exhibit enhanced anti-proliferative, anti-inflammatory, and chemosensitization potential by RAVINDRAN, Jayaraj, NAIR, Hareesh B, BOKYUNG SUNG, PRASAD, Sahdeo, TEKMAL, Rajeshwar R, AGGARWAL, Bharat B

“…Thymoquinone (TQ), derived from the medicinal spice Nigella sativa (also called black cumin), has been shown to exhibit anti-inflammatory and anti-cancer…”
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KDM1A inhibition augments the efficacy of rapamycin for the treatment of endometrial cancer by Venkata, Prabhakar Pitta, Chen, Yihong, Alejo, Salvador, He, Yi, Palacios, Bridgitte E., Loeffel, Ilanna, Liu, Junhao, Pratap, Uday P., Gray, Gabrielle, Achuthan Pillai, Sureshkumar Mulampurath, Zou, Yi, Lai, Zhao, Suzuki, Takayoshi, Viswanadhapalli, Suryavathi, Palakurthi, Srinath, Tekmal, Rajeshwar R., Vadlamudi, Ratna K., Kost, Edward, Sareddy, Gangadhara R.

“…Endometrial cancer (EC) often exhibit aberrant activation of PI3K/Akt/mTOR signaling and targeted therapies using mTOR inhibitors showed limited success. The…”
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Therapeutic Targeting of Ovarian Cancer Stem Cells Using Estrogen Receptor Beta Agonist by He, Yi, Alejo, Salvador, Venkata, Prabhakar Pitta, Johnson, Jessica D, Loeffel, Ilanna, Pratap, Uday P, Zou, Yi, Lai, Zhao, Tekmal, Rajeshwar R, Kost, Edward R, Sareddy, Gangadhara R

“…Ovarian cancer (OCa) is the deadliest gynecologic cancer. Emerging studies suggest ovarian cancer stem cells (OCSCs) contribute to chemotherapy resistance and…”
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NSAID Use Reduces Breast Cancer Recurrence in Overweight and Obese Women: Role of Prostaglandin-Aromatase Interactions by BOWERS, Laura W, MAXIMO, Ilane X. F, BRENNER, Andrew J, BEERAM, Muralidhar, HURSTING, Stephen D, PRICE, Ramona S, TEKMAL, Rajeshwar R, JOLLY, Christopher A, DEGRAFFENRIED, Linda A

“…Obesity is associated with a worse breast cancer prognosis and elevated levels of inflammation, including greater cyclooxygenase-2 (COX-2) expression and…”
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Aromatase expression increases the survival and malignancy of estrogen receptor positive breast cancer cells by Mukhopadhyay, Keya De, Liu, Zhao, Bandyopadhyay, Abhik, Kirma, Nameer B, Tekmal, Rajeshwar R, Wang, Shui, Sun, Lu-Zhe

“…In postmenopausal women, local estrogen produced by adipose stromal cells in the breast is believed to support estrogen receptor alpha (ERα) positive breast…”
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Preclinical Development of Brain Permeable ERβ Agonist for the Treatment of Glioblastoma by Pratap, Uday P, Tidwell, Michael, Balinda, Henriette U, Clanton, Nicholas A, Yang, Xue, Viswanadhapalli, Suryavathi, Sareddy, Gangadhara R, Liang, Dong, Xie, Huan, Chen, Yidong, Lai, Zhao, Tekmal, Rajeshwar R, McHardy, Stanton F, Brenner, Andrew J, Vadlamudi, Ratna K

“…Glioblastoma (GBM) is the most prevalent and aggressive type of adult brain tumors with low 5-year overall survival rates. Epidemiologic data suggest that…”
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Pharmacological inhibition of KDM1A/LSD1 enhances estrogen receptor beta-mediated tumor suppression in ovarian cancer by Venkata, Prabhakar Pitta, Jayamohan, Sridharan, He, Yi, Alejo, Salvador, Johnson, Jessica D., Palacios, Bridgitte E., Pratap, Uday P., Chen, Yihong, Liu, Zexuan, Zou, Yi, Lai, Zhao, Suzuki, Takayoshi, Viswanadhapalli, Suryavathi, Weintraub, Susan T., Palakurthi, Srinath, Valente, Philip T., Tekmal, Rajeshwar R., Kost, Edward R., Vadlamudi, Ratna K., Sareddy, Gangadhara R.

“…Ovarian cancer (OCa) is the most lethal gynecologic cancer. Emerging data indicates that estrogen receptor beta (ERβ) functions as a tumor suppressor in OCa…”
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Development and Characterization of Inducible Astrocyte-Specific Aromatase Knockout Mice by Wang, Jing, Pratap, Uday P, Lu, Yujiao, Sareddy, Gangadhara R, Tekmal, Rajeshwar R, Vadlamudi, Ratna K, Brann, Darrell W

“…17β-estradiol (E2) is produced in the brain as a neurosteroid, in addition to being an endocrine signal in the periphery. The current animal models for…”
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